Easy to read, yet comprehensive, this is the perfect introduction into the molecular basis of disease and the novel treatment options that have become available. The authors, Jens Kurreck and Cy Stein, have both long-standing teaching experience on the subject, one from a biologist's angle, the other with a medical background. Together, they have produced a modern textbook for courses in Molecular Medicine that incorporates modules from immunology to signaling, from virology to gene therapy, and the latest development in personalized medicine.
Author(s): Jens Kurreck, Cy Aaron Stein
Publisher: Wiley-VCH
Year: 2016
Language: English
Pages: 404
City: Weinheim
Related Titles
Title Page
Copyright
Dedication
Preface
Acknowledgments
Chapter 1: Introduction
1.1 The Basics of Molecular Medicine
1.2 The Human Cell
1.3 DNA Replication and Gene Expression
1.4 Biological Communication
1.5 The Immune System
References
Chapter 2: Methods in Molecular Medicine
2.1 DNA Microarrays
2.2 Quantitative Polymerase Chain Reaction
2.3 Next-Generation Sequencing
2.4 Animal Models in Biomedical Research
2.5 Additional Methods
References
Chapter 3: Genetic Disorders
3.1 Single-Gene Disorders
3.2 Polygenic Disorders
References
Chapter 4: Molecular Oncology
4.1 Molecular Biology of Breast Cancer and Its Clinical Implications
4.2 Lung Cancer
4.3 Hepatocellular Carcinoma
4.4 Molecular Biology of Colorectal Cancer and Its Clinical Implications
4.5 Molecular Biology of Renal Cell Carcinoma
4.6 Molecular Biology of Prostate Cancer
4.7 Molecular Biology of Hematological Malignancies
References
Chapter 5: Molecular Virology
5.1 The Basics of Virology
5.2 Vaccination
5.3 Detection of Viruses
5.4 Antiviral Therapy
5.5 Prions
References
Chapter 6: Bacteria and Eukaryotic Pathogens
6.1 Bacteria
6.2 Eukaryotic Pathogens
References
Chapter 7: Genomics and Proteomics
7.1 Whole Genome Sequencing
7.2 The Human Genome
7.3 Proteomics
References
Chapter 8: Genetic Testing
8.1 Types of Genetic Tests
8.2 Chromosome Abnormalities
8.3 Molecular Diagnosis
References
Chapter 9: Pharmacogenetics/Pharmacogenomics
9.1 Uptake and Transport of Drugs
9.2 Drug Metabolism
9.3 Drug Targeting
9.4 Drug Toxicity and Hypersensitivity
9.5 Drug Development and Individual Pharmacotherapy
References
Chapter 10: Recombinant Protein Drugs
10.1 Production of Recombinant Proteins
10.2 Classes of Recombinant Drugs
References
Chapter 11: Gene Therapy
11.1 Types of Gene Therapy
11.2 Methods of Gene Transfer
11.3 Tissue Specificity of Gene Transfer and Gene Expression
11.4 Applications of Gene Therapy
11.5 Future Prospects
References
Chapter 12: Stem Cells
12.1 Embryonic Stem Cells
12.2 Adult Stem Cells
12.3 Induced Pluripotent Stem Cells
12.4 Transdifferentiation and Direct Reprogramming
12.5 Differentiation of Stem Cells
12.6 Medical Applications of Stem Cells
References
Chapter 13: Antisense, Ribozyme, and RNA Interference Strategies
13.1 Antisense Oligonucleotides
13.2 Ribozymes
13.3 RNA Interference
13.4 MicroRNAs
References
Chapter 14: Aptamers
14.1 Selection of Aptamers
14.2 Modifications of Aptamers
14.3 Clinical Development of Aptamers
14.4 Decoy and Immunostimulatory Oligonucleotides
References
Chapter 15: Ethics in Molecular Medicine
15.1 The Basis of Bioethics
15.2 Fields of Application
Abbreviations
Glossary
Index
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