Natural Products in Vector-Borne Disease Management explores the potential application of natural products in vector control and disease management. The chapters discuss the global impact of specific vector-borne diseases, gaps in management, and natural products in specific stages of development - discovery, optimization, validation, and preclinical/clinical development. Toxic effects and mechanisms of action are also discussed. This book also explores how therapeutic plant derivatives can be used to combat the vectors of infection and how natural products can be used to manage and treat vector-borne diseases like malaria, leishmaniasis, dengue, and trypanosomiasis.
With the inclusion of case studies on field and clinical applications and the contributions from experts in the field, Natural Products in Vector-Borne Disease Management is an essential resource to researchers, academics, and clinicians in parasitology, virology, microbiology, biotechnology, pharmacology, and pharmacognosy working in the field of vector-borne diseases.
Author(s): Nagendra Singh Chauhan, Durgesh Nandini Chauhan
Publisher: Academic Press
Year: 2023
Language: English
Pages: 603
City: London
Front Cover
Natural Products in Vector-Borne Disease Management
Copyright
Dedication
Contents
Contributors
Foreword
Preface
Chapter 1 Potentials of natural products in vector-borne diseases management: Current and future perspectives
Introduction
Ancient
Modern
Vector control strategies
Biochemical strategies
Biological control agents
Repellents
Insect traps
Vector-borne disease and its management
Malaria
Filariasis
Dengue
Zika virus
Chikungunya
Yellow fever virus
Miscellaneous
Natural products
Neem oil
Citronella oil
Lavender oil
Peppermint oil
Allium sativum
Citrullus colocynthis L.
Ocimum basilicum L.
Dysoxylum malabaricum
Khaya senegalensis
Ficus benghalensis
Lansium domesticum
Moschosma polystachyum
Ocimum sanctum
Magnolia salicifolia
Triphyophyllum peltatum
Microcos paniculata
S. curtisii
Piper longum
Pisonia alba
Terminalia chebula
Mechanism of action of phytochemicals in target insect body
Epidemiology
WHO guidelines for vector-borne diseases
Future prospects
Current trends, opportunities, and knowledge gaps in vector-borne diseases management with botanical products
Conclusion
References
Chapter 2 Evidence-based review of medicinal plants for the management of onchocerciasis
Introduction
Epidemiology
Life cycle of Onchocerca volvulus
Clinical manifestation and diagnosis of onchocerciasis
Current treatment and challenges
Models for assessing the antionchocerca activity of plant extracts and isolated compounds
Methods used for pinpointing herbal materials and natural products with antionchocerca from published literature
Plants used for treating onchocerciasis
Annonaceae
Apocynaceae
Araceae
Combretaceae
Cucurbitaceae
Cyperaceae
Euphorbiaceae
Fabaceae
Flacourtiaceae
Lamiaceae
Meliaceae
Piperaceae
Rubiaceae
Sapotaceae
Verbenaceae
Conclusion
References
Chapter 3 Plant-derived compounds as potential treatment for arboviruses
Introduction
Alphaviruses
Chikv
Mayv
Flaviviruses
Dengue virus
Zika virus
West Nile virus
Japanese encephalitis virus
Plant-derived antivirals against arboviruses infections
References
Chapter 4 Natural products in the management of onchocerciasis
Introduction
Conventional drugs for onchocerciasis and their resistance
Ivermectin
Moxidectin
Ivermectin-albendazole
Ivermectin-diethylcarbamazine-albendazole
Amocarzine
Secondary plant metabolites with antionchocerca activity
Pure natural products with antionchocerca activity
Safety and toxicity profiles of the natural products agents
Mode of action of natural plant products
Inhibit polymerization of structural protein
Disturb membrane fluidity
Conclusion
References
Chapter 5 Combating the vectors and management of vector-borne diseases with essential oil nanoemulsions
Introduction
What is vector?
