Advances in the treatment of neurodegenerative diseases (NDs) are nominal. Currently available therapies are merely symptomatic treatments that cannot prevent the development of the disease. Several herbs have been found very useful for managing neurological diseases. There are immense possibilities to discover a more successful line of ND treatment. Phytochemicals from medicinal plants may play a vital role in maintaining the chemical balance of the brain by affecting the capacity of receptors for the major inhibitory neurotransmitters. A few plants have already gained popularity for the potential treatment of NDs. This volume highlights the therapeutic role of medicinal plants and their scientific validation for improving neuronal health. It presents 15 chapters that cover the herbal treatment of NDs, including Parkinson’s disease and Alzheimer’s disease. The contents cover a range of pharmaceutical agents like sirtuins, berberine, rosmarinic acid and resveratrol. The book serves as a reference for pharmacology and herbal medicine scholars as well as healthcare workers interested in information about alternative and complementary therapies for neurological disorders.
Author(s): Surya Pratap Singh, Hareram Birla, Chetan Keswani
Publisher: Bentham Science Publishers
Year: 2023
Language: English
Pages: 323
City: Singapore
Cover
Title
Copyright
End User License Agreement
Contents
Foreword
Preface
List of Contributors
Parkinson's Disease: A Phytotherapeutic Prospective
Bhargab Deka1, Bedanta Bhattacharjee1, Naveen Shivavedi2, Gireesh Kumar Singh3, Hans Raj Bhat1, Surajit Kumar Ghosh1 and Anshul Shakya1,*
INTRODUCTION
NEUROPROTECTIVE ACTIVITY OF BIOACTIVE PHYTOCOMPOUNDS FROM MEDICINAL PLANTS
M. pruriens (Kauncha)
Plant Description
Phytoconstituents of M. pruriens
Neuroprotective Activity of M. pruriens in Parkinson’s Pathology
Curcuma longa (Turmeric)
Plant Description
Phytoconstituents of Turmeric
Neuroprotective Activity of Curcumin in Parkinson’s Pathology
Zingiber officinale (Ginger)
Plant Description
Phytoconstituents of Ginger
Neuroprotective Activity of Ginger in Parkinson’s Pathology
Bacopa monnieri (Brahmi)
Phytoconstituents of “Brahmi”
Neuroprotective Activity of “Brahmi” in Parkinson’s Pathology
Nardostachys jatamansi (Jatamansi)
Plant Description
Phytoconstituents of “Jatamansi”
Neuroprotective Activity of N. jatamansi in Parkinson’s Pathology
W. somnifera (Ashwagandha)
Plant Description
Phytoconstituents of Ashwagandha
Neuroprotective Activity of Ashwagandha in Parkinson’s Pathology
Silybum marianum (Silymarin)
Plant Description
Phytoconstituets of Silymarin
Neuroprotective Activity of Silymarin in Parkinson’s Pathology
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Delineating the Neuroinflammatory Crosstalk in Neurodegeneration and Probing the Near Future Therapeutics
Vinod Tiwari1,*, Ankit Uniyal1, Vineeta Tiwari1, Vaibhav Thakur1, Mousmi Rani1 and Akhilesh1
INTRODUCTION
NEUROINFLAMMATION: A FRIEND OR A FOE?
