This volume first considers the categories of zinc metalloenzymes, together with models of the enzymic metal-ion binding sites. It covers the nutritional aspects of zinc: its absorption and excretion, its influence on the activity of enzymes and hormones, and the zinc deficiency syndrome.
Author(s): Helmut Sigel
Publisher: CRC Press
Year: 2020
Language: English
Pages: 519
City: New York
Cover
Half Title
Title Page
Copyright Page
Table of Contents
Preface to the Series
Preface to Volume 15
Contributors
Contents of Other Volumes
Chapter 1 Categories of Zinc Metalloenzymes
1. Introduction
2. Catalytic Role of Zinc: Carbonic Anhydrase
3. Structural Role of Zinc: Aspartate Transcarbamylase
4. Regulatory and Catalytic Roles of Zinc: Leucine Aminopeptidase
5. Noncatalytic and Catalytic Roles of Zinc: Alcohol Dehydrogenase
6. General Conclusions
References
Chapter 2 Models for Zn(II) Binding Sites in Enzymes
1. Introduction
2. Carbonic Anhydrase
3. Peptidases: Carboxypeptidase and Thermolysin
4. Alcohol Dehydrogenase
5. Alkaline Phosphatase
6. Superoxide Dismutase
7. Conclusion
References
Chapter 3 An Insight on the Active Site of Zinc Enzymes Through Metal Substitution
1. Introduction
2. Zinc(II) in Metalloenzymes
3. Zinc Substitution and General Remarks on the Metal Derivatives
4. Cobalt(II) Derivatives
5. Copper(II) Derivatives
6. Manganese(II) Derivatives
7. Cadmium(II) Derivatives
8. Other Metal Derivatives
9. Concluding Remarks
References
Chapter 4 The Role of Zinc in DNA and RNA Polymerases
1. Introduction
2. Universal Presence of Zinc in DNA and RNA Polymerases
3. DNA Polymerase
4. RNA Polymerase
5. Possible Role of Intrinsic Zinc
6. Conclusions and Perspective
Abbreviations
References
Chapter 5 The Role of Zinc in Snake Toxins
1. Introduction
2. Metals in Snake Venoms
3. Effect of Chelating Agents
4. Zinc in Purified Hemorrhagic Toxins and Proteolytic Enzymes
References
Chapter 6 Spectroscopic Properties of Metallothionein
1. Introduction
2. Covalent Structure
3. Metal Composition, Removal, and Reconstitution: Preparation of Transition Metal Derivatives
4. Spectroscopic Features of Native and Reconstituted Metallothionein
5. Conformation of the Polypeptide Chain in Metallothionein
6. Coordination Geometry of Metal-Binding Sites in Metallothionein
7. Metal-Thiolate Clusters in Metallothionein
8. Stability of Metal-Protein Complexes in Metallothionein
9. Conclusion
References
Chapter 7 Interaction of Zinc with Erythrocytes
1. Introduction
2. Interaction of Zinc with Erythrocyte Membranes
3. Interaction of Zinc with Hemoglobin
4. Conclusion
Abbreviations
References
Chapter 8 Zinc Absorption and Excretion in Relation to Nutrition
1. Introduction
2. Absorption
3. Excretion
4. Significance for Zinc Nutrition
References
Chapter 9 Nutritional Influence of Zinc on the Activity of Enzymes and Hormones
1. Introduction
2. Effects of Zinc on Metalloenzyme Activity
3. Effects of Zinc on Hormones
References
Chapter 10 Zinc Deficiency Syndrome During Parenteral Nutrition in Humans
1. Introduction
2. Metabolic Aspects of Zinc in Human Nutrition
3. Zinc Deficiency During Parenteral Nutrition
4. Case Reports
References
Author Index
Subject Index
