Под редакцией R.B. Merrifield. — 2nd edition. — Pierce chemical company, 1984. — 176 p. — ISBN 0-935940-03-0Contents
The chemistry of solid phase peptide synthesis
Introduction: the solid phase reaction principle
The polymer support
The peptide-resin link
Protection of alpha-amino groups
Blocking of side-chain functional groups
The deprotection step
The neutralization step
The coupling reaction
Monitoring SPPS
Cleavage of peptides from resin
Side reactions in SPPS
Purification of peptides
Problems in handling and use of peptides
References for chapter 1
Laboratory techniques in SPPS
Starting materials
Solid phase synthesis of peptides
Purification of peptides
Analytical techniques
References for chapter 2
Apparatus for solid phase peptide synthesis
Manual solid phase synthesis
Automatic solid phase synthesis
Maintenance of glassware
References for chapter 3
Appendices
