Physical chemistry: principles and applications in biological sciences

Written specifically for the life-science student, the Fifth Edition of the bestselling Physical Chemistry: Principles and Applications in Biological Sciences with MasteringChemistry® covers core aspects of biophysical chemistry, while showing how biochemists and biophysicists use principles of physical chemistry to solve real problems in biological systems. The addition of MasteringChemistry to the program puts a host of effective online homework, tutorial, and assessment tools at students’ and instructors’ fingertips. Features • A streamlined treatment covers the core aspects of biophysical chemistry (thermodynamics and kinetics as well as quantum mechanics, spectroscopy, and X-ray diffraction), which are of great importance to students of biology and biochemistry. Essentially all applications of the concepts are of interest to life-science students; nearly all the problems apply to life-science examples. • Clear, explicit writing helps students, especially those with weaker math skills, cement their conceptual understanding of physical chemistry • An appropriate level of mathematics uses elementary calculus to derive equations and carefully defines the scope of mathematics needed to solve problems. • Emphasis on methods such as modern fluorescence, calorimetry and single molecule techniques introduces students to techniques that are important in biochemistry and molecular biology • Theory of molecular structure and interactions begins with the origins of quantum mechanics, and builds up to intermolecular and intramolecular forces and the use of semi-empirical methods to calculate molecular conformation, giving students a better understanding of the concepts and methods used to calculate and predict macromolecular structures • Emphasis on nuclear magnetic resonance and fluorescence spectroscopy provides an in-depth look at the two main methods used to study proteins and nucleic acids in solution. • Updated coverage of molecular structures and X-ray diffraction (Ch. 15) offers a detailed discussion of how a structure is obtained from a measured diffraction pattern. X-ray diffraction available to non-specialists to determine structures of proteins and nucleic acids. New to this edition • NEW sequence of chapters: Content has been expanded, updated, and reorganized to aid instructors’ coverage and discussion of important topics within physical chemistry. Theoretical concepts now appear up front sooner and with more breadth for statistical methods and includes a new chapter devoted to Electrochemistry (Chapter 7). Comprehension of the fundamental principles is key to a successful life-science career. • NEW visual program with over 200 pieces of new and revised figures helps students visualize and understand the concepts discussed within each chapter. • Updated to current IUPAC conventions for relevancy. • A NEW appendix (Math Appendix A) in the Fifth Edition provides an accessible, concise, and self-contained review of the mathematics that students are expected to know in order to succeed in this course. Emphasizing the practical applications of a core set of mathematical methods, this appendix also includes an introduction to vector spaces in quantum mechanics. • Coverage of molecular spectroscopy has been expanded into two more focused chapters, with more grounding in underlying principles that students will need to master in order to pursue a life science career. The chapter on optical spectroscopy (chapter 13) gives expanded presentations of fluorescence and IR spectroscopies of proteins, while the magnetic resonance chapter (chapter 14) now includes multi-dimensional and diffusion NMR and their applications to biomolecules. • Specific examples of statistical weights in ligand binding and molecular conformations help students understand hormone and drug binding to receptors, and the folding of proteins and nucleic acids. • Updated applications engage students by introducing them to the latest research applications of physical chemistry important in biochemistry and molecular biology. • Coverage of quantum chemistry has been expanded into two chapters (11 and 12) with elaboration and updates on the contemporary work in this field and applications in biophysics