The field of nanocatalysis is undergoing rapid development. Nanocatalysis can help in designing catalysts with excellent activity, greater selectivity, and high stability. Their properties can easily be tuned by tailoring the size, shape, and morphology of the particular nanomaterial. Exhibiting both homogeneous and heterogeneous catalytic properties, nanocatalysts allow for rapid and selective chemical transformations, with the benefits of excellent product yield and ease of catalyst separation and recovery.
Nanocatalysis: Synthesis of Bioactive Heterocycles reviews the catalytic performance and the synthesis and characterization of nanocatalysts, examining the current state of the art and pointing the way towards new avenues of research specially synthesis of bioactive heterocycles.
Top researchers summarize synthetic methodologies for the synthesis of bioactive heterocycles using a nanocatalytic framework. The catalytic performance and the synthesis and characterization of nanocatalysts are reviewed. State of the art methods and new and emerging applications of nanocatalysts in the synthesis of biologically active heterocycles are detailed. Additional features include:
- Focuses on designing and synthesizing nanocatalysts specifically for the synthesis of different bioactive heterocycles.
- Demonstrates how nanocatalysis can produce catalysts with excellent activity, greater selectivity, and high stability.
- Explores tuning catalysts properties by tailoring the size, shape, and morphology of a nanomaterial.
- Offers the reader insights into the field of nanoscience via nanocatalysis.
Nanocatalysis: Synthesis of Bioactive Heterocycles is a must read for researchers in organic chemistry, medicinal chemistry and biochemistry.
Author(s): Keshav Lalit Ameta, Ravi Kant
Publisher: CRC Press
Year: 2022
Language: English
Pages: 267
City: Boca Raton
Cover
Half Title
Title Page
Copyright Page
Table of Contents
Figures
Tables
Preface
Contributors
About the Editors
1 Nanocatalysed Synthesis of Lactams
1.1 Introduction
1.2 Gold Nanoparticles
1.2.1 Polymer Confined Carbon Black–Gold and Gold and Cobalt Nanoparticles
1.2.2 Gold–Titania Catalyst for the Synthesis of Caprolactam
1.2.3 Gold-Palladium Nanocatalyst
1.2.4 Poly (N-Vinyl-2-Pyrrolidone)-Stabilized Nano Gold
1.3 Catalytic Applications of Copper Nanoparticles
1.3.1 Copper Ferrite Nanoparticles
1.3.2 Biogenic Copper (II) Oxide Nanoparticles for C–N Cross-Coupling
1.3.3 Copper (II) Oxide Nanoparticles to Couple Amines to Pyrrolidinone
1.4 Platinum Nanoparticles for the Synthesis of Lactam
1.4.1 Platinum and Phosphoros–Titanium Dioxide Nanocatalysts for the Synthesis of Pyrrolidones From Levulinic Acid
1.4.2 Heterogeneous Platinum Catalysts for Synthesis of G-Lactams From Nitrile
1.5 Iron (III) Oxide Nanoparticles for the Synthesis of .-Lactam That Contains an Aryl Amino Group
