mRNA Vaccine Toxicity

Front matter
Copyright
Dedication
Contents
List of Figures
List of Tables
Foreword by Mary Holland
Preface
Introduction
Are mRNA vaccines dangerous in principle, or is the observed harm accidental?
COVID-19 vaccines were never about your health
The misuse of emergency use authorizations, and the breakdown of regulatory safeguards
Why this book was written
Some elements of virology and immunology
The life cycle of a virus
Cellular vs. viral genome structure and protein expression
The role of cellular receptor proteins in virus multiplication
Some viruses are surrounded by a membrane envelope
Immunity to viruses
Antiviral immune effector mechanisms
The activation of an antiviral immune response
Specific immune responses are initiated by the non-specific immune system
Activation of cytotoxic T-cells
Activation of antibody production
The antibody class switch
How do the highly diverse T-cell and B-cell reservoirs originate?
Immunological memory
Cross-immunity
Who really controls viral infections: antibodies, or cytotoxic T-cells?
Primary vs. secondary immune response
Antibody-dependent enhancement
Viral evasion of T-cell cytotoxicity
Immunity to respiratory viruses: systemic versus mucosal immunity
Vaccination strategies
``Dead'' vaccines
Live virus vaccines
Atypically severe infection in susceptible individuals
Transmission of the vaccine virus in the human population
Reversion of the attenuated virus strain to full virulence for humans
Gene-based vaccines
Adenovirus-based vaccines
mRNA vaccines
The immune response induced by gene-based vaccines
Degrees of vaccine-induced immunity, and rationales for vaccination
Appendix: some evidence of fraud in Pfizer's clinical trials
Immunological mechanisms of harm by mRNA vaccines
mRNA vaccines are distributed throughout the body and prominently affect the blood vessels
The expression of spike protein in the body is widespread and long-lasting
The mRNA vaccine LNPs fly under the radar of the immune system
Induction of autoimmune disease
Background
Autoimmune disease induced by infections
Deficient clearance of self antigens released from deceased cells
Autoimmune diseases induced by COVID-19 vaccines
Vaccine-induced immunosuppression
Manifestations of immunosuppression after COVID-19 vaccination
Possible mechanisms
Saturated bandwidth
Lymphocyte fratricide
Immunosuppression by lipid nanoparticles
The fundamental mechanism of damage by mRNA vaccines is completely general
Pathological evidence of immunological harm due to mRNA vaccines
Key techniques used in histopathology
Chemical staining
Immunohistochemistry
Sources of evidence
Vasculitis induced by mRNA vaccination
Vaccine-induced expression of spike protein in vascular endothelia
Vasculitis, blood clots, and dissection: example autopsy findings
Aortic dissection and rupture
Blood clots
Variability of vasculitis
The role of spike protein toxicity in vasculitis and clotting
Immune attack on organ-specific cells and tissues
Myocarditis
Lung inflammation (pneumonitis)
Brain inflammation (encephalitis)
Encephalitis due to an immune reaction against spike protein
Autoimmune encephalitis
Antibody-negative autoimmune encephalitis
Liver inflammation (hepatitis)
Viral hepatitis
Toxic hepatitis
Autoimmune hepatitis
Autoimmunity in viral and toxic hepatitis
What effects on the liver should we expect with mRNA vaccines?
Evidence of vaccine mRNA and its expression in post-vaccination hepatitis
Clinical case reports on mRNA vaccine-induced hepatitis
Kidney disease
Involvement of the spleen
Skin manifestations
Other organs
Pharmacokinetics and lipid toxicity of mRNA vaccines
Structure and function of lipid nanoparticles
The biomolecular corona
Receptor-mediated endocytosis and transcytosis of lipoproteins
Traversal of vascular barriers by lipid nanoparticles
Intracellular release of the mRNA
Pharmacokinetics of mRNA vaccines
Organ distribution of model mRNA vaccines
Correlation of model vaccine organ distribution with histopathological findings
Time course of elimination and duration of activity
Time course of mRNA elimination
Time course of lipid elimination
Accidental intravascular injection
Lipid nanoparticle toxicity
Allergic reactions caused by PEG-conjugated lipids
Inflammatory signaling by cationic lipids
Chemical toxicity of cationic lipids
Cationic lipids induce reactive oxygen species
DNA damage is cumulative
Toxicity of experimental or approved LNP drugs and vaccines
Appendix: Evidence of substandard manufacturing quality of COVID-19 mRNA vaccines
Contaminants detected in mRNA vaccines
Metallic particles
Plasmid DNA
Other contaminants
Lipid impurities
Implications
Batch-to-batch variability of adverse event reports
Genotoxicity of mRNA vaccines
Genotoxicity of synthetic cationic lipids
Increased abundance of polychromatic red blood cells
Increased abundance of micronuclei
Conclusion
Reverse transcription of vaccine mRNA sequences into DNA
The genotoxicity risks of recombinant RNA were dismissed based on outdated science
Genomic insertion of RNA viruses through cellular reverse transcriptase activities
The biological role of cellular retrotransposons
Genomic DNA sequences derived from non-retroviral RNA viruses
Genomic insertion of SARS-CoV-2 sequences in infected cells
Detection of spike gene DNA copies in vaccine-exposed cells
Detection of intracellular DNA encoding spike protein does not distinguish between retrotransposition and direct transfection
Conclusion
Contaminating plasmid DNA in Pfizer's and Moderna's mRNA vaccines
Known and plausible risks posed by DNA copies of non-self genes
Chromosomal integration of the non-self gene
Biological consequences of DNA insertion
Gene inactivation
Gene regulation
Activation of oncogenes
Plasmid DNA may immortalize cell cultures
Expression of the inserted gene
Germline integration
Persistent expression of the foreign antigen
Epidemiology of COVID-19 mRNA Vaccine Adverse Events
Introduction
General Adverse Events, Serious Adverse Events, Death, Hospitalization, Life-Threatening Events
Clinical Trial Data Analyses
Post-Marketing Surveillance Data Analyses
Vaccinated vs. Unvaccinated Cohort Analysis
Summary
Cardiac Events
Surveillance Data Analyses
Vaccinated vs. Unvaccinated Cohort Analyses
Other Cohort Analyses
Summary
Thrombotic Events
Summary
Neurological Events
Hemorrhagic Stroke
Bell's Palsy
Sensorineural Hearing Loss
Summary
Immunological Events
Summary
Reproductive Events
Absence of Clinical Trial Pregnancy Data
Passive Surveillance Analyses
Menstrual Survey Analyses
Vaccinated vs. Unvaccinated Cohort Analyses
Male Fertility Analysis
Summary
Conclusion
AIDS & HIV: The Blueprint for the Perversion of Medical Science
AIDS does not behave like a novel contagious disease
AIDS and drug abuse
Peter Duesberg's scientific critique of the HIV/AIDS hypothesis
HIV is not sexually transmitted
Kary Mullis' quest for evidence that HIV causes AIDS
The crucifixion of a dissident
AIDS in Africa
Thabo Mbeki's ill-fated attempt to get at the truth about AIDS
Some evidence to challenge the AIDS orthodoxy
Summary and conclusions
The key mechanism of mRNA vaccine toxicity
The immunological mechanism of harm is completely general
Could a return to good manufacturing practices abolish the toxicity of the mRNA vaccines?
If mRNA vaccines are inherently dangerous, why are they urged and even forced on us?
What can we do?
Afterword by Catherine Austin Fitts
References