Burns can cause life-threatening injury and the lengthy hospitalization and rehabilitations required in burn therapy lead to higher healthcare costs. The risk of infection has also been one of the important concerns of burn wound management. The purpose of the burn wound care management is speedy wound healing and epithelization to limit the infection. The topical application of therapeutic agents is quintessential for the longevity of patients having significant burns.
In recent times, research on herbal medicine for burn wound management has been vastly increased because of their safer toxicological profiles in contrast to synthetic medicines. Despite the promising therapeutic potential of herbal medicines in this area, herbal medications have some limitations which include low pharmacological activity, solubility and stability. Nanotechnology-based smart drug delivery approaches which involve the use of small molecules as nanocarriers, however, can help to overcome these biopharmaceutical challenges.
This book provides an overview of plant-mediated metallic nanoparticulate systems and nanophytomedicine based therapeutic treatment modalities for burn wound lesions. Nine chapters deliver updated information about nanomedicines for burn wound therapy. Contributions are written by experts in nanomedicine and phytomedicine and collectively cover the pathophysiology of wound lesions, current and future outlook of nanomedicine based treatments for burn wound lesions, the role of biocompatible nanomaterials in burn wound management, plant-mediated synthesis of metal nanoparticles for treating burn wound sepsis, phytomedicine based nanoformulations and the phyto-informatics models involved in the wound healing process which are used to select appropriate nanotherapeutic agents.
This reference serves as an accessible source of information on the topic of nanomedicine for burn treatments for all healthcare professionals (medical doctors, nurses, students trainees) and researchers in allied fields (pharmacology, phytomedicine) who are interested in this area of medicine.
Author(s): Md. Abul Barkat, Sarwar Beg, Farhan Jalees Ahmad
Publisher: Bentham Science Publishers
Year: 2021
Language: English
Pages: 193
City: Singapore
Cover
Title
Copyright
End User License Agreement
Contents
Foreword
Preface
List of Contributors
Current Status and Future Outlook of Nanotechnology-Based Therapeutic Treatment Modalities for Burn Wound Management
Rana Mazumder1 and Subhabrota Majumdar2,*
INTRODUCTION
Skin
Physiology for Burn Wounds
Burn Wound Healing
NANOMEDICINE AND ADVANCEMENT IN THERAPY FOR BURN WOUND MANAGEMENT
Metallic Nanoparticles
Polymeric Nanoparticles
Liposomal Nanoparticles
Nanoemulsion
Nanogels
Wound Dressings
Tissue Engineering
Nanostructured Topical Drug Delivery Recent Advancement as Burn Wound Therapy
CONCLUDING REMARKS AND FUTURE PROSPECT
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Nanotechnology- Mediated Delivery of Phytomedicine for Burn Wound Healing
Mohammed Aslam1, Mohammad Zaki Ahmad2, Abdul Aleem Mohammed2, Harshita3,4, Md. Abul Barkat4 and Javed Ahmad2,*
INTRODUCTION
SIGNIFICANCE OF NANOTECHNOLOGY-MEDIATED DELIVERY OF PHYTOMEDICINE
DELIVERY OF PHYTOMEDICINE EXPLOITING NANOTECHNOLOGY IN BURN WOUND HEALING
Berberine
Bromelain
Silymarin
Madecassoside
Resveratrol
Epigallocatechin
Curcumin
Aloe vera
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Plant Mediated Green Synthesis of Silver Nanoparticles for Burn Wound Infections
Katayoon Kalantari1,*, Alireza Kalantari2 and Thomas J. Webster1
INTRODUCTION
Plant-Based Synthesis of Ag-NPs
Mechanism of Plant-Mediated Synthesis of Ag-NPs
