First published in 1986: This book is to help medical, pharmacy, and advanced students in science to understand the growing importance of continuously advancing biochemical concepts in human disease.
Author(s): George Feuer, Felix A. de la Iglesia
Series: CRC Revivals
Publisher: CRC Press
Year: 2019
Language: English
Pages: 257
City: Boca Raton
Cover
Title Page
Copyright Page
Preface
The Authors
Introduction
Basic Reference Books
Table of Contents
Dedication
Chapter 1: Abnormalities of Water and Electrolyte Metabolism
I. Introduction
II. Water Metabolism
A. Content
B. Metabolism and Regulation
III. Sodium Metabolism
IV. Potassium Metabolism
V. Acid-Base Metabolism
A. Intracellular Hydrogen Ion Concentration
B. Hydrogen Ion Balance
C. Respiratory Acidosis and Alkalosis
D. Metabolic Acidosis
E. Metabolic Alkalosis
VI. Calcium Metabolism
VII. Magnesium Metabolism
VIII. Phosphate Metabolism
IX. Regulation of Calcium, Magnesium, and Phosphate Metabolism
X. Assessment of Disturbed Metabolism
References
Further Reading
Chapter 2: Abnormalities of Trace Element Metabolism
I. Introduction
II. Effect of Environment and Homeostasis
III. Teratologic Effects
IV. Effects on Endocrine Organs
V. Effects on Infectious Diseases
VI. Effects on Cellular Membranes
VII. Diseases Associated with Selected Elements
A. Iron
B. Copper
C. Zinc
D. Manganese
E. Chromium
F. Selenium
G. Mercury
H. Lead
I. Cobalt
J. Nickel
K. Cadmium
L. Molybdenum
References
Further Reading
Chapter 3: Abnormalities of Cellular Organization
I. Introduction
II. Membrane Structure
A. General
B. Cytoskeletal Membrane System
III. Membrane Composition
A. Proteins
1. General
2. Molecular Organization of Membrane Proteins
B. Lipids
1. General
2. Molecular Organization of Membrane Lipids
a. Phospholipids
b. Steroids
c. Glycolipids
IV. Membrane Abnormalities in Cell Injury
A. Diseases of Membrane Transport Mechanism
1. Active Transport
2. Epithelial Transport
a. Diseases of Disturbed Transport
b. Hypophosphatemia
c. Tubular Reabsorption Defects
B. Membrane Abnormalities in Neurological Disorders
1. Synaptic Transmission Abnormalities
2. Excitable Membrane Abnormalities
C. Membrane Abnormalities in Metabolic Disorders
1. Brush Border Membrane Disorders
a. Carbohydrate-Related Abnormalities
b. Amino Acid- and Protein-Related Abnormalities
c. Renal Tubular Abnormalities
d. Secondary Brush Border Membrane Disorders
2. Platelet Membranes
3. Membrane Surface Receptors
a. Regulation and Disease
b. Role in Carcinogenesis
V. Subcellular Organelles
A. Nucleus
B. Mitochondria
1. Ischemic Injury
2. Toxic Injury
3. Genetic Diseases
C. Lysosomes
1. Thyroid Lysosomes in Disease
2. Lysosomotropic Effects
D. Endoplasmic Reticulum
1. Changes in Diseases
2. Protein Synthesis
3. Drug Metabolism
4. Metabolism of Body Constituents
5. Response to Toxic Compounds
6. Enzyme Induction
a. Enzyme Induction during Development
b. Enzyme Induction and Drug Metabolism
c. Clinical Importance of Enzyme Induction
d. Adverse Effects of Enzyme Induction
e. Enzyme Induction and Toxic Actions
f. Enzyme Induction and Gene Regulation
g. Enzyme Induction and Carcinogenesis
E. Golgi Apparatus
VI. Carcinogenesis and Cellular Organelles
A. Structural Changes
B. Interactions with Nuclear Components
VII. Interrelationship Between Cellular Organelles
VIII. Cell Shape Abnormalities
A. Erythrocyte Disorders
1. Deformation of Erythrocyte Shape
2. Hereditary Erythrocyte Disorders
3. Hemoglobinopathies Affecting Membrane Structure
4. Enzyme Deficiencies in Erythrocytes
B. Muscular Dystrophy
IX. Radiation Effects on Biomembranes
A. Effects of Exposure
B. Molecular Mechanisms of Radiation Damage
1. Protein Damage
2. Lipid Damage
3. Sugar Radiolysis
4. Effects on Membranes
5. Damage of Membrane Function
References
Further Reading
Glossary
Appendix: The International System of Units
Index
