Stem Cells : Biology and Application, 1e

Cover
Half Title
Title Page
Copyright Page
Contents
Preface
Acknowledgments
Part I: An Introduction to Stem Cells
1. The essential principles of stem cell science
1.1 The Defining Properties of a Stem Cell
1.2 The Necessity for Stem Cells
1.3 The Control of Stem Cell Function Is Complex and Varied
1.4 The Therapeutic and Economic Potential of Stem Cells
1.5 Summary
Further reading
2. Stem cell identification, isolation, and characterization
2.1 Identification of Stem Cells
2.2 Isolation of Stem Cells
2.3 Characterization of Stem Cells
2.4 Summary
Further reading
Part II: Stem Cell Potency and Control
3. Embryonic stem cells, cloning, and pluripotency
3.1 Pluripotent Cells Derived from Vertebrate Embryos
3.2 Pluripotent Cells Derived by Cloning
3.3 Pluripotent Cells from Non-Mammalian Species
3.4 Summary
Further reading
4. Controlling stem cells: Receipt and interpretation of external cues
4.1 Signal Transduction Pathways Utilized by Stem Cells
4.2 How the Stem Cell Machinery Responds to Signal Inputs
4.3 Summary
Further reading
5. Cell plasticity, reprogramming, and induced pluripotent stem cells
5.1 Reversibility of the Differentiated State of Adult Cells
5.2 Reprogramming Adult Cells to Become Pluripotent Stem Cells
5.3 Stem Cell Plasticity and Lineage Reprogramming Revisited
5.4 Summary
Further reading
6. The stem cell niche
6.1 Stem Cells Have a Defined Environment
6.2 Architecture of Stem Cell Niches: Similarities across the Animal and Plant Kingdoms
6.3 How Does the Niche Contact and Communicate with Stem Cells?
6.4 Changes in the Stem Cell Niche Can Contribute to Tissue Failure during Aging
6.5 The Role of Stem Cell Niches in Malignancy
6.6 Targeting Stem Cell Niches as a Therapeutic Option
6.7 Summary
Further reading
Part III: Stem Cells across the Animal and Plant Kingdoms
7. Regeneration in animals: The evolution of stem cells
7.1 The Nature of Regeneration
7.2 Animals That Regenerate Using Stem Cells
7.3 Regeneration of Animal Structures That Do Not Require Stem Cells
7.4 Regeneration in Vertebrates Is Not Restricted to Limbs
7.5 Summary
Further reading
8. Plant stem cells
8.1 The Nature of Stem Cells in Plants
8.2 The Regulation of Plant Stem Cells
8.3 Regeneration in Plants and Its Link to Stem Cells
8.4 Similarities and Differences between Plant and Animal Stem Cells
8.5 Summary
Further reading
Part IV: Stem Cells in Specialized Adult Animal Tissues
9. Hematopoietic stem cells
9.1 Evolutionary Diversification of Blood Cells and Their Stem Cells
9.2 Mammalian Hematopoietic Stem Cells
9.3 Cell Heterogeneity and the Niche Have Effects on Clinically Relevant Aspects of Hematopoietic Stem Cell Behavior
9.4 Stem Cells Supporting Blood Cells in Invertebrates
9.5 Summary
Further reading
10. Musculo-skeletal and dental stem cells in mammals
10.1 The Fundamental Components of the Mammalian Skeleton, Dentition, and Musculature
10.2 Mesenchymal Stem Cells
10.3 Dental Stem Cells
10.4 Skeletal Muscle Stem Cells
10.5 Summary
Further reading
11. Stem cells in endoderm-derived organs
11.1 Gastrointestinal Tract Lining Stem Cells
11.2 Gastrointestinal Tract Associated Organ Stem Cells
11.3 Stem Cells in the Respiratory Tract
11.4 Summary
Further reading
12. Stem cells underpinning the generation of germ cells
12.1 Stem Cells throughout the Reproductive Cycle
12.2 Mechanisms That Regulate Germ Stem Cells
12.3 Summary
Further reading
13. Stem cells in the cardiovascular system
13.1 Circulatory Systems in Complex Animals
13.2 Stem Cells in the Vasculature
13.3 Stem Cells in the Heart
13.4 Summary
Further reading
14. Stem cells in the nervous and sensory systems
14.1 Nervous Systems in Animals
14.2 Stem Cells in the Central Nervous System
14.3 Stem Cells Supporting the Sensory Organs in the Peripheral Nervous System
14.4 Summary
Further reading
15. Stem cells in the skin, its appendages, and other epithelial tissues
15.1 Epithelia: The Frontier Tissues of the Body
15.2 Stem Cells in the Skin
15.3 The corneal epithelium
15.4 Stem Cells in the Epithelia of the Gastrointestinal Tract
15.5 Stem Cells in Mammary Glands
15.6 Summary
Further reading
16. Atypical stem cells that enable and modulate immune system function
16.1 Effector Cells of the Immune System
16.2 Hematopoietic Stem Cell-Independent Myeloid Cells in the Innate Immune Response
16.3 Memory Cells of the Adaptive Immune Response have Stem Cell Properties
16.4 Stem Cells in the Primary and Secondary Lymphoid Organs
16.5 The Immune Modulatory Function of Mesenchymal Stem Cells
16.6 Summary
Further reading
Part V: Biomedical and Economic Applications of Stem Cells
17. Stem cells in biomedicine: Disease modeling and tissue repair
17.1 The Unmet Need in Medicine That Can Benefit from the Application of Stem Cells
17.2 Modeling Disease Using Stem Cell Derived Cells
17.3 Making Use of an Individual.’.s Resident Cells for Repair and Regeneration
17.4 Using Externally Sourced Stem Cells in Regenerative Medicine
17.5 Tissue Engineering
17.6 Progress, Failures, and Prospects in Stem Cell-Based Regenerative Medicine
17.7 Summary
Further reading
18. Stem cells in biomedicine: Stem cells in aging and cancer
18.1 The role of stem cells in tissue aging
18.2 The Role of Stem Cells in Cancer
18.3 Summary
Further reading
19. Stem cell applications in domesticated and wild animals and in horticulture
19.1 Animal Health, Agricultural Productivity, and Biomedical Advancement Involving Animals
19.2 Species Conservation
19.3 Horticultural Development
19.4 Summary
Further reading
20. Stem cells and society: A philosophical, ethical, and economical view
20.1 Philosophical and Moral Perspectives
20.2 Exploiting Stem Cells
20.3 The Economic Perspective
20.4 Summary
Further reading
Glossary
Index