The book explores how kidney disease care is being changed by new technologies, from inception and diagnosis to dialysis and kidney transplant. Massive technological advances have affected health care in the past decade, and doctors are moving quickly to change the way we provide care for kidney diseases. We are rapidly shifting from hospital- and clinic-based systems to providing care at home, with technologies that help monitor care and intervene remotely. Some of the technologies covered include genetic testing for diagnostic and therapeutic purposes, metabolism/ezposome assessment, AI-driven tool for drug dosing, and apps available to patients. This book aims to educate providers on the many new scientific and technological interventions that can help monitor and mitigate kidney disease.
Author(s): Subodh J. Saggi, Moro O. Salifu
Publisher: Springer
Year: 2022
Language: English
Pages: 199
City: Cham
Preface
Contents
Chapter 1: Genetic Testing for the Management of Kidney Disease
Rationale for the Use of Genetic Tests in Diagnosing Kidney Disease
Establishing Genetic Diagnoses Impacts Clinical Care
Genetic Testing Available in the Clinic
Genomic Approaches and Return of Results
Ethical, Legal, Social Considerations and Return of Results
Summary
References
Chapter 2: Application of Artificial Intelligence and Machine Learning in Kidney Disease
Artificial Intelligence and Machine Learning
Data and ESKD
AI Applications in Kidney Disease
Conclusion
References
Chapter 3: The Role of The Metabolism/Exposome in Chronic Kidney Disease: Discovery for Precision Nutrition
Need of Novel Biomarkers for Chronic Kidney Disease
Metabotype and Metabolomics Analysis
Targeted and Untargeted Metabolomics Analysis
Genetic Variations in CKD and Relationship to Proteins and Metabolites
Exposome and CKD
Recent Findings in CKD Research
Systems Biology Approach (Phenotypic, Metabolomic, and Genetic Data) for Biomarker Discovery in CKD
Arginine and Taurine as Biomarkers of Diabetic Nephropathy (DN)
Influence of Microbiome in CKD
Precision Nutrition in Treatment and Prevention of CKD
Concluding Remarks
References
Chapter 4: Microbiome Derived Metabolites in CKD and ESRD
Introduction
Microbiome in Health and Disease
Microbiome in Kidney Disease
Microbiome Derived Metabolites
Inflammation
Immune Dysregulation
Hypertension
Progression of Kidney Disease
Cardiovascular Disease
Obesity and Insulin Resistance
Microbiome Therapeutics
Conclusion
References
Chapter 5: Psychological Factors Associated with Adjustment to Kidney Disease and Engagement in Novel Technologies
Stress of Kidney Disease
Symptom Burden
Treatment Demands of CKD/ESRD
Etiology of Depression and Anxiety in CKD and ESRD
Epidemiology of Depression and Anxiety in CKD and ESRD
Technology Acceptance
Technology Acceptance in Healthcare Settings
Technology Acceptance in CKD
Improving Technology Acceptance
Conclusion
References
Chapter 6: Current Dietary Advances in Enhancing Adherence in ESRD Patients
General Dietary Guidelines for End Stage Renal Disease Patients
Where Can End Stage Renal Disease Patients Find Pertinent Nutrition Information
Planning Kidney Friendly Meals
How to Help Patients Achieve Recommended Nutrition Goals
What Exists and What Needs to Improve to Help ESRD Patients Meet Their Nutrition Goals
References
Chapter 7: Current Strategies to Enhance Opportunities for Patients with End Stage Kidney Disease to Receive a Kidney Transplant
References
Chapter 8: Blood Pressure Measurement in Chronic Kidney Disease and End Stage Renal Disease
Introduction
BP Management (Guidelines and Methods)
Blood Pressure Load
Blood Pressure Variability
Arterial Stiffness
HTN Old-School Vs. New-School Thinking
Summary
References
