This book is a concise guide that provides an easy to follow template for other physicians to develop similar stem cell based treatments within their specialty. It identifies and summarizes the current world-wide orthopedic stem cell trials.
Organized into three sections, Orthopedic Stem Cell Surgery presents clinical studies that examine the procedures for setting up and implementing stem cell surgery within the specialty of orthopedics. Chapters maintain an accessible narrative while also addressing complex studies related to orthopedic stem cell surgery.
A sister text to the recently published, Retinal and Optic Nerve Stem Cell Surgery, and Neurologic Stem Cell Surgery this expertly written book examines critical Institutional Review Board (IRB) approved studies.
Author(s): Jeffrey N. Weiss
Publisher: Springer
Year: 2021
Language: English
Pages: 281
City: Cham
Preface
Contents
Part I: Rotator Cuff Repair
1: Mesenchymal Stem Cell Augmentation in Patients Undergoing Arthroscopic Rotator Cuff Repair
Summary
Intervention
Outcome Measures
Primary Outcome
Secondary Outcome
Functional Outcome
Patient-Centered Outcome
Eligibility
Inclusion Criteria
Exclusion Criteria
Further Reading
2: Bone Marrow-Derived Stem Cells for the Treatment of Rotator Cuff Tears
Summary
Intervention
Outcome Measures
Primary Outcome
Secondary Outcome
Inclusion Criteria
Exclusion Criteria
3: Regenexx™ SD Versus Exercise Therapy for Rotator Cuff Tears
Summary
Intervention
Outcome Measures
Primary Outcome
Secondary Outcome
Inclusion Criteria
Exclusion Criteria
Further Reading
4: Safety and Efficacy of Adult Adipose-Derived Stem Cell Injection into Partial-Thickness Rotator Cuff Tears
Summary
Intervention
Outcome Measures
Primary Outcome
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
5: Autologous Adult Adipose-Derived Regenerative Cell Injection into Chronic Partial-Thickness Rotator Cuff Tears
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Other Outcome Measures
Inclusion Criteria
Exclusion Criteria
6: Clinical Study on Mesenchymal Stem Cells Used in the Reconstruction Surgery of the Supraspinatus Muscle Lesions
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
Further Reading
7: Efficacy of Microfragmented Lipoaspirate Tissue in Arthroscopic Rotator Cuff Repair
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
8: Mesenchymal Stem Cells in Rotator Cuff Repair
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
9: Treatment of Tendon Disease Using Autologous Adipose-Derived Mesenchymal Stem Cells
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
Further Reading
10: Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Criteria
Inclusion Criteria
Exclusion Criteria
Part II: Knee Osteoarthritis
11: Impact of Mesenchymal Stem Cells in Knee Osteoarthritis
Summary
Intervention
Outcome Measures
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Knee Osteoarthritis Subjects
Focal Chondral Defect Subjects
Inclusion Criteria
Exclusion Criteria
Further Reading
12: Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES)
Summary
Intervention
Outcome
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
13: Early Regenerative Intervention for Post-Traumatic Osteoarthritis (ERIPTO)
Summary
Intervention
Outcome Measures
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
Further Reading
14: Prospective Evaluation of PRP and BMC Treatment to Accelerate Healing After ACL Reconstruction
Summary
Intervention
Outcome
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
15: Open-Ended Trocar Vs. Fenestrated Blunt Trocar in Bone Marrow Aspirate for Osteoarthritis
Summary
Intervention
Outcome
Primary Outcome Measures
Secondary Outcome Measures
Other Outcome Measures
Eligibility Criteria
Inclusion Criteria
Exclusion Criteria
16: The Effect of Microfragmented Adipose Tissue (MFAT) on Knee Osteoarthritis
Summary
Intervention
Outcome
Primary Outcome Measures
Secondary Outcome Measures
Other Outcome Measures
Inclusion Criteria
Exclusion Criteria
17: A Disease-Based Treatment Study for Diagnosed Osteoarthritis Utilizing Adipose-Derived Regenerative Cells
Summary
Intervention
Outcome
Primary Outcome Measures
Secondary Outcome Measures
Other Outcome Measures
Inclusion
All Cohorts
Inclusion Criteria—All Cohorts
Ankle Cohort
Hip Cohort
Knee Cohort
Shoulder Cohort
Wrist Cohort
Exclusion Criteria—All Cohorts
Ankle Cohort
Hip Cohort
Knee Cohort
Shoulder Cohort
Wrist Cohort
18: Stem Cell and Growth Factor Injury and Arthritis Clinical Research Study
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
19: Adipose-derived Mesenchymal Stem Cells in Osteoarthritis
Summary
Intervention
Outcome
Primary Outcome Measures
Scoring and Interpretation
Secondary Outcome Measures
Methods
Inclusion Criteria
Exclusion Criteria
20: Wharton’s Jelly-derived Mesenchymal Stem Cells in Osteoarthritis
Summary
Intervention
Outcome
Primary Outcome Measures
Secondary Outcome Measures
Methods
Inclusion Criteria
Exclusion Criteria
21: A Study Evaluating the Efficacy of a Single Injection Autologous Adipose-Derived Mesenchymal Stromal Cells in Patients with Knee Osteoarthritis (ADIPOA-2)
Summary
Intervention
Outcome
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
22: Synovium Brushing to Augmented Microfracture for Improved Cartilage Repair (AURA)
Summary
Detailed Description