1.6 Conclusions
References
2 Recent Advances in Nanocatalyzed Synthesis of Seven-Member N-Heterocyclic Compounds With Special Reference to Azepines, Benzoazepines, Benzodiazepines, and Their Derivatives: A Brief Review
2.1 Introduction
2.2 Seven-Membered Systems That Contain One Hetero Atom
2.2.1 Azepines and Derivatives
2.2.2 Benzazepines and Derivatives
2.3 Seven-Membered Systems That Contains Two Heteroatoms
2.3.1 Benzodiazepines and Derivatives
2.3.2 Synthetic Approaches of Benzodiazepines
2.3.3 Methods for the Synthesis of 1, 5-Benzodiazepine Derivatives
2.3.4 Methods for the Synthesis of 1,4-Benzodiazepines
2.4 Synthetic Approaches for Fused Benzodiazepines
2.5 Conclusions and Future Perspectives
References
3 An Overview of the Synthesis of Pyrroline, Indolizine, and Quinolizinium Derivatives Using Different Nanocatalysts
3.1 Introduction
3.1.1 Pyrroline
3.1.2 Synthesis of 1-Pyrrolines By Gold Catalysis
3.2 Indolizine
3.2.1 General Procedure for Preparation of Indolizines
3.2.2 Inhibitory Activities of Indolizine Derivatives
3.2.2.1 Anticancer Activity
3.2.2.2 Antiviral Activity
3.2.2.3 Anti-Inflammatory Activity
3.2.2.4 Antimicrobial Agents
3.2.2.5 Antitubercular Activity
3.3 Quinolizinium Salts
3.4 Conclusion
References
4 Nanocatalyzed Synthesis of Bioactive Pyrrole, Indole, Furan, and Benzofuran Derived Heterocycles
4.1 INTRODUCTION
4.1.1 Introduction of Pyrroles
4.1.2 Synthesis of Pyrrole Derivatives Using Nanocatalyst
4.2 INTRODUCTION TO INDOLE
4.2.1 Synthesis of Indole Derivatives Using Nanocatalysts
4.3 Introduction to Furan
4.3.1 Synthesis of Furan Derivatives Using Nanocatalysts
4.4 Introduction to Benzofuran
4.4.1 Synthesis of Benzofuran Using Nanocatalysts
4.5 Conclusion
References
5 Cheaper Transition Metals-Based Nanocatalyzed Organic Transformations and Synthesis of Bioactive Heterocycles Strategic Approaches and Sustainable Applications
5.1 INTRODUCTION
5.2 CHEAPER TRANSITION METAL NANOPARTICLE ASSISTED ORGANIC TRANSFORMATIONS
5.2.1 Cobalt Or Cobalt–Ferrite Based Nanoparticle Assisted Organic Transformations and Synthesis of Bioactive Heterocycles
5.2.1.1 N-Doped Carbon-Supported Cobalt Nanoparticle Catalyzed Synthesis of N-Heterocyclic Compounds
5.2.1.2 Co-Phen@C Catalyzed Reversible Acceptorless Dehydrogenation and Hydrogenation of Various N-Heterocycles
5.2.1.3 Co@NCNTs Catalyzed Oxidative Dehydrogenation of Various N-Containing Heterocycles
5.2.1.4 Co/N–Si–C Catalyzed Synthesis of (E)-2-Alkenyl-Azaarenes
5.2.1.5 Co@NGS-800 Catalyzed Oxidative Dehydrogenation and Hydrogenation of Quinolones
5.2.1.6 Co–NHC@MWCNTs Catalyzed Synthesis of Various Propargylamines and 1,2-Diphenylethyne
5.2.1.7 CoNP@SBA-15 Catalyzed Synthesis of 1,8-Dioxo-Octahydroxanthenes
5.2.1.8 Cobalt-Terephthalic Acid Metal–organic Framework Catalyzed Hydrogenation of Bioactive N-Heterocycles
