DNA microarrays have revolutionized molecular biology and are becoming a standard tool in the field. Dov Stekel's book is a comprehensive guide to the mathematics, statistics, and computing required to use microarrays successfully. Unlike traditional molecular biology, the successful use of DNA microarrays requires the application of statistics and computing to design the arrays and experiments, and to analyze and manage the data. This book is written for researchers, clinicians, and laboratory managers.
Author(s): Dov Stekel
Edition: 1
Year: 2003
Language: English
Pages: 280
Cover......Page 1
Title Page......Page 5
Copyright......Page 6
Dedication......Page 7
Contents......Page 9
Foreword......Page 11
Preface......Page 13
Acknowledgments......Page 15
CHAPTER ONE - Microarrays: Making Them and Using Them......Page 19
CHAPTER TWO - Sequence Databases for Microarrays......Page 37
CHAPTER THREE - Computer Design of Oligonucleotide Probes......Page 61
CHAPTER FOUR - Image Processing......Page 80
CHAPTER FIVE - Normalisation......Page 91
CHAPTER SIX - Measuring and Quantifying Microarray Variability......Page 118
CHAPTER SEVEN - Analysis of Differentially Expressed Genes......Page 128
COLOR PLATES......Page 146
CHAPTER EIGHT - Analysis of Relationships Between Genes, Tissues or Treatments......Page 165
CHAPTER NINE - Classification of Tissues and Samples......Page 209
CHAPTER TEN - Experimental Design......Page 237
CHAPTER ELEVEN - Data Standards, Storage and Sharing......Page 257
APPENDIX - MIAME Glossary......Page 279
INDEX......Page 285
