Poison pills; The untold story of the Vioxx drug scandal

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To the millions of Americans who suffer from chronic pain and arthritis, Vioxx seemed like a miracle. One of the most widely promoted and prescribed pain medications in the world -- used by more than twenty million people -- it was endorsed by the medical establishment and celebrities such as Olympic champion figure skater Dorothy Hamill. With annual sales of $2.5 billion, Vioxx became a pharmaceutical bonanza before being abruptly taken off the market in September 2004, after it was revealed that it led to an increased risk of heart-related disease and death. Drawing on internal documents, video footage, court testimony, and exclusive interviews, as well as three decades of experience inside the medical industry, Tom Nesi tells the dramatic story of what the drug’s manufacturer, Merck, knew and when. It is a compelling narrative of business and medical science run amok, with a cast of characters ranging from those at the highest levels of the multibillion-dollar pharmaceutical industry to research scientists, marketers, and drug company sales reps. Here also are accounts from physicians, lawyers, financial analysts, and patients and their families whose lives have been forever altered by Vioxx. Set against a fascinating history of the origins of the modern pharmaceutical industry, POISON PILLS is a shocking tale that involves the breakdown of the United States medical system, the failures of the Food and Drug Administration, and enormous profits made by a large pharmaceutical corporation at the potential cost of thousands of lives.

Author(s): Thomas Nesi
Year: 2008

Language: English
Commentary: no index
Pages: 280
Tags: Medicine; Drug safety; corruption; BigPharma; Vioxx Scandal; Merck; Celebrex; settlement; FDA; regulation; agency approval; Conflicts of interest; Drug marketing; Clinical trials; adverse events; patient deaths; doctors disrepute; statistics; side effects; efficacy; iatrogenic prescription mortality; patient deaths; corporate psychopathy; sociopathic corporatism; misconduct; serial fraud; revolving door; fake science; fake medicine; disinformation; misinformation;

CONTENTS
Copyright © 2008 by Thomas Nesi.
Dramatis Personae
Prelude
Part I
1 Shooting Stars
2 Super Aspirin and Poison Pills
3 Cox in Paradise
4 The Pharmaceutical Miracle
Part II
5 The Evolution of Ethics in Modern Medicine: How a Dye Changed History
6 The Advertising Miracle
7 Super Aspirin Is Born
8 Discovery
9 The Epidemic Blossoms
Part III
10 The War Begins
11 Bursting the Bubble
12 The Vioxx Mystique and Hypnotized Water: The Development of Modern Drug Testing
13 Is Super Aspirin Safe and Effective?
14 The Cool Blonde
15 Celebrex Meets the FDA
16 Payback Time
Part IV
17 Vioxx Gastrointestinal Outcomes Research
18 Spinning the Results
19 Medical “Interpretation”
20 Getting Out the Vioxx Message: The Cyber Obstacleizer
Part V
21 Science in Reverse
22 Losing Their Minds
23 Path of Destruction
24 The Drug Warriors
25 FDA vs. FDA
26 After the Party
Coda
Follow-Up
Author’s Note
Acknowledgments
Notes
Select Bibliography
About the Author