Types of vectors
Types of vector-borne disease
Mosquito-borne diseases
Fly-borne diseases
Tick-borne diseases
Flea-borne diseases
Other vector-borne diseases
Prevention of vectors and management of vector-borne diseases
Essential oils
Chemical composition of EOs
Applications of EOs
Nanoemulsion
Properties of NEms
Components of NEms
Methods for NEms preparation
Essential oil nanoemulsion
EONEms on vector-borne diseases
Role as insecticide
Role as repellent
Role as antiparasite
Role against acari
Role against mosquitoes
Larvicidal effect
Adulticidal effect
Concluding remarks
References
Web-Servers
Chapter 6 Natural product for management of babesiosis
Introduction
Clinical information on babesiosis
Role of natural products in management of babesiosis
Treatment
Prevention
Conclusion
Conflict of interest
References
Further reading
Chapter 7 Antimicrobial peptides, nanocarrier systems, and databases: Therapeutic platform against leishmaniasis
Introduction
Global leishmaniasis surveillance: WHO report
Currently available leishmaniasis drugs
Antimicrobial peptides: An overview
AMPs as antileishmanial agents
Nanotechnology-based treatment of leishmaniasis
Phytocompounds-based nanoformulation as antileishmanial agents
Drugs-loaded nanocarrier systems as antileishmanial agents
Databases toward developing new antileishmanial drugs
Leish-ExP ( Leishmania- Exclusive Protein) database
LeishBase database
Conclusions and future perspective
References
Chapter 8 Marine organisms as natural drug leads in combating vector-borne diseases
Introduction
Shedding the light on leishmaniasis
Seaweeds (macro-algae) with promising antileishmanial activity
Marine invertebrates with a promising antileishmanial activity
Phylum Porifera
Phylum Cnidaria
Phylum Chordata
Phylum Mollusca
Phylum Arthropoda
Phylum Echinodermata
Phylum Ectoprocta
Shedding the light on malaria
Marine organisms with promising antimalarial activity
Shedding the light on trypanosomiasis
Marine organisms with promising antitrypanosomal activity
References
Chapter 9 Plant and marine-derived antimalarial agents
Introduction
Experiments to assess antimalarial activities of various agents
Mechanisms of action (MOA) proposed for isolated antimalarial compounds from natural products
Overview of numerous plant and marine-derived antimalarial agents
Important plants and marine species with antiplasmodial activities
Alkaloids
Terpenes and terpenoids
Phenolic compounds
Other phytochemical compounds
Natural products with malaria transmission blocking activity
Concluding remarks
References
Chapter 10 Natural products in the management of schistosomiasis
Introduction
Schistosoma life cycle
Pathophysiology
Current treatment
Chemotherapy
Antischistosomal agents of synthetic origin
Praziquantel (PZQ)
Metrifonate
Oxamniquine
Formulation of vaccine
Natural products for management of schistosomiasis
Alkaloids and alkamides
Essential oils
Lignans and neolignans
Diarylheptanoids
Flavonoids
Saponins
Terpenoids
Artemisinin derivatives
Other miscellaneous compounds
Conclusion
References
Further reading
Chapter 11 An update on antileishmanial agents from natural resources
Introduction
Life cycle
Natural products in the management of Leishmaniasis
Conclusion
References
Chapter 12 Plants with antidengue properties: A systematic review
Introduction
Epidemiology
Pathophysiology of dengue fever
Symptoms of dengue
Transmission of dengue
Treatment and management of dengue
Plant species used to treat dengue
Acacia catechu
Allium sativum
Andrographis paniculata
Anisuan
Azadirachta indica
Boerhavia diffusa
Carapichea ipecacuanha
Castanospermum australe
Curcuma longa
Echinacea
Glycyrrhiza glabra
Kaempferia parviflora
Mimosa scabrella
Momordica charantia
Myrtopsis corymbosa
Papaya leaves
Pippli
Uncaria tomentosa
Zostera marina
Conclusion
References
Chapter 13 Natural products in Japanese encephalitis
Introduction
Plant extracts in vector control
Isolated phytochemicals in vector control
Antiviral activity of plant-derived agents and their mechanism of action
Conclusion
References