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
23: Subchondral and Intra-articular Application of Bone Marrow Concentrate for Knee Unicompartmental OA (Marrow Mule)
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
Further Reading
24: Treatment of Early Knee Osteoarthritis with Autologous Adipose-Derived Mesenchymal Stem Cells
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
Further Reading
25: Clinical Study of Pulp Mesenchymal Stem Cells in the Treatment of Primary Mild to Moderate Knee Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
26: Very Small Embryonic-Like Stem Cells for Knee Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
27: Allogenic Adipose Tissue-Derived Mesenchymal Progenitor Cells for the Treatment of Knee Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Other Outcome Measures
Inclusion Criteria
Exclusion Criteria
28: Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells (GXCPC1) for Knee Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
29: Treatment of Knee Osteoarthritis with Autologous Adipose-Derived Mesenchymal Stem Cells
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
30: Clinical Study of Umbilical Cord Mesenchymal Stem Cells (UC-MSC) for Treatment of Knee Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
31: Mesenchymal Stem Cell Transplantation for Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
32: Effectiveness of Autologous Adipose-Derived Stem Cells in the Treatment of Knee Cartilage Injury
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
Further Reading
33: Adipose-Derived Stem Cells (ADSCs) for Knee Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
34: Allogeneic Bone Marrow MSC Therapy for Knee Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
35: Evaluate Safety and Explore Efficacy of SMUP-IA-01 in Patients with Knee Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
36: Clinical Trial to Compare ReJoinTM to Sodium Hyaluronate Injection for Knee Osteoarthritis Cartilage Defects
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
Further Reading
37: Follow-Up Study for Participants of JointStem Clinical Trial
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
38: A Phase 3 Study to Evaluate the Efficacy and Safety of JointStem in the Treatment of Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
39: Follow-Up Safety and Efficacy Evaluation on Subjects Who Completed Phase I Clinical Trial
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
40: Clinical Study of Intra-articular Injection of Catholic MASTER Cell (Bone Marrow-Derived Mesenchymal Stem Cell) in Knee Osteoarthritis (MSC-OA)
Summary
Intervention
Primary Outcome Measures
Inclusion Criteria
Exclusion Criteria
41: Follow-Up Study for Participants of JointStem Phase 3 Clinical Trial
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Eligibility Criteria
Inclusion Criteria
Exclusion Criteria
42: Investigator-Initiated Trial to Evaluate the Efficacy and Safety of Intra-articular Injection of ADMSC Compared to Negative Control After High Tibial Osteotomy in the Osteoarthritis Patients
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
43: Autologous Microfragmented Adipose Tissue Injection for Knee Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
44: The Safety/Efficacy of Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-OA) Therapy for Patients with Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
45: Wharton’s Jelly Originated Mesenchymal Stem Cell in Gonarthrosis (WHAMKO)
Summary
Intervention
Primary Outcome Measures
Inclusion Criteria
Exclusion Criteria
46: Use of Adipose Tissue-Derived Mesenchymal Stem Cells for Knee Osteoarthrosis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
47: Use of Wharton’s Jelly-Derived Mesenchymal Stem Cells for Knee Osteoarthrosis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
48: Effects of α MAT Versus Steroid Injection in Knee Osteoarthritis (STα MAT-Knee Study)
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
49: Implantation of Allogenic Mesenchymal Stem Cell from Umbilical Cord Blood for Osteoarthritis Management
Summary
Intervention
Primary Outcome Measures
Inclusion Criteria
Exclusion Criteria
Further Reading
50: Comparative Effectiveness of Arthroscopy and Non-arthroscopy Using Mesenchymal Stem Cell Therapy (MSCs) and Conditioned Medium for Osteoarthritis (OA)
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
51: The Evaluation of Safety and Effectiveness of Intra-articular Administration of Autologous Stromal Vascular Fraction of Adipose Tissue Cells for Treatment of Knee Joint Arthrosis
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
52: Efficacy of Bone Marrow-Derived and Placenta-Derived Multipotent Mesenchymal Stem/Stromal Cells for Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
53: Bone Marrow Versus Adipose Autologous Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis
Summary
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Inclusion Criteria
Exclusion Criteria
Further Reading
Part III: Labral Repair
54: BMAC Use with Labral Repair
Summary
Introduction
Intervention
Primary Outcome Measures
Secondary Outcome Measures
Biospecimen Retention: Samples with DNA
Study Population
Inclusion Criteria and Rationale
Exclusion Criteria and Rationale
Further Reading
Index
