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Toxin-Antitoxin Systems in Pseudomonas aeruginosa

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Pseudomonas aeruginosa is known as a persistent bacterial pathogen. Antibiotics are currently the most common bacterial treatment for related infections but cases of microbial resistance are on the rise. Toxin-Antitoxin Systems in Pseudomonas aeruginosa describes one of the most important antimicrobial targets in the bacterium species. The contributors have compiled comprehensive information on the subject. The reference initially acquaints the reader with key topics about P. aeruginosa infection including virulence factors, pathogenicity, epidemiology, laboratory diagnosis and antibiotic resistance. This is followed by detailed chapters on toxin-antitoxin systems which explain their role in the bacterial pathogenesis with reference to P. aeruginosa. The comprehensive information on the subject makes this an ideal reference for newcomers to the field of bacteriology and target discovery. Students of medical microbiology and medical professionals who are interested in the finer details of P. aeruginosa pathogenicity will also be equipped with sufficient information to join the discussion on this topic with fellow researchers.

Author(s): Mina Mahmoudi, Sobhan Ghafourian, Behzad Badakhsh
Publisher: Bentham Science Publishers
Year: 2021

Language: English
Pages: 119
City: Singapore

Cover
Title
Copyright
End User License Agreement
Contents
Foreword
Preface
Acknowledgements
List of Contributors
An Overview of Pseudomonas aeruginosa
M. Mahmoudi1, S. Ghafourian1,* and B. Badakhsh2
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
History and Etymology
M. Mahmoudi1, S. Ghafourian1,*, N. Sadeghifard1 and B. Badakhsh2
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Virulence Factors of P. aeruginosa and Their Role in Pathogenicity
M. Mahmoudi1, S. Ghafourian1,*, A. Maleki2 and B. Badakhsh3
1. LIPOPOLYSACCHARIDE (LPS)
2. ADHESIONS
2.1. Type IV Pili (TFP)
2.2. Lectins
2.3. Alginate
2.4. Flagella
3. PIGMENTS
3.1. Pyoverdine
3.2. Pyocyanin
3.3. Pyorubin
3.4. Pyomelanin
3.5. Other Pigments
4. P. AERUGINOSA FORMS IN NATURE (PLANKTONIC AND BIOFILM)
5. TOXINS
5.1. Exotoxin A
5.2. Exotoxin S
5.3. Leukocidin (Cytotoxin)
5.4. Enterotoxin
6. ENZYMES
6.1. Phospholipase C (PLC)
6.2. Rhamnolipid
6.3. Proteases
6.3.1. LasB
6.3.2. LasA
6.3.3. Alkaline Protease
6.3.4. Protease IV
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Epidemiology
M. Mahmoudi1, S. Ghafourian1,*, N. Sadeghifard1 and B. Badaksh2
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Pathogenicity
M. Mahmoudi1, S. Ghafourian1,*, B. Badakhsh2, H. Kazemian1 and A. Maleki3
1. BACTEREMIA
2. BONE AND JOINT INFECTIONS
3. KERATITIS
4. PNEUMONIA
5. CHRONIC RESPIRATORY TRACT INFECTIONS
6. URINARY TRACT INFECTION (UTI)
7. SKIN AND SOFT TISSUES INFECTIONS
8. EAR INFECTIONS
9. ENDOCARDITIS
10. CENTRAL NERVOUS SYSTEM (CNS) INFECTIONS
11. ENTERIC INFECTION
12. MASTITIS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Laboratory Diagnosis
M. Mahmoudi1, S. Ghafourian1,*, H. Kazemian1 and B. Badaksh2
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Antibiotic Resistance and Treatment
M. Mahmoudi1, S. Ghafourian1,*, H. Kazemian1 and B. Badakhsh2
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Toxin-Antitoxin Systems
M. Mahmoudi1, S. Ghafourian1,* and A. Maleki2
1. CLASSIFICATION OF THE TA SYSTEMS
1.1. Type I TA System
1.2. Type II TA System
1.3. Type III TA System
1.4. Type IV TA System
1.5. Type V TA System
1.6. Type VI TA System
2. TA SYSTEM FUNCTIONS
2.1. Antibiotic Resistance
2.2. Biofilm Formation
2.3. Persister Cell Formation
2.4. Genomic Junk
2.5. Programmed Cell Death (PCD)
2.6. Post Segregational killing (PSK)
2.7. Plasmid Maintenance
2.8. Antiphage Activity
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Acquaintance with the Known Toxin-Antitoxin Systems in P. aeruginosa
M. Mahmoudi1, S. Ghafourian1,*, A. Maleki2 and B. Badakhsh3
1. HIGBA TA SYSTEM
2. HICAB TA SYSTEM
3. PARDE TA SYSTEM
4. RELBE TA SYSTEM
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Subject Index
Back Cover