Neurons are excitable cells. They use ions and electrical signaling to talk to each to other and when they talk to each other, neurons control behavior. The Oxford Handbook of Neuronal Ion Channels is an accessible reference describing the nature and properties of ion channels in neurons. The book explains how ion channels open and close, how they can be selective for specific ions, and how they give rise to action potentials. Included are in-depth chapters discussing specific classes of ion channels: potassium channels, sodium channels, neurotransmitter-gated ion channels and other specialized channels. Throughout the handbook, important insight is provided on the contribution ion channels make to neuronal excitability and to synaptic transmission. The handbook goes further to discuss channelopathies, a group of human diseases such as epilepsy, pain and migraines that can be caused by ion channel dysfunction. For neuroscientists, biophysicists and neuropharmacologists, this
handbook is a valuable reference of ion channel biology and function.
Author(s): Arin Bhattacharjee
Series: Oxford Handbooks
Publisher: Oxford University Press
Year: 2023
Language: English
Pages: 783
City: New York
Cover
The Oxford Handbook of Neuronal Ion Channels
Copyright
Contents
Preface
Editor’s Bio
List of Contributors
Section 1 Basic Principles
1. Excitable Membrane Properties of Neurons
2. Ion Channel Permeation and Selectivity
3. Gating of Ion Channels
Section 2 Voltage-Gated Channels
4. The Voltage-Dependent K+ Channel Family
5. Potassium Channel Mutations in Epilepsy
6. The Voltage-Dependent Sodium Channel Family
7. Specialized Sodium Channels in Pain Transmission
8. Sodium Channelopathies of the Central Nervous System
Section 3 Ligand-Gated Channels
9. α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid and Kainate Receptors
10. N-Methyl-D-Aspartate Receptors
11. Nicotinic Acetylcholine Receptors
12. GABAA Receptor Physiology and Pharmacology
13. P2X Receptors
14. Large Conductance Potassium Channels in the Nervous System
15. Hyperpolarization-Activated Cyclic Nucleotide–Gated Channels
Section 4 Other Channels
16. Tandem Pore Domain Potassium Channels
17. TRPC Channels—Insight from the Drosophila Light Sensitive Channels
18. Acid-Sensing Ion Channels
19. TMEM16 Ca2+ Activated Cl– Channels and CLC Chloride Channels and Transporters
Index
