In this unique overview of the Hsp60 chaperonin, Peter Bross addresses molecular biologists, medical research scientists and individuals interested in molecular or general biology. First, Bross discusses the basics of the Hsp60 chaperonin in terms of its structure and the molecular mechanisms determining its function. Second, the author highlights the multiple roles of Hsp60 for cellular systems and regulatory pathways, especially in connection with neurodegenerative diseases caused by Hsp60 deficiency. Finally, the author highlights controversial observations suggesting additional, non-standard functions of Hsp60 in and outside mitochondria as well as possible gaps in our understanding of the chaperonin. This volume serves as a snapshot suitable for experienced researcher working in fields related to molecular chaperones yet still accessible to researchers entering the field.
Author(s): Peter Bross (auth.)
Series: SpringerBriefs in Molecular Science
Edition: 1
Publisher: Springer International Publishing
Year: 2015
Language: English
Pages: XI, 85
Tags: Protein Science; Bioorganic Chemistry; Molecular Medicine
Front Matter....Pages i-xi
Introduction....Pages 1-4
Historical Sketch of the Discovery and Recognition of the Function of Chaperonins....Pages 5-8
Molecular Structure of Chaperonins....Pages 9-12
Folding by Enclosure in the Chaperonin Cavity....Pages 13-15
Evolutionary Origins and Family Relations....Pages 17-22
Chaperoning Mechanisms: Folding Helpers, Folding Protectors, or Misfolding Blockers?....Pages 23-30
Sequence Variations in Proteins Affecting Chaperonin Dependence....Pages 31-39
Genetic Organization of Type I Chaperonin Genes....Pages 41-43
Regulation of Type I Chaperonin Gene Expression....Pages 45-49
Subcellular Localization....Pages 51-52
Posttranslational Modifications....Pages 53-53
Variations in Hsp60 and Hsp10 in Humans....Pages 55-56
Type I Chaperonins Are Essential for Cell Viability....Pages 57-58
Human Diseases Caused by Genetic Mutations in the Hsp60/Hsp10 System....Pages 59-63
Molecular Investigations of Disease Mechanisms....Pages 65-72
Outlook....Pages 73-74
Back Matter....Pages 75-85
