Therapy of Viral Infections

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Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Author(s): Wibke E. Diederich, Holger Steuber (eds.)
Series: Topics in Medicinal Chemistry 15
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2015

Language: English
Pages: 226
Tags: Medicinal Chemistry

Front Matter....Pages i-vii
HIV-1 Integrase Drug Discovery Comes of Age....Pages 1-52
Phosphonated Nucleoside Analogues as Antiviral Agents....Pages 53-91
Recent Advances in Targeting Dengue and West Nile Virus Proteases Using Small Molecule Inhibitors....Pages 93-141
Strategies for the Development of Influenza Drugs: Basis for New Efficient Combination Therapies....Pages 143-181
Targeting Cellular Cofactors in HIV Therapy....Pages 183-222
Back Matter....Pages 223-226