Ag-NP Characterization Techniques
Cytotoxicity of Plant-Mediated Ag-NPs
Antimicrobial Activities of Plant-Mediated Ag-NPs
Wound Healing Process
Wound Healing Applications of Ag-NPs
Side Effects of Silver Use
SUMMARY AND FUTURE PROSPECTS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Therapeutic Prospective of Green-synthesized Silver Nanoparticles in Burn Wound Management
S. Sumathi1,*
INTRODUCTION
Wound Healing
AgNPs as Antimicrobial Agents
Green Synthesis of AgNPs
Characterization of AgNPs and its Applications
Plant Mediated Synthesis of AgNPs and its Wound Healing Activity
Microbial Organism Mediated AgNPs and its Wound Healing Activity
Mechanism of Action of Antibacterial Activity
CONCLUDING REMARKS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCE
Phytochemical-Assisted Gold Nanoparticles for Burn Wound Management
Abdelgadir A. Abdelgadir1 and Pooja A. Chawla2,*
INTRODUCTION
GOLD NANOPARTICLES POTENTIAL THERAPEUTIC EFFECTS ON WOUND HEALING
GREEN SYNTHESIS OF GOLD NANOPARTICLES AND CHARACTERIZATION
WOUND HEALING MECHANISM OF PHYTOCHEMICAL-ASSISTEDGOLD NANOPARTICLES
In Vitro Studies
In Vivo Studies
CONCLUDING REMARKS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Therapeutic Importance of Phyto-assisted Green Synthesis of Zinc Oxide Nanoparticles in Burn Wound Management
Md. Abul Barkat1,*
INTRODUCTION
Phyto-assisted Green Synthesis of Zinc Oxide Nanoparticles
Therapeutic Potential of Phyto-assisted ZnONPs in Burn Wound
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Plant Mediated Synthesis of Titanium Dioxide Nanoparticles for Burn Wound Management
Abdelgadir A. Abdelgadir1 and Pooja A. Chawla2,*
INTRODUCTION
NANOPARTICLE’S POTENTIAL THERAPEUTIC EFFECTS ON WOUND HEALING
GREEN SYNTHESIS OF TITANIUM DIOXIDE NANOPARTICLES AND CHARACTERIZATION
TITANIUM DIOXIDE PLANT-BASED NANOPARTICLES
APPLICATIONS OF PLANT TITANIUM DIOXIDE NANOPARTICLES FOR WOUND HEALING
In vitro Studies
In vivo Studies
CONCLUDING REMARKS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Toxicity Related to Phytochemical-assisted Metallic Nanoparticles in Burn Wound Management
Lubna Abidin1, Mohd. Mujeeb1,* and Md. Abul Barkat2
INTRODUCTION
CLASSIFICATION OF BURN WOUNDS
THE RESTORATION CASCADE
NANOPARTICLES IN BURN WOUND TREATMENT
PENETRATION OF PMNPS THROUGH DERMAL ROUTE
Intracellular Pathway
Intercellular Pathway
Follicular Pathway
TOXICITY CAUSED BY PMNPS IN BURN WOUNDS
Mechanism of PMNPs Toxicity
Production of ROS
Inflammatory Cascade
Genotoxicity
Autophagy
Apoptosis
Epigenetic Effects
Phototoxicity
Neurotoxicity
Skin Sensitivity by Metallic NPs
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMNT
REFERENCES
A Novel Herbal Informatic Approach for the Management of Skin Burn Injury
Ankit Tanwar1,*, Ruby Sharma2, Ayesha Ali Zaidi3, Deepti Sharma4, Rashmi Wardhan6, Raman Chawla4, Himanshu Ojha4, Rajesh Arora5 and Haider Ali Khan3
INTRODUCTION
Types of Wounds and Their Healing Mechanism
Side Effects of Skin Burn Injury
Biomarkers of the Skin Wounds
METHODOLOGY
Classic Literature Surge Model
Evaluation of Relevance Factor Using ‘Keywords Hits’ Scoring Matrix Approach
Binary Coefficients Matrix to Assess the Presence/Absence of a Bioactivity Parameter (BAP)
Weightage Matrix-Based Analysis
Fuzzy Set Optimization for the Decision Matrix
RESULTS
Bioactivity Parameters Analysis Using the Classical Approach
Keywords Hit Scoring Matrix Approach to Evaluate the Relevance Factor
Simple Additive Weighting Matrix
Decision Matrix-Based Optimization
DISCUSSION
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICTS OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Subject Index
Back Cover
