Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more than 20 human diseases, representing a major public health problem and a scientific challenge. Such a conversion is called protein misfolding. Protein misfolding can also involve errors in the topology of the folded proteins and their assembly in lipid membranes. Lipids are found in nearly all amyloid deposits in vivo, and can critically influence protein misfolding in vitro and in vivo in many different ways. This book focuses on recent advances in our understanding of the role of lipids in modulating the misfolding of various proteins. The main emphasis is on the basic biophysical studies that address molecular basis of protein misfolding and amyloid formation, and the role of lipids in this complex process.
Author(s): Olga Gursky (eds.)
Series: Advances in Experimental Medicine and Biology 855
Edition: 1
Publisher: Springer International Publishing
Year: 2015
Language: English
Pages: 260
Tags: Protein Structure; Biomedicine general; Bioorganic Chemistry
Front Matter....Pages i-xiii
Role of Lipids in Folding, Misfolding and Function of Integral Membrane Proteins....Pages 1-31
Protein Misfolding in Lipid-Mimetic Environments....Pages 33-66
Lipids in Amyloid-β Processing, Aggregation, and Toxicity....Pages 67-94
Role of Cholesterol and Phospholipids in Amylin Misfolding, Aggregation and Etiology of Islet Amyloidosis....Pages 95-116
Intrinsic Stability, Oligomerization, and Amyloidogenicity of HDL-Free Serum Amyloid A....Pages 117-134
Interactions of Lipid Membranes with Fibrillar Protein Aggregates....Pages 135-155
The Role of Lipid in Misfolding and Amyloid Fibril Formation by Apolipoprotein C-II....Pages 157-174
Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights....Pages 175-211
Computational Approaches to Identification of Aggregation Sites and the Mechanism of Amyloid Growth....Pages 213-239
Role of Syndecans in Lipid Metabolism and Human Diseases....Pages 241-258
Back Matter....Pages 259-260