5.2.1.9 CoFe2O4-Based Nanocatalyst for the Oxidation of Alcohols
5.2.1.10 CrCoFeO4@G–GO and Zn0.5Co0.5Fe2O4@G–GO as an Efficient Nanocatalyst for Oxidation Reactions
5.2.1.11 CoFe2O4/CNT-Cu Catalyzed Synthesis of 3-Nitro-2-Arylimidazo [1,2-A]pyridines
5.2.1.12 Nanoparticle CoFe2O4-Catalyzed Synthesis of Benzimidazoles
5.2.1.13 CoFe2O4 Catalyzed Synthesis of Benzimidazoles and Benzoxazoles
5.2.1.14 CoFe2O4@SiO2/PrNH2 as an Efficient Nanocatalytic System for Multicomponent Reactions
5.2.1.15 CoFe2O4-GO-SO3H Catalyzed Synthesis of 3,6-Di(pyridin-3-Yl)-1H-Pyrazolo[3,4-B]pyridine-5-Carbonitriles
5.2.1.16 CoFe2O4 Nanoparticles Three-Component Reaction Using Greener Reaction Conditions
5.2.1.17 CoFe2O4@SiO2–PTA Catalyzed N-Formylation of Amines
5.2.1.18 Co@NGR Nanocatalyst Hydrogenation of Alkynes
5.2.1.19 Co Nanoparticles Catalyzed Hydrogenation of Bioactive Heterocycles
5.2.1.20 Co/MA-800 Catalyzed Hydrogenation of Nitroarenes to Aminoarenes and Some Bioactive Heterocycles
5.2.2 Nickel Nanoparticle Catalyzed Organic Transformations and Synthesis of Bioactive Heterocycles
5.2.2.1 Diphenylphosphinated Poly(vinyl Alcohol-Co-Ethylene)-Nickel Nanoparticle Catalyzed Mizoroki–Heck Reaction
5.2.2.2 Ni(II)– DABCO@SiO2 as an Efficient Heterogeneous Nanocatalyst for Heck Reaction
5.2.2.3 Fe3O4@SiO2-EDTA-Ni(0) Nanoparticle Catalyzed Suzuki-Miyuara and Heck Cross-Coupling
5.2.2.4 Nickel Nanoparticles in [BMMIM]NTf2 Catalyzed Nitrile Hydrogenation
5.2.2.5 Nano-NiFe2O4 Catalyzed Synthesis of Alkoxyimidazo[1,2-A]pyridines
5.2.2.6 Nickel Nanoparticle Catalyzed Multicomponent Reaction for the Synthesis of Pyrrole
5.2.2.7 Nickel Nanoparticle Catalyzed Stereo- and Chemo-Selective Semihydrogenation of Functionalized Alkynes of Structurally Diverse
5.2.2.8 Resin-Encapsulated Nickel Nanocatalyst for the Reduction of Nitroarenes
5.2.2.9 NiFe2O4@SiO2–H3PW12O40 Catalyzed Synthesis of Tetrahydrobenzo[b].pyran and Pyrano[2,3-C]pyrazoles
5.2.2.10 PdRuNi@GO NPs Assisted Synthesis of Hantzsch 1, 4-Dihydropyridines
5.2.3 Copper Nanoparticle Catalyzed Organic Transformations and Synthesis of Bioactive Heterocycles
5.2.3.1 Heterogenous Recyclable Copper(0) Nanoparticle Deposited On Nanoporous Polymer Catalytic System for Ullman Reaction in Water
5.2.3.2 Solvent-Dependent CuNPs/C Catalyzed Multicomponent Synthesis of Indolizines and Chalcones
5.2.3.3 Cu3(BTC)2 Derived CuNPs Immobilized On Activated Charcoal as an Efficient Nanocatalyst for the Synthesis of Unsymmetrical Chalcogenides Under Ligand-, Base-, and Additive-Free Conditions Via Se(Te)-Se(Te) Bond Activation
5.2.3.4 Cu/CuNPs Catalyzed Synthesis of Aryl Nitrile and 1,2,3-Triazoles
5.2.3.5 Cu–Ferrite NPs Catalyzed Direct, One-Pot Redox Synthesis of 2-Substituted Benzoxazoles
5.2.3.6 CuFe2O4 Catalyzed Multicomponent Synthesis of Chromeno[4,3-B]pyrrol-4(1H)-One in Aqueous Media