Chapter 9: Assessing Volume Overload in Patients on Dialysis
Introduction
Physiology
Devices to Assess Volume
Bioimpedance
Thoracic Electrical Bioimpedance
Blood Volume Monitoring
Ultrasound
CardioMEMS
Remote Dielectric Sensing (ReDS)
Indicor (Investigational Use)
Conclusion
References
Chapter 10: Technologies to Monitor Dialysis Dose, Vascular Access Function and Improve Toxin Removal
Introduction
Technologies for Online Monitoring of Dialysis Dose
EID-Na+ Based Methods
UV Spectrophotometry-based Method
Optimizing Dialysis Dose
Optimizing the Removal of Middle Molecules and Protein-Bound Toxins
High-Flux Dialyzers
On-Line Hemodiafiltration
Medium Molecular Cut-off Membranes
Removal of Protein-Bound Toxins
References
Chapter 11: Technologies Transforming AV Fistula Creation: “Endo-AVF or Percutaneous-AVF”
History of Hemodialysis Access
The Endo-AVF Concept
Two Technologies
Clinical Data
Access Planning in the Age of Endo-AVF
Screening for Anatomic Feasibility
Conclusions
References
Chapter 12: Delaying the Onset and Progression of CKD in People with Diabetes: Technology and Effectiveness in Achieving Glucose Control
Introduction
CKD in Diabetes and Mortality
Role of Glycemic Control in Preventing the Progression of CKD
Technology in the Prevention of Diabetic Kidney Disease
Technology in Established ESRD and Diabetes
References
Chapter 13: Strategies and Technologies to Advance Kidney Health from Kidney Health Initiative
Strategies and Technologies to Advance Kidney Health from Kidney Health Initiative
Patient Innovator Challenge Winners
References
Chapter 14: Current Noninvasive Technologies in Interventions to Control Hyperparathyroid Bone Diseases of CKD and ESRD
Introduction
Patients and Methods
Results
Discussion
References
Chapter 15: Sudden Cardiac Death in End Stage Kidney Disease: Technologies for Determining Causes and Predicting Risk
Introduction
Cardiac Arrythmias and Sudden Cardiac Death in ESKD
Ventricular Arrythmia
Atrial Fibrillation
Bradycardia
Electrolyte Abnormalities and Sudden Cardic Death in ESKD
Potassium and SCD
Calcium and SCD
Bicarbonate and SCD
Approaches to Defining the Underlying Cardiac Arrythmias in SCD AND ESKD
Implantable Loop Recorders
ECG Patch Monitors
Implantable Cardioverter Defibrillators
Approaches to Predicting the Risk of Sudden Death
Autonomic Tone and Sudden Cardiac Death
Electrophysiology and Sudden Cardiac Death
Positron Emission Tomography and Sudden Cardiac Death
Implantable Cardioverter Defibrillators and Sudden Cardiac Death
Electrophysiology and Point of Care and Sudden Cardiac Death
Artificial Intelligence and Sudden Cardiac Death
Conclusion
References
Chapter 16: Current and Future Technologies to Enhance Acceptance of Peritoneal Dialysis
Introduction
The Current Use of Cyclers in PD
History and Innovation in PD Cycler Technology
Selected Examples of Troubleshooting Using Sharesource
Innovation in Biocompatible PD Dialysate Solutions
Generation of Individualized PD Fluid at Home
Future Developments
References
Chapter 17: Project ECHO: Building Workforce Capacity to Improve Care for Patients with Kidney Disease
Introduction
Project ECHO: Moving Knowledge, Not People
Becoming a Project ECHO Nephrology Hub
Discussion
References
Chapter 18: Use of Artificial Intelligence/Machine Learning for Individualization of Drug Dosing in Dialysis Patients
References
Chapter 19: Pathogenesis of Coronary Artery Disease in Chronic Kidney Disease: Strategies to Identify and Target Specific Populations
Coronary Artery Disease in People with Chronic Kidney Disease
Dyslipidemia in ESRD
Pathogenesis of CAD in CKD: New Insights
Protein Carbamylation
Macrophage Function in ESRD
Autophagy
Strategies to Identify and Target Specific Populations
Future Directions
References
Index