Chapter 14 Algae natural products for potential vector-borne disease management
Introduction
Vector-borne diseases characterization and context
Algae importance
Algae-derived agents against VBD
Polysaccharides
Pigments
Proteins (lectins and griffithsin)
Polyphenols
Other compounds—Secondary metabolites
Cyanobacteria
Macroalgae
Alga-based extracts and fractions
Alga-based vaccine strategies
Alga-based larvicidal strategy
Challenges and perspectives
References
Chapter 15 Natural products in the management of trypanosomiasis
Introduction
About trypanosomiasis
Epidemiology
Current therapeutic approaches and associated challenges
Natural products in the management of trypanosomiasis
Plants against trypanosomiasis (in vitro studies)
Aloaceae
Annonaceae
Apocynaceae
Asteraceae
Bignoniaceae
Boraginaceae
Canellaceae
Didymellaceae
Fabaceae
Gramineae
Hymenocardiaceae
Lamiaceae
Lauraceae
Leguminosae
Loganiaceae
Meliaceae
Menispermaceae
Myrtaceae
Rubiaceae
Rutaceae
Siparunaceae
Verbenaceae
Zingiberaceae
Marine sources
Phytochemical against trypanosomiasis
Plants against trypanosomiasis (in vivo studies)
Patents
Mode of actions
Conclusion
Conflict of interest
Sources of funding
Acknowledgment
References
Further reading
Chapter 16 Concept of vector-borne diseases in Ayurveda: A review
Introduction
Agantuka roga
Modes of transmission of diseases
Janapadodhwamsa
Krimi
What are vectors?
Conclusion
References
Chapter 17 Medically important vector-borne disease control through seaweeds against the chikungunya
Vector-borne disease
Mosquito-borne diseases
Chikungunya
Vector-borne disease control
Vector control
Natural products
Seaweed
Acknowledgments
References
Chapter 18 Nanobiomaterials as novel modules in the delivery of artemisinin and its derivatives for effective management o ...
Introduction
ARTM derivatives
ARTM and derivatives: Pharmacokinetics
Delivery systems loaded with ARTM and its derivatives
Polymer-drug conjugates (poly-drug-con)
Micelles
Liposomes
Nanocapsules
Niosomes
Ethosomes
Solid lipid nanoparticle
Nanoparticles
Lipid-based nanoparticles
Polymer-based NPs and inorganic-based NPs
Polymer-based NPs
Inorganic-based NPs
Conclusions
Acknowledgments
Conflict of interest
References
Chapter 19 Scientific and ethnopharmacological evidence of Carica papaya for the effective management of vector-borne disease
Introduction
Ethnomedical considerations
Pharmacognostical character
Origin and distribution
Macroscopic character
Roots
Stem
Leaves
Flower
Fruits
Seeds
Microscopic characters
Phytochemistry
Fruits
Seeds
Leaves
Juice
Roots
Medicinal use of Carica papaya Linn. in vector-borne diseases
Antidengue effects
Antimalarial activity
Chikungunya
Agent for vector control in Filariasis
Antiviral action against Zika virus (family: Flaviviridae)
Japanese encephalitis
Chagas disease (American trypanosomiasis)
Conclusion
References
Further reading
Chapter 20 Nanoemulsion as a promising carrier of plant-derived repellents for mosquito-borne malaria control: Nanotechnol ...
Introduction
Mosquito repellents for malaria prevention
Plant-derived mosquito repellents
Controlled release nanotechnology
Nanoemulsion as carrier of essential oils (EOs)
Preparation of nanoemulsions
Characterization of nanoemulsions
Stability of the nanoemulsion
Application of nanoemulsion in malaria control
Conclusions and recommendations
Acknowledgments
Conflicts of interest
References
Chapter 21 Insect repellent plants: A recent update
Introduction
Alkaloids
Terpenoids
Saponins
Essential oils
Conclusion
Acknowledgment
References
Chapter 22 Natural products employed in the management of malaria
Introduction
First-generation natural products against malaria
Exploration of antiplasmodial drugs: Discovery of diverse pharmacophores
Macrocyclic alkaloids
Quinolines
β -Carboline alkaloids
Piperidine alkaloids and phenol derivatives
Pyrroles
Xanthones
Phloroglucinols
Quinones
Anthraquinones
Macrolides
Terpenes
Cyclodepsipeptides as antiplasmodial compounds
Natural compounds and their mosquitocidal potential
Conclusion
Acknowledgment
References
Index
Back Cover
