The book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases. In addition, several chapters raise awareness of centrosomes in areas that have not yet fully considered the centrosome as an organelle that impacts other organelle functions directly or indirectly. It further relates centrosome functions to other research areas such as aging and stem cell research.
Since its discovery almost 150 years ago the centrosome is increasingly being recognized as a most impactful organelle for its role, not only as primary microtubule organizing center (MTOC) but also as a major communication center for signal transduction pathways and as a center for proteolytic activities. Its significance for cell cycle regulation has been well studied and we now also know that centrosome dysfunctions are implicated in numerous diseases and disorders including cancer, cystic diseases of the kidney, liver fibrosis, cardiac defects, obesity and several other diseases and disorders.
This new volume reviews the latest advances in the field and provides valuable background information that is readily understandable for the newcomer and the experienced centrosome researcher alike. Due to the interdisciplinary of the subject, it is a valuable resource for researchers and clinicians working in biomedical research, cell biology, cancer biology, reproduction and developmental biology, neuroscience and stem cell research.
Author(s): Heide Schatten
Series: Advances in Anatomy, Embryology and Cell Biology, 235
Publisher: Springer
Year: 2022
Language: English
Pages: 114
City: Cham
Preface
Contents
Chapter 1: Cell and Molecular Biology of Centrosome Structure and Function
1.1 Introduction
1.2 Historical Perspectives
1.3 Centrosome Structure, Molecular Composition and Function
1.4 Centrosome Matrix and Centrosomal Proteins
1.4.1 Centrosomal Proteins
1.5 Centriole Structure and Cell Cycle-Specific Centriole Dynamics
1.5.1 Centriole Structure, Molecular Composition and Dynamics
1.6 In Vivo Imaging of Centrosomes
References
Chapter 2: The Centrosome Cycle within the Cell Cycle
2.1 Centrosome–Nuclear Interactions
2.2 Centrosome Maturation, Mitosis, and Cell Division
2.3 Chromosome (DNA)–Centrosome Synchronization Cycle: Coordination of DNA (Chromosome) and Centrosome Cycle
2.4 Centrosome–Golgi Relationships and Interconnected Functions
2.5 Primary Cilia
References
Chapter 3: Centrosome as Center for Proteolytic Activity and Dysfunctions Associated with Pathogenesis of Human Disease
3.1 Centrosomes as Center for Proteolytic Activity and Dysfunctions in Disease
3.2 Other Centrosome-Related Dysfunctions in Disease
3.3 Vesicular Transport Dysfunctions and Disease
3.4 Basal-Body Dysfunctions and Disease
References
Chapter 4: Centrosome Dysfunctions in Cancer
4.1 Viral Transformation and Aneuploidy
4.2 Oncogenes and Tumor Suppressor Genes
4.3 Centrosomes as Targets for Cancer Therapy
References
Chapter 5: Virus Exploitation (Hijacking) of Centrosomes
References
Chapter 6: Centrosomes in Reproduction
6.1 Introduction
6.2 The Importance of Choosing an Appropriate Animal Model
6.3 Centrosome Terminology Questions in Reproductive Cells
6.4 Centrosome Reduction During Gametogenesis
6.5 The Sperm Centriole Complex Before Fertilization
6.6 Centrosomes in Unfertilized Eggs and Oocytes
6.7 Centrosomes During Oocyte Maturation, Fertilization, and First Cell Division
6.7.1 Centrosomes During Oocyte Maturation
6.7.2 Centrosomes During Fertilization and Cell Division
6.8 Effects of Aging on Oocyte Centrosomes
References
Chapter 7: Transitions from Centrosomal to Non-centrosomal Microtubule Organization During Cellular Polarization
References
Chapter 8: External and Environmental Effects on Centrosomes
8.1 Effects of Ionizing Radiation on Centrosomes
8.2 Environmental and Genotoxic Stress on Centrosomes
8.2.1 Toxicants and Chemicals that Affect Centrosomes
References
Chapter 9: Centrosomes and Centrosome Equivalents in Other Systems
9.1 Stem Cells
9.2 Neuronal Cells
9.2.1 The Role of Centrosomes in Neuronal Development
9.2.2 Centrosome Dysfunctions in Neuronal Diseases/Disorders
9.2.3 Centrosomes in Neuronal Cells of the Aging Brain
9.3 T Cells (Cytotoxic T Lymphocytes; CTLs)
9.4 Centrosomes and Centrosome Equivalents in Other Systems and in Model Organisms
9.4.1 Parasites
9.4.2 Yeast
9.4.3 Dictyostelium
9.4.4 C. elegans
9.4.5 Drosophila
References
Chapter 10: Non-centrosomal Microtubule Organization in Plant Cells
10.1 The Mechanisms Underlying Mitotic Apparatus Formation and Orientation in Plants
10.2 The Role of γ-Tubulin in Plant Cells
References
