Molecular Mechanisms of Nutritional Interventions and Supplements for the Management of Sexual Disfunction and Benign Prostatic Hyperplasia presents the epidemiologic data linking diet with BPH and ED, along with a deep explanation on why nutritional approaches and different macronutrients may modify the pathogenesis of the disease. Coverage includes the relevance/epidemiology of the disease, pathophysiological events causing the disease, available therapeutic options, molecular mechanisms of action of available treatments, epidemiological and intervention studies suggesting the benefit of diet as therapeutic option for BPH and ED, and potential mechanisms of action of nutritional based approaches as treatment for BPH and ED.
By combining medicine, diet and lifestyle options, this title provides a truly multidisciplinary approach to BPH and ED, making it a unique resource for those treating BPH and an irreplaceable reference guide for those in research.
Author(s): Bilal Chughtai
Publisher: Academic Press
Year: 2021
Language: English
Pages: 239
City: London
Front Cover
Molecular Mechanisms of Nutritional Interventions and Supplements for the Management of Sexual Dysfunction and Benign Prost...
Copyright Page
Contents
List of contributors
1 Introduction to benign prostatic hyperplasia
Introduction and epidemiology
Risk factors
Pathophysiology of BPH
Diagnosis and workup
Management of BPH
Overview of current literature addressing the association between diet and BPH
Conclusion
References
Further reading
2 Introduction to erectile dysfunction
Introduction
Epidemiology
Modifiable risk factors
Cardiovascular disease
Diabetes mellitus
Depression and anxiety
Other modifiable risk factors
Lower urinary tract symptoms
Nonmodifiable risk factors
Age
Race and socioeconomic status
Pathophysiology of ED
Physiology of initiating, maintaining, and terminating an erection
Pathophysiology of ED
Vasculogenic: arteriogenic
Vasculogenic: cavernosal
Neurogenic
Anatomic
Endocrinologic
Psychogenic
Pharmacologic
Workup of ED
Current treatment options for ED
Highlights and take-home messages
References
3 Diet as a risk factor and intervention for lower urinary tract symptoms secondary to benign prostatic hyperplasia
Introduction
Relationship of inflammation to LUTS/BPH
Hypogonadism and LUTS/BPH
Metabolic syndrome and LUTS/BPH
Metabolic syndrome and diet
Relationship of exercise to LUTS/BPH
Influence of fluid type and volume to LUTS/BPH
Influence of food type to LUTS/BPH
Grain/starch
Fruits and vegetables
Dairy
Protein
Zinc
Conclusion
References
4 Effects of metabolic syndrome on benign prostatic hyperplasia
Overview of metabolic syndrome
Metabolic syndrome and BPH
Hyperglycemia and BPH
Obesity and BPH
Association of hypercholesterolemia and hypertriglyceridemia with BPH
Hypertension and BPH
Highlights and take-home messages
References
Further reading
5 Effects of metabolic syndrome on erectile dysfunction
Review of established associations between metabolic syndrome and erectile dysfunction
Hyperglycemia and ED
Obesity and ED
Hypertension and ED
Association of hypercholesterolemia and hypertriglyceridemia with ED
Highlights and take-home messages
References
Further reading
6 Role of diet in the development and progression of benign prostatic hyperplasia
Current understanding of the pathophysiology
Risk factors
Modifiable
Nonmodifiable
Epidemiologic studies on diet and BPH
Overview
Role of fat intake
Role of protein intake
Carbohydrate and grain consumption
Red meat consumption
Dairy consumption
Vegetable consumption
Fruit consumption
Alcohol consumption
Consumption of assorted other foods
Diet management overview/summary for BPH
Interventional studies
Moderating fiber/fat intake
Zinc
Flaxseed
Fluted pumpkin/Telfairia occidentalis
Highlights and take-home messages
References
7 Role of diet in the development and progression of erectile dysfunction
Erectile dysfunction: A modifiable disease
Risk factors for erectile dysfunction
Dietary risk factors
Tobacco use
Cardiovascular disease
Review of the current understanding of diet management in erectile dysfunction
Mediterranean diet
Role of fat intake
Role of calories
Role of protein intake
Role of sodium intake
Role of fiber intake
Red meat consumption
Soy consumption
Nut consumption
Fruits and vegetables consumption
Alcohol consumption
Diet management overview
Highlights and take-home messages
References
8 Nutritional supplementation for benign prostatic hyperplasia
Serenoa repens (saw palmetto)
β-Sitosterol
Pygeum africanum
Cernilton
Lycopene
Vitamin D
Pomegranate
Zinc
Summary/conclusion
References
9 Nutritional supplements and erectile dysfunction
Introduction
L-Arginine
L-Citrulline
Yohimbine
Maca
Korean red ginseng
Vitamin D
Dehydroepiandrosterone
Icariin (isolated from horny goat weed or Epimedium)
Niacin
Pomegranate
Saffron
Conclusion
References
10 Eastern diet and benign prostatic hyperplasia
Diet and pathophysiology of benign prostatic hyperplasia
Vegetables
Mechanism of action
Fish
Mechanism of action
Tomatoes
Mechanism of action
Soy
Mechanism of action
Conclusion
References
11 Eastern diet and erectile dysfunction
Diet and pathophysiology of erectile dysfunction
Panax ginseng
ED, somatic symptoms, and ginseng
Mechanism of ginseng on improving symptoms of ED
Ginseng and vasculogenic ED
Ginseng and psychogenic ED
Curry powder
Chilies
Vegetables
Homocysteine and ED
Folate and psychogenic ED
Conclusion
References
Further reading
12 Western diet and benign prostatic hyperplasia
Introduction
Prevalence of BPH
Link between Western diet and BPH
Carbohydrates
Protein
Cholesterol
Vegetables and fruits
Vitamins and minerals
Vitamin A
Vitamin C
Vitamin D
Vitamin E
Zinc
Future perspectives on nutritional management of BPH
Conclusion
References
Further reading
13 Western diet and erectile dysfunction
Introduction
Relationship between the Western diet and erectile dysfunction
Erectile dysfunction and cardiovascular disease
Erectile dysfunction and obesity
Erectile dysfunction and metabolic syndrome
Dietary components and erectile dysfunction
Carbohydrates
Fatty acids and cholesterol
Dietary modifications for erectile dysfunction
Conclusion
References
Further reading
14 Effect of diet on storage symptoms in male lower urinary tract symptoms
Introduction
Fluid management
Caffeine
Carbonated beverages
Artificially sweetened beverages
Citrus and vitamin C
Alcohol
Milk
Conclusion
References
15 Effects of exercise on benign prostatic hyperplasia, lower urinary tract symptoms, and erectile dysfunction
Introduction
Metabolic syndrome and exercise
Types of exercise
Components of metabolic syndrome
Exercise and metabolic syndrome
Physical activity and BPH/LUTS
Overview of BPH and LUTS
Effects of exercise on BPH and LUTS
Proposed mechanisms for improvements in BPH with exercise
Growth of prostate epithelial cells
Exercise-induced changes in gene expression
Changes in hormone expression
Patient education and recommendations
Physical activity and ED
Review of risk factors
Pathophysiology of abnormal endothelial function in men with ED
Endothelial function
Obesity as a state of chronic inflammation
Effect of physical activity on testosterone levels
Effects of physical activity alone
Effects of physical activity in combination with PDE-5 inhibitors
Patient education and recommendations
Other nonpharmacologic lifestyle interventions
Conclusion
References
16 Conclusions and recommendations
References
Index
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