This book describes the updates that have been made in the field of Plasma Biosciences and Medicine over the past few years. This book provides detailed introduction and includes recent research information on plasma sources and their biological and medical applications. The opening chapters discuss plasmas physics and chemistry and plasma-activated liquids. The later part of the book discusses emerging application in medicine and biology. This book also provides valuable clinical insights into the treatment of ulcerations, wounds, cancer, dentistry, or the use of cold plasma in health and hygiene. Main target audience of this book are researchers, graduate and undergraduate students, government agencies, academicians’, engineers, biologists, medical doctor, biochemists, and industries.
Author(s): Eun Ha Choi
Series: Topics in Applied Physics, 148
Publisher: Springer
Year: 2023
Language: English
Pages: 323
City: Singapore
Contents
Contributors
1 Introduction to Nonthermal Atmospheric Pressure Plasma: Physical and Chemical Basis
1.1 Introduction to Plasma Bioscience and Medicine
1.1.1 Plasma Medicine is a New Division of Medical Science and Technology
1.1.2 Controllability and Safety of Plasma
1.1.3 Plasma Application to Biology and Medicine from the Very First Steps Till Today
1.1.4 Plasma as a Helpful Tool for Medicine, Electric Discharges in Plasma Medicine
1.1.5 Plasma Chemistry: A Basic Foundation
1.1.6 Applied Plasma Medicine
1.2 Plasma for Cancer Therapy
1.2.1 Background
1.2.2 In Vivo Applications
1.2.3 Clinical Studies
1.3 Non-thermal Atmospheric Pressure Plasma Diagnostics
1.3.1 Optical Emission Spectroscopy (OES) for Plasma
1.3.2 Measurement of the Electron Density by Using Optical Interferometer
1.3.3 Measurement of the Plasma Radicals by Using Ultraviolet Absorption Spectroscopy
1.3.4 Plasma Parameter Characteristics for Industry and Biomedical Plasma Products
References
2 Cancer Treatment and Immunomodulation by Nonthermal Plasma Technology
2.1 Introduction
2.2 Plasma-Induced Anticancer Effects and Signaling Mechanism
2.2.1 Plasma-Based Activation of Immune Cells
2.3 Plasma-Based Immunogenic Effect
2.4 Conclusion and Future Prospective
References
3 Cold Plasma in Dentistry
3.1 Introduction on Dentistry
3.1.1 Oral Tissues
3.1.2 Oral Environment
3.1.3 Common Dental Disease
3.2 Application of Cold Plasma on Dental Materials
3.2.1 Application of Cold Plasma on Dental Implant Surfaces
3.2.2 Application of Cold Plasma on Adherend for Improved Bonding
3.2.3 Application of Cold Plasma on Dental Materials for Other Purposes
3.3 Application of Cold Plasma on Dental Cells or Tissues
3.4 Others
References
4 Nonthermal Plasma-Based Virus Inactivation and Sterilization
4.1 Introduction of Animal Viruses
4.1.1 Definition of Virus
4.1.2 Human Viral Epidemics of Recent Forty years
4.1.3 Structure and Function of Virus
4.1.4 Classification and Nomenclature of Animal Viruses
4.2 Overview of Emerging Human Coronaviruses
4.2.1 Common Cold Causing Coronaviruses in Human
4.2.2 SARS Causing Viruses
4.3 Plasma-Based Virus Inactivation Strategies, and Mechanisms
4.4 Conclusion and Future Prospective
References
5 Cold Plasma Based Wound Healing Application
5.1 Background/Introduction
5.2 Wound Healing
5.2.1 Acute Wounds
5.2.2 Chronic Wounds
5.3 Cold Atmospheric Pressure Plasma and Chronic Infected Wounds
5.3.1 Anti-Microbial Effects
5.3.2 Cold Plasma in Cell Culture
5.4 Animal Studies Applying Cold Plasma
5.5 Clinical Application of Cold Plasma for Wound Healing
5.6 Cellular Redox Balance Modulated by Cold Plasma
5.7 Summary
References
6 Agriculture and Food Processing Applications
6.1 Background