NEUROINFLAMMATION: A CRITICAL MEDIATOR FOR NEURODEGENERATIVE DISEASES
Parkinson’s Disease
Alzheimer’s Disease
Multiple Sclerosis
Huntington’s Disease
Amyotrophic Lateral Sclerosis
THERAPEUTIC PATHWAYS FOR THE NEAR FUTURE MANAGEMENT OF NEURODEGENERATION
Microglial Responsiveness Modulation: A Potential Tool for Neuroprotection
Peroxisome Proliferator-activated Receptor Gamma (PPARγ): A Potential Target against Neuroinflammation
P2X7 Purinergic Receptor-mediated Signalling and Neurodegeneration
NF-κB Signaling and Neuroinflammation
Toll-like Receptors: The Biological Switches for Neuroinflammation
NLRP3 Inflammasome and Caspase-1 Signalling in Neurodegeneration
Neuroinflammation-associated Oxidative Stress Multimodal Cascade
Neuroinflammation and Mitochondrial Dysfunction
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Modulations of SIRTUINs and Management of Brain Disorders
Sudhir Kumar Shekhar1,*, Sarfraj Ahmad Siddiqui2,* and Girish Rai3
INTRODUCTION
SIRTUINS STRUCTURE AND TYPES
SIRT1
SIRT2
SIRT3
SIRT4
SIRT5
SIRT6
SIRT7
SIRTUINS IN DIFFERENT BRAIN FUNCTIONS
SIRTUINS AND NEURODEGENERATIVE DISORDERS
Multiple Sclerosis (MS)
AD
PD
ALS
WD
Spinal Cord Injury (SCI)
Traumatic Brain Injury (TBI)
Stroke
MODULATION OF SIRTUINS
STACs
NBMs
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Beyond the Synthetic Drugs: Fungal Endophytes Derived Bioactive Compounds in the Management of Neurodegenerative Disorders
Ashish Verma1,#, Nilesh Rai1,#, Swapnil C. Kamble2, Pradeep Mishra3, Suvakanta Barik4, Rajiv Kumar1, Santosh Kumar Singh1, Prafull Salvi5 and Vibhav Gautam1,*
INTRODUCTION
FUNGAL ENDOPHYTE AS A SOURCE OF BIOACTIVE COMPOUND FOR MANAGING HEALTH DISORDERS
ROLE OF FUNGAL ENDOPHYTE-DERIVED BIOACTIVE COMPOUNDS IN TREATING NEURODEGENERATIVE DISEASES
Fungal Endophyte-derived Bioactive Compounds having Anti-neuroinflammatory Properties
Fungal Endophyte-derived Bioactive Compounds in Managing Neuro-hydrolases
Role of Fungal Endophyte-derived Bioactive Compounds in Managing Oxidative Stress Response
Role of Fungal Endophyte-derived Bioactive Compounds in the Management of Depression
CHALLENGES IN THE APPLICATION OF BIOACTIVE COMPOUNDS FOR THE MANAGEMENT OF NEURODEGENERATIVE DISORDERS
CONCLUSION AND FUTURE PERSPECTIVE
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Neuroprotective Role of Medicinal Plants from North Eastern Region of India
Bedanta Bhattacharjee1, Bhargab Deka1, Naveen Shivavedi2, Hans Raj Bhat1, Saurabh Kumar Sinha3, Surajit Kumar Ghosh1 and Anshul Shakya1,*
INTRODUCTION
NEUROPROTECTIVE HERBS
Allium sativum
Camella sinensis
Centella asiatica
Coriandrum sativum
Crocus sativus
Glycyrrhiza glabra
Morus alba
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Tinospora cordifolia in Neurodegeneration: A Strong Antioxidant and Anti-inflammatory Phytotherapeutic Drug Candidate
Anuradha Sharma1 and Gurcharan Kaur2,*
INTRODUCTION
BRAIN HEALTH AND NEUROLOGIC DISEASE BURDEN
IMMUNOMODULATORY ROLE OF T. CORDIFOLIA
ROLE OF T. CORDIFOLIA IN NEURODEGENERATION
T. cordifolia and Oxidative Stress
T. cordifolia and Neuroinflammation
Glutamate-induced Excitotoxicity
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Mucuna pruriens and Parkinson’s Disease: A Natural Approach to Treat PD
Mamta Tiwari1,* and Anurag Pandey2
INTRODUCTION
PATHOLOGY OF PD
SIGNS AND SYMPTOMS OF PD
AETIOLOGY OF PD
AYURVEDIC UNDERSTANDING OF PD
AETIOLOGY OF PD AS PER AYURVEDA (TABLE 2)
M. pruriens in Ayurveda
Properties of M. pruriens
M. pruriens as Source of L-DOPA
Neuroprotective Activity of M. pruriens
Hypoglycaemic Activity of M. pruriens
Anti-inflammatory Activity of M. pruriens
Anti-depressant Activity of M. pruriens
Antioxidant Activity of M. pruriens
DISCUSSION
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Bacopa monnieri and Neural Health: An Indian Herb
Prachi Pattnaik1, Chetan Panda2, Tarun Minocha3, Sanjeev Kumar Yadav3, Namrata Dwivedi4 and Sandeep Kumar Singh5,*
INTRODUCTION
WHAT ARE NEURODEGENERATIVE DISEASES?
PHYTODRUGS - THE POTENTIAL ALTERNATIVE
PERKS OF PHYTOMEDICINES OVER SYNTHETIC DRUGS
WHAT ARE NOOTROPICS?
