This book describes the emergence and recent advances in the design and development of rhodium complexes as therapeutic agents. Different classes of anticancer rhodium complexes with particular emphasis on ligands containing nitrogen-oxygen donor atoms are presented. Anticancer rhodium complexes of N-heterocyclic carbenes are described, while half-sandwich, heterobimetallic, and multinuclear rhodium complexes are discussed. Therapeutic applications of rhodium complexes beyond cancer such as antibacterial agents or antiviral agents are also analyzed, among others. Their mechanism of action is overviewed in detail, and the authors thoroughly comment on the challenges and future outlooks of research in the development of rhodium metallodrugs. This title highlights the important research carried out in the development of therapeutic rhodium complexes and is of great interest to graduates and researchers working in the area of rhodium-based therapeutic drugs.
Author(s): Afzal Hussain, Mohamed F. Alajmi, Mushtaq Ahmad Lone, Waseem A. Wani
Series: SpringerBriefs in Molecular Science
Publisher: Springer
Year: 2023
Language: English
Pages: 87
City: Cham
Preface
Contents
About the Authors
Abbreviations
1 Introduction: Metal Complexes as Therapeutic Agents
References
2 Chemistry of Rhodium
References
3 Therapeutic Potential of Rhodium Complexes
3.1 Rhodium Complexes as Anticancer Agents
3.1.1 Anticancer Rhodium Complexes with Nitrogen–Oxygen Donor Ligands
3.1.2 Anticancer Rhodium Complexes with N-Heterocyclic Carbene Ligands
3.1.3 Anticancer Half-Sandwich Rhodium Complexes
3.1.4 Anticancer Heterobimetallic Rhodium Complexes
3.1.5 Anticancer Multinuclear Rhodium Complexes
3.1.6 Miscellaneous Anticancer Rhodium Complexes
3.2 Rhodium Complexes as Antibacterial Agents
3.3 Rhodium Complexes as Antifungal Agents
3.4 Rhodium Complexes as Antiviral Agents
3.5 Rhodium Complexes as Antiparasitic Agents
References
4 Mechanism of Therapeutic Action of Rhodium Complexes
4.1 Mechanism of Anticancer Action of Rhodium Complexes
4.1.1 Rhodium Complexes as DNA Interacting Agents
4.1.2 Rhodium Complexes as RNA Interacting Agents
4.1.3 Rhodium Complexes as Other Biomolecule Interacting Agents
4.2 Mechanism of Antibacterial, Antifungal, Antiviral and Antiparasitic Action of Rhodium Complexes
References
5 Challenges and Future Outlooks of Research
References
Index
