This new volume provides the most updated information about beta-lactams relating to both the pharmaceutical industry and synthetic chemistry. It provides the antibiotic activities as well as chemical reactivities of beta-lactams, which are important because they are commonly applied as antibiotics in the treatment of bacterial infections. The volume provides comprehensive coverage of most of the known beta-lactam antibiotics with both structural and biological information, antibiotic mechanisms, self-defense mechanisms of bacteria, nearly all known synthetic methods for the preparation of beta-lactams, and possible reactions in which beta-lactams can participate.
Key features
Provides the most comprehensive collection of beta-lactam antibiotics (up to 269 molecules) with chemical structures, CAS number, IUPAC names and associated biological activities attached
Offers a comprehensive and detailed collection of beta-lactamase databases
Explains the self-defense mechanisms of bacteria for surviving, including the formation of biofilm and conversion into L-form and secretion of beta-lactamase to deactivate the beta-lactam antibiotics
Provides a comprehensive survey on the synthetic methods to make beta-lactams
Gives all of the possible reactions involving beta-lactams as the starting materials
Surveys over 1000 research works and includes all available DOI information
The volume is a valuable resource on the antibiotic activities as well as chemical reactivities of beta-lactams for researchers and scientists, faculty, and advanced students, as well as for industry professionals working in medicinal and pharmaceutical chemistry, organic chemistry, organic synthesis, heterocycles, proteins and peptides.
Author(s): Zerong Wang
Publisher: CRC Press/Apple Academic Press
Year: 2023
Language: English
Pages: 467
City: Palm Bay
Cover
Half Title
Title Page
Copyright Page
About the Author
Table of Contents
Abbreviations
Acknowledgments
Preface
1. β-Lactams and Antibiotics
1.1 Brief Introduction
1.2 Penicillin Antibiotics
1.3 Cephalosporin Antibiotics
1.4 Carbapenem Antibiotics
1.5 Monobactam Antibiotics
1.6 Clavam Antibiotics
1.7 Miscellaneous β-Lactam Antibiotics
Keywords
References
2. Antimicrobial Activity of β-Lactams and Bacterial Resistance
2.1 Brief Introduction of Bacteria
2.2 Nomenclature and Classification of Bacteria
2.3 Antibacterial Mechanism
2.4 Resistance of Antibacterial Activity
2.5 Mechanisms for Antibiotics Resistance
2.6 β-Lactamases Databases
2.7 Other Biological Activities of β-Lactams
Keywords
References
3. Synthetic Methods of β-Lactams
3.1 Brief Introduction
3.2 Formation of β-Lactams Through Cycloadditions
3.3 Intramolecular Substitutive Cyclization
3.4 Enzymatic Synthesis of β-Lactams
3.5 Miscellaneous Methods
Keywords
References
4. Reactions of β-Lactams
4.1 Brief Introduction
4.2 Cleavage of the Amide Bond of β-Lactams
4.3 Preparation of Polyamides
4.4 Application in the Synthesis of Unnatural α-Amino Acid Derivatives and Relating Peptides
4.5 Nucleophilic Substitution on C3 or C4
4.6 Cleavage of C3-C4 Bond
4.7 Cleavage of N1-C4 Bond
4.8 Function at N1
Keywords
References
Index