6.2 Application of Non-thermal Atmospheric Pressure Plasma to Prevent Seed Borne Infections
6.2.1 General Treatment of Seeds
6.2.2 Effect of Cold Plasma Treatment on Fungi
6.2.3 Effect of Plasma Treatment on Bacteria
6.2.4 Effect of Plasma Treatment on Viruses
6.3 Application of Non-thermal Atmospheric Pressure Plasma to Seed Germination and Plant Growth
6.3.1 Plasma Effects on Seed Surface Morphology
6.3.2 Chemical Modification of the Seed Surface
6.3.3 Alterations of Seed Surface Hydrophobicity
6.3.4 Alterations of Seed Water Absorbance
6.3.5 Plasma Effects on Seed Germination and Plant Growth Parameters
6.3.6 Plasma Effects on Seed and Plant Physiology
6.4 Application of Non-thermal Plasma to Food Sanitation
6.4.1 Vegetables and Fruits
6.4.2 Meats, Meat Products, and Fishes
6.4.3 Packaged Foods
6.4.4 Processed Foods
6.5 Application of Non-thermal Plasma to Food Quality and Functional Property
6.6 Conclusion and Future Perspectives
References
7 Plasma Devices for Cosmetic and Aesthetic Treatment
7.1 Plasma Devices
7.2 Opportunities for Plasma Devices in Cosmetics/Aesthetics Applications
7.3 Trends of Plasma Technology in Cosmetics and Marketing
7.4 Optimization of Plasma Dose for Wound Healing and Cancer Treatment
7.5 NBP Anti-Cancer Effect During in Vivo and in Vitro Application
7.6 Human Skin Anatomy
7.7 Methods of Enhancing Skin Permeability
7.8 Skin and Its Microenvironment
7.9 Chitosan Biocompatible Material as Skin Rejuvenation
7.10 Skin Treatment by Using Nonthermal Plasma
7.11 Plasma Activated Water Play Important Role in Skin Rejuvenation
7.12 Plasma Skin Regeneration Treatment in the Dermo-Cosmetic Application
7.12.1 Epithelialized Skin Diseases that Are Highly Contaminated with Germs
7.12.2 Wounded Epidermis and Germ-Contaminated Skin Diseases Treatment
7.12.3 The Effect of Plasma on the Skin Surface
References
8 Clinical Studies on Cold Gas Plasma Applications: The Autonomous Patient and Getting Informed Consent for Treatment and Clinical Studies
8.1 Background
8.2 Template
8.2.1 General Aspects of Plasma Medicine
8.2.2 Selection of Patients
8.2.3 Choice of Plasma Devices
8.2.4 Handling of Complications
8.2.5 Frequently Asked Questions
References
9 Safety Aspects and Standardization
9.1 Background
9.2 Confirmation of Plasma ME for Wound Treatment
9.3 The Role of RONS in Cancer Therapy Protection Against Excessive Reactive Species
9.4 Plasma Current
9.5 Plasma Temperature
References
10 Biological Effects of Pulsed High-Power Microwaves
10.1 Introduction
10.1.1 Origin of Pulsed HPMW
10.2 Applications of HPMW
10.2.1 Military Based Applications
10.2.2 Industry Based Applications
10.2.3 Medical Applications
10.2.4 Communication Satellite and Astronomy-Based Applications
10.2.5 Spectroscopy
10.3 Important High Power Microwave Sources
10.3.1 Backward Wave Oscillator (BWO)
10.3.2 Gyrotrons
10.3.3 Magnetrons
10.3.4 Vircator
10.3.5 Basic Concept of Vircator
10.4 Introduction of Vircator Based Pulsed Power Generator, “Chundoong”
10.5 Formation of Virtual Cathode and HPMW Generation
10.6 Electromagnetic (EM) Field Interaction with Biological Systems
10.6.1 Mechanism for Action of EM Fields in Biology
10.7 The Biological Effects of EM Field of HPMW
10.7.1 Effect of EM Field on Skin
10.7.2 Effects of EM Field on the Reproductive system
10.7.3 Effect of EM Field on Brain
10.7.4 Biological Effect of High-Power Short Pulses of EM Field
10.7.5 Effect of Long-Time Exposure of EM Field
10.7.6 The Electric Field of HPMW Generated by Chundoong
10.7.7 Generation of Reactive Species by HPMW Exposure
10.7.8 Bacterial Inactivation by EM Field of Microwave Radiation
10.8 Summary
References
Index