5.2.3.7 CuFe2O4 Nanoparticle Catalyzed Synthesis of Naphthoxazinones
5.2.3.8 CuFe2O4@SiO2-SO3H Nanoparticles Catalyzed Synthesis of 2-Pyrazole-3-Amino-Imidazo[1,2-A]pyridines-Based Heterocycles
5.2.3.9 Cu-ACP-Am-Fe3O4@SiO2 Catalyzed Huisgen 1,3-Dipolar Cycloaddition Reaction
5.2.3.10 Cu@TiO2 Nanocatalyzed C-2 Amination of Benzothiazoles, Benzoxazoles, and Thiazoles
5.3 Discussion and Summary
5.4 Conclusion
5.5 Declarations
Authors’ Contributions
Acknowledgments
LIST OF ABBREVIATIONS
References
6 Nanocatalysis: An Efficient Tool for the Synthesis of Triazines and Tetrazines
6.1 Triazines
6.1.2 Synthesis
6.2 Tetrazine
6.2.1 Synthesis
6.3 Conclusion
References
7 Synthesis of Quinolines, Isoquinolines, and Quinolones Using Various Nanocatalysts
7.1 Introduction
7.2 Quinolines
7.3 Synthesis of Quinoline and Its Derivatives
7.3.1 Using Salen Catalyst
7.3.2 TiO2-Al2O3-ZrO2 Nanocatalyst
7.3.3 Fe3O4@SiO2-APTES-TFA Nanocatalyst
7.3.4 Copper-Based Nanocatalyst
7.3.5 Cobalt-Based Nanocatalyst
7.3.6 Iron-Based Nanocatalyst
7.3.7 Manganese-Based Nanocatalyst
7.3.8 KF/CPs Nanocatalyst
7.3.9 Silver-Based Nanocatalyst
7.3.10 Nickel-Based Nanocatalyst
7.4 Isoquinolines
7.5 Synthesis of Isoquinoline and Its Derivatives
7.5.1 Iron-Based Nanocatalyst
7.5.2 Zinc-Based Nanocatalyst
7.5.3 KF/clinoptilolite Nanocatalysts
7.5.4 Copper-Based Nanocatalyst
7.6 Quinolone
7.7 Synthesis of Quinolone and Its Derivatives
7.7.1 Polystyrene-Supported Palladium Nanocatalyst
7.7.2 Supramolecular Assemblies and Mercury Nanocatalysts
7.7.3 Titanium-Based Nanocatalyst
7.7.4 SBA-15/PrN(CH2PO3H)2 as Nanocatalyst
7.7.5 Copper-Based Nanocatalyst
7.7.6 Zirconium-Based Nanocatalyst
7.7.7 Iron-Based Nanocatalyst
7.7.8 Cadmium-Based Nanocatalyst
7.8 Conclusion
References
8 Recent Advances in Nanocatalyzed Synthesis of Triazoles and Tetrazoles and Their Biological Studies
8.1 Introduction
8.2 Biological Significance of Triazoles and Tetrazoles
8.3 Recent Developments in the Nanomaterial Catalyzed Synthesis of Triazoles and Tetrazoles
8.4 Conclusion
References
9 Nanocatalysed Synthesis and Biological Significance of Imidazoles, Hydantoins, Oxazoles, and Thiazoles
9.1 Introduction
9.2 Imidazole
9.2.1 Synthesis of Imidazole and Benzimidazole Derivatives
9.3 Hydantoin
9.3.1 Synthesis of Hydantoin Derivatives
9.4 Oxazoles
9.4.1 Synthesis of Oxazole and Benzoxazole Derivatives
9.5 Thiazoles
9.5.1 Synthesis of Thiazole and Benzothiazole Derivatives
9.6 Conclusion
References
10 Nanocatalysed Synthesis of Pyrazoles, Indazoles, and Pyrazolines
10.1 Introduction
10.1.1 Pyrazoles
10.1.2 Indazoles
10.1.3 Pyrazoline
10.2 Synthetic Aspects Associated With Nanomaterials
10.2.1 Synthesis of Pyrazole Derivatives By Nanocatalysis
10.2.2 Nanocatalyzed Synthesis of Indazole Derivatives
10.2.3 Synthesis of Pyrazolines With the Support of a Nanocatalyst
10.3 Conclusions
References
Index