ROLE OF PHYTOMEDICINES IN NEUROPROTECTION
BACOPA MONNIERI: A REAL FORTUNE FOR NEURAL HEALTH
Taxonomic Classification
Botany
Pharmaceutical Properties and Uses
Neuroprotective Aspect of Brahmi
Role of BM in Curing AD
Effect on Curing Cancer
Other Biological Activities of BM
CURRENT RESEARCH AND SCOPE
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Role of Curcumin in the Treatment of Neurological Disorders
Bhuwan Chandra Joshi1 and Yogita Dobhal2,*
INTRODUCTION
ROLE OF CURCUMIN IN VARIOUS NEUROLOGICAL DISORDERS
ALZHEIMER’S DISEASE (AD)
PARKINSON’S DISEASE (PD)
OTHER DISEASES
Amyotrophic Lateral Sclerosis (ALS)
Huntington’s Disease (HD)
Traumatic Brain Injury (TBI)
Glioma (GBM)
Cognitive Dysfunctions
Multiple Sclerosis (MS)
CURCUMIN IN CLINICAL TRIALS
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Pharmacology of Rosmarinic Acid against Psychological Disorders
Himanshu Verma1, Naveen Shivavedi1, Mukesh Kumar1 and Prasanta Kumar Nayak1,*
INTRODUCTION
SCIENTIFIC LITERATURE
PATHOPHYSIOLOGY OF PSYCHOLOGICAL DISORDERS
EPIDEMIOLOGY
CURRENT TREATMENT STRATEGIES
ROSMARINIC ACID (RA)
PHARMACOLOGY OF RA
PHYTOCHEMISTRY OF RA
THERAPEUTIC EFFICACY OF RA IN PSYCHOLOGICAL DISORDERS
CHALLENGES AND SAFETY CONSIDERATIONS
CONCLUSION AND FUTURE PERSPECTIVE
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Neuroprotective Effects of Berberine in Neurodegenerative and Neuropsychiatric Disorders
Rupinder Kaur Sodhi1 and Anurag Kuhad1,*
INTRODUCTION
SOURCE, BIOCHEMISTRY AND PHARMACOLOGY
BERBERINE IN NEURODEGENERATIVE DISORDERS
Alzheimer’s Disease (AD)
Parkinson’s Disease (PD)
Huntington’s Disease (HD)
Cerebral Ischemia
Traumatic Brain Injury (TBI)
BERBERINE IN NEUROPSYCHIATRIC DISORDERS
Depression
Schizophrenia
Anxiety
SAFETY OF BERBERINE
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Resveratrol: A Novel Drug for the Management of Neurodegenerative Disorders
Sapna Bala1, Anamika Misra2, Upinder Kaur3 and Sankha Shubhra Chakrabarti1,*
INTRODUCTION
CHEMISTRY
DIETARY SOURCES
METABOLISM
MECHANISM OF ACTION
Antioxidant Effect
AMPK (AMP-Activated Protein Kinase) Pathway
Sirtuins
OTHER MECHANISMS
RESVERATROL IN CELL CULTURE EXPERIMENTS
RESVERATROL IN ANIMAL MODELS
Reveratrol and Alzheimer’s Disease (AD)
Resveratrol and Parkinson’s Disease (PD)
Resveratrol in Other Neurodegenerative Disorders
CONCLUSION: RESVERATROL IN CLINICAL USE
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Protective Effect of Potent Protein-like Drug Isolated from Indian Medicinal Plants over Diabetic Neuropathy
Harsha Kashyap1,*, Hagera Dilnashin2 and Mukesh Kumar3
INTRODUCTION
DN
Imbalance of Oxidative Homeostasis
Alteration in Neurotransmitters
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Natural Herbs Polishing Memory: Neuroprotection against Alzheimer's Disease
Manisha Thakkur1,*, Hagera Dilnashin2 and Priyanka Kumari Keshri2
INTRODUCTION
EPIDEMIOLOGY
PATHOPHYSIOLOGY
Autosomal Dominant AD (ADAD)
Early-Onset AD (EOAD)
Late-Onset AD (LOAD)
MAJOR HYPOTHESES
β-amyloid Hypothesis
Hyperphosporelated Tau Hypothesis
Chronic Inflammation
Cholinergic Hypothesis
Metal Ion Hypothesis
CONCLUDING REMARKS AND SCIENTIFIC EVIDENCE FOR NEUROPROTECTIVE POTENTIAL OF INDIAN HERBS OR PHYTOCHEMICALS FOR ALZHEIMER’S DISEASE
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Neuroprotective Effect of Natural Products in Attenuation of Aging-associated Neurodegeneration
Abhai Kumar1 and Rameshwar Nath Chaurasia1,*
INTRODUCTION
NATURAL PRODUCTS AND NEUROPROTECTION
Honey
Propolis
Withania somnifera
Ginseng
Curcumin
Uncaria Rhynchophylla
Cyanobacteria
CHALLENGES AND FUTURE PERSPECTIVE
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Subject Index
Back Cover
