Therapeutic Platform of Bioactive Lipids: Focus on Cancer

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Bioactive lipid metabolism and signaling are now widely accepted as major players in cancer biology. This volume helps to fill the urgent need to explore and investigate the innovations, current shortcomings, and future challenges of cancer therapy through the bioactive lipids by presenting new research on the use of bioactive lipids as effective weapons against cancer. The volume introduces the subject and then goes on to cover the chemistry, formulation, and mechanism of bioactive lipids in cancer. The volume takes a close look at lipoxins, ceramides, resolvins, and sphingosine-1-phosphate and their roles in cancer treatment. It also addresses the formulations based on bioactive lipids for the treatment of cancer. A variety of mechanisms of bioactive lipids as novel therapies are also covered, including using computational techniques to identify bioactive lipid drug targets, targeting therapy via KRAS and PI3K signals, and others. The authors also discuss the role and effects of various substances and their effect on various cancers, including colorectal cancer, prostate cancer, breast cancer, and others. The application of lysophosphatidic acid, lipopolysaccharide, lipid-soluble bioactive substance from avocado, omega-3 polyunsaturated fatty acids-derived lipid metabolites, and more are covered as well. The volume offers academia, technologists, and scientists from different disciplines valuable information to gain knowledge of bioactive lipid metabolism and signaling as an anti-cancer weapon in their fight against cancer.

Author(s): Manjari Singh
Publisher: CRC Press/Apple Academic Press
Year: 2023

Language: English
Pages: 321
City: Palm Bay

Cover
Half Title
Title Page
Copyright Page
About the Editor
Table of Contents
Contributors
Abbreviations
Preface
Introduction
Part I: Chemistry of Bioactive Lipids
1. Ceramide: A Sphingolipidic Weapon Against Cancer
2. Lipoxins: Emerging Players in the Resolution of Cancer
3. Role of Resolvins as a Bioactive Lipid in the Treatment of Cancer
4. Sphingosine-1-Phosphate: An Important Target to Fight Against Cancer
Part II: Formulations Based on Bioactive Lipids
5. Bioactive Lipids for the Treatment of Cancer
6. Role of Exosomes as Natural Conveyors of Bioactive Lipids in Cancer
Part III: Mechanisms of Bioactive Lipids
7. Identification of Bioactive Lipid Drug Targets by Computational Techniques
8. Metabolism of Lipids in Malignant Solid Tumors Hypoxia and Drug Targets
9. Novel Targeting Therapy for Colorectal Cancer with Special Emphasis on KRAS and PI3K Pathway
10. Role of Lipid-Soluble Bioactive Substance from Avocado for Inhibition of Prostate and Other Cancers
11. Role of Lipopolysaccharides in the Pathogenesis of Cancer
12. Role of Lysophosphatidic Acid on Cancer
13. Role of Omega-3 Polyunsaturated Fatty Acids-Derived Lipid Metabolites on Cancer Hacks
Index