The book is an introduction to nanomedicine informed by a philosophical reflection about the domain and recent developments. It is an overview of the field, sketching out the main areas of current investment and research. The authors present some case-studies illustrating the different areas of research (nanopharmacy, theranostics and patient monitoring) as well as reflecting on the risks that accompany it, such as unanticipated impacts on human health and environmental toxicity. This introduction to a fast-growing field in modern medical research is of great interest to researchers working in many disciplines as well as the general public. In addition to an overview of the work currently ongoing, the authors critically assess these projects from an ethical and philosophical perspective.
Key Features
- Provides an overview of nanomedicine
- Employs a reflective and coherent critical evaluation of the benefits and risks of nanomedicine
- Written in an accessible manner intended for a wide audience
Related Titles
Hehenberger, M. Nanomedicine: Science, Business, and impact (ISBN 978-9-8146-1376-7).
Beg, S., et al. Nanomedicine for the treatment of Disease: From Concept to Application (ISBN 978-1-7746-3443-1)
Brenner, S. The Clinical Nanomedicine Handbook (ISBN 978-1-1380-7578-8)
Author(s): Jonathan Simon, Bertrand Rihn
Publisher: CRC Press
Year: 2023
Language: English
Pages: 173
City: Boca Raton
Cover
Half Title
Title
Copyright
Contents
Authors
Chapter 1 Introduction
1.1 What Is Nano?
1.2 The Structure
1.3 The Place of Novelty in Innovation
1.4 The Definition of Nanomedicine
1.5 Can the Definition of the Nano (Nanosciences and Nanotechnology) Be Limited to Size?
1.6 To Go Further
1.7 References
Chapter 2 Nanopharmacy: What Is New With the Nano?
2.1 The Nanomedical Strategy
2.2 Isn’t Everything Nano?
2.3 Titanium and Other Nano-metals
2.4 Nanopharmaceuticals by Design
2.5 The Bottom-up Paradigm of Molecular Design Applied to Drugs
2.6 From Empirical Plant-Based Recipes to Industrial Products: Ushering in a New Era of Chemotherapy?
2.7 Paul Ehrlich, Magic Bullets, Receptors, and the Lock and Key Analogy
2.8 Nanopharmacy as Drug Design
2.9 Vectors and Encapsulation
2.10 Basic Nanomaterials: Chylomicrons, Micelles and Liposomes
2.11 Man-Made Micelles and Liposomes
2.12 The First Generation—Liposomal Vectors
2.13 The Second Generation—PEGylation
2.14 The Third Generation—Nanomaterials With Specifically Modified Surfaces
2.14.1 Multi-functional Vectors
2.14.2 Albumin as the New Nanoparticle Standard
2.15 Is Nanopharmacy a Medical Revolution?
2.16 Pharmacy Is Not Always What It Seems
2.17 To Go Further
2.18 References
Chapter 3 Theranostics: Toward a New Integrative Horizon
3.1 Theranostics—A Broad Definition
3.2 Breast Cancer: Appropriate Treatments for Different Tumors
3.3 Radioligand Therapy—The Dual Functionality of Radioactivity
3.4 Remote Guidance and Imaging—The Theranostic Potential of Magnetic Nanoparticles
3.5 The Prostate-Specific Antigen (PSA) and Prostate Cancer
3.6 Transferrin and Biological Barriers. Another Form of Theranostics?
3.7 Visualizing Folate Receptors During Surgery
3.8 Diagnosis and Treatment: The Dawning of a New Era?
3.9 Theranostics and Precision Medicine: Refining and Individualizing Treatment
3.10 Genetics and Cancer
3.11 To Go Further
3.12 References
Chapter 4 Health Under Surveillance
4.1 In Vivo, In Vitro, In Silico: The Inversion of Scales in Genetic Analysis
4.1.1 Probes—A Future Outside the Array?
4.1.2 NBIC Convergence and Nanoelectronics
4.2 To Go Further
4.3 References
Chapter 5 Genetic Nanomedicine
5.1 Using Nanoparticles to Integrate Elements of Nucleic Acids Into Cells
5.2 The Use of NPs for Vaccination Against Infectious Diseases
5.2.1 How Vaccines Fit Into Nanomedicine
5.3 References
Chapter 6 Toxicology of Nanomaterials: A New Toxicology?
6.1 New Methods, New Possibilities, New Investigations
6.2 Entry Into the Body: The Three Principal Routes
6.2.1 The Skin
6.2.2 The Lungs
6.2.3 The Intestines
6.3 The Blood-Brain Barrier: An Inner Frontier
6.4 The Distribution of Nanoparticles in the Body
6.4.1 The Metabolism of Nanoparticles
6.4.2 The Elimination of Nanoparticles
6.5 Cell Response
6.5.1 How Nanoparticles Enter the Cells?
6.5.2 Cellular Reactions to Nanoparticles
6.6 The Paradox of the Dose–Function Relationship With Nanoparticles
6.6.1 New Paradigms for the Toxicological Testing of Nanoparticles
6.7 How to Express Dose?
6.8 Immune Paralysis by Overloading
6.9 Biopersistency* and ‘Frustrated Phagocytosis’
6.10 The Corona of Nanoparticles
6.11 Are Stealthy Nanoparticles a Myth?
6.12 To Go Further
6.13 References
Chapter 7 Organs on Chips, Miniaturization and Medical Specialties: The Different Logics of Nanomedicine
7.1 The Goals and Limits of Miniaturization
7.2 Miniaturizing Organisms and Organs. The Possibilities and the Limits
7.3 From the Lab(oratory)-on-a-Chip to the Organ-on-a-Chip
7.4 The Organ-on-a-Chip: Is the Future of Metabolic Testing Already Here?
7.5 Lung Cells
7.6 Heart Cells
7.7 Skin
7.8 Multiple Organs
7.9 Organs on Chips and the Nano
7.10 Why Do We Need Organs on Chips?
7.11 Tumors on Chips
7.12 Miniaturization and the Nano
7.13 Nanomedicine as a Distributed Approach to Medical Specialties
7.14 To Go Further
7.15 References
Chapter 8 Regenerative Medicine: Mobilizing the Body’s Own Repair Mechanisms
8.1 The Potential of the Stem Cells Behind Regenerative Medicine
8.2 Replacing Missing Bone as a Nano-architectural, Functional Challenge
8.2.1 Nanoparticles, Nanotubes and Nanofibers
8.2.2 Carbon Nanomaterials
8.2.3 Graphene—A Flagship Nano-material
8.2.4 Peptide Amphiphiles
8.2.5 Hydrogels
8.2.6 Magnetic Scaffolds
8.3 Mesenchymal Stem Cells—The Key to Regenerative Medicine
8.3.1 Diseases of the Bones and Joints
8.3.2 Heart Disease
8.4 Angiogenesis
8.5 The Potential of Stem Cells
8.6 From Replacement to Enhancement
8.7 Autologous Organ Transplantation
8.8 To Go Further
8.9 References
Chapter 9 Conclusion
9.1 References
Glossary
Index
