Recent Developments in Neurodegeneration discusses the diverse functions of nitric oxide regarding redox regulation, the cellular energy pool, modifications in genetic material, neurogenesis, the effects on protein degradation mechanisms and functional consociation with glial cells. The authors consider the latest evidence that demonstrates that Alzheimer’s disease-associated proteins and their genes play a key role in the post-ischemic development of neurodegeneration with dementia. The main processes associated with secondary tissue damage following traumatic injury to the nervous system are reviewed. In closing, a comprehensive investigation of the combination of tremor and olfactory perception characteristics among patients with Parkinson’s disease and essential tremor is presented.
Author(s): Roger M. Howe
Series: Neurology – Laboratory and Clinical Research Developments
Publisher: Nova Science Publishers
Year: 2020
Language: English
Pages: 159
City: New York
Contents
Preface
Chapter 1
Nitric Oxide and Cellular Homeostasis: Updates in Neurodegenerative Mechanisms
Abstract
Abbreviations
1. Introduction
2. NO Mediated Neurodegenerative Mechanisms
2.1. Nitric Oxide and Oxidative Stress
2.2. Nitric Oxide and Mitochondrial Dysfunction
2.3. Nitric Oxide and Protein Modification
2.4. Nitric Oxide and Endoplasmic Reticulum Stress
2.5. Nitric Oxide and Protein Degradation Mechanism
2.6. Nitric Oxide and DNA Damage
2.7. NO and Apoptosis
2.8. NO and Autophagy
2.9. NO and Glial Cells
3. Evidences for Role of NO in CNS-Neurodegenerative Diseases
3.1. Evidences for Role of NO in AD Pathology
3.2. Evidences for Role of NO in PD Pathology
3.3. Evidences for Role of NO in HD Pathology
3.4. Evidences for Role of NO in ALS Pathology
Future Perspective and Conclusion
References
Chapter 2
Participation of Brain Ischemia in the Development of the Genotype and Phenotype of Alzheimer’s Disease
Abstract
Introduction
Dysregulation of Amyloid Associated Genes in Post-Ischemic Brain
Amyloid in Post-Ischemic Brain
Dysregulation of the Tau Protein Gene in Post-Ischemic Brain
Tau Protein in Post-Ischemic Brain
Neuropathology in Post-Ischemic Brain
Dementia Following Brain Ischemia
Conclusion
Acknowledgments
References
Chapter 3
Inflammatory Response, Excitotoxicity and Oxidative Stress Following Traumatic Brain Injury
Abstract
Introduction
Excitotoxicity Following Brain Injury
Inflammation Following Brain Injury
Oxidative Stress Following Brain Injury
Conclusion
Acknowledgments
References
Biographical Sketches
Chapter 4
All Around the Nose of Parkinsonism and Essential Tremor
Index
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