Contributorsxi
Prefacexxv
Abbreviationsxxvii
Volume One
SECTION 1
Cardiovascular Disease: Past, Present, and Future
1.A History of the Cardiac Diseases, and
the Development of Cardiovascular Medicine
as a Specialty3
Robert A. Harrington, Mark E. Silverman, and Charles F. Wooley
2.The Global Burden of Cardiovascular Diseases19
Catherine P. Benziger, Andrew E. Moran, and Gregory A. Roth
3.Assessing and Improving the Quality of Care
in Cardiovascular Medicine52
Yashashwi Pokharel and John A. Spertus
SECTION 2
Foundations of Cardiovascular Medicine
4.Functional Anatomy of the Heart67
Joseph F. Malouf, Joseph J. Maleszewski, A. Jamil Tajik, and James B. Seward
5.Normal Physiology of the
Cardiovascular System101
Rodrigo Fernandez-Jimenez, Brian D. Hoit, Richard A. Walsh, Valentin Fuster, and Borja Ibanez
6.Molecular and Cellular Biology of the Heart125
Roger J. Hajjar, Kiyotake Ishikawa, and Thomas Thum
7.Biology of the Vessel Wall144
Hillary Johnston-Cox, Valentin Fuster, and Jason C. Kovacic
8.Molecular and Cellular Development
of the Heart161
Miguel Torres and Silvia Martín-Puig
9.Genetic Basis of Cardiovascular Disease174
Eloisa Arbustini, Valentina Favalli, Nupoor Narula, Eliana Disabella, and Maurizia Grasso
v
10.Stem Cells and the Cardiovascular System205
Karim Sallam and Joseph C. Wu
SECTION 3
Evaluation of the Patient
11.The History, Physical Examination, and
Cardiac Auscultation225
William R. Miranda and Rick A. Nishimura
12.Surface Electrocardiography252
Antoni Bayés de Luna, Diego Goldwasser, Miquel Fiol, and Antoni Bayés-Genis
13.Electrocardiographic Exercise Testing318
Gregory S. Thomas and Myrvin H. Ellestad
14.Cardiac Radiography335
Geoffrey D. Rubin
15.Echocardiography353
Thomas H. Marwick, Anthony N. DeMaria, Daniel G. Blanchard, and William A. Zoghbi
16.Magnetic Resonance Imaging of the Heart433
W. Gregory Hundley, Christopher M. Kramer, and Javier Sanz
17.Computed Tomography of the Heart469
Amir Ahmadi, Jagat Narula, and Jonathon Leipsic
18.Nuclear Cardiology499
Daniel S. Berman, Rory Hachamovitch, Leslee J. Shaw, Sean W. Hayes, Piotr J. Slomka, Guido Germano,
and Jagat Narula
19.Positron Emission Tomography
in Heart Disease553
K. Lance Gould, Heinrich Schelbert, and Jagat Narula
20.Cardiac Catheterization, Cardiac Angiography, and Coronary Blood Flow and Pressure
Measurements606
Morton J. Kern and Arnold H. Seto
21.Coronary Intravascular Imaging657
Christos V. Bourantas, Yoshinobu Onuma, Renu Virmani, Jagat Narula, and Patrick W. Serruys
22.Magnetic Resonance Imaging
and Computed Tomography of the
Vascular System686
Marc R. Dweck, Michelle C. Williams, Prakash Krishnan, Valentin Fuster, Jagat Narula, and Zahi A. Fayad
viContents
SECTION 4
Systemic Arterial Hypertension
23.Epidemiology of Hypertension703
Nathan D. Wong and Stanley S. Franklin
24.Pathophysiology of Hypertension720
John E. Hall, Joey P. Granger, Daniel W. Jones, and Michael E. Hall
25.Diagnosis and Treatment of Hypertension751
Lawrence R. Krakoff
SECTION 5
Metabolic Disorders and Cardiovascular Disease
26.The Metabolic Syndrome767
Michael A. Via and Jeffrey I. Mechanick
27.Obesity and Cardiovascular Disease776
W. Timothy Garvey and Jeffrey I. Mechanick
28.Diabetes and Cardiovascular Disease789
Michael E. Farkouh, Elliot J. Rayfield, and Valentin Fuster
29.Hyperlipidemia817
Robert S. Rosenson and Scott M. Grundy
SECTION 6
Cigarette Smoking and Cardiovascular Diseases
30.Epidemiology of Smoking and Pathophysiology
of Cardiovascular Damage849
Sunil K. Agarwal, Petra Maslov, Jagat Narula, and Valentin Fuster
31.Preventing and Mitigating Smoking-Related
Heart Disease860
Sara Kalkhoran and Stanton Glantz
SECTION 7
Atherosclerosis and Coronary Heart Disease
32.Atherothrombosis: Disease Burden, Activity,
and Vulnerability871
Erling Falk and Valentin Fuster
33.Coronary Thrombosis: Local
and Systemic Factors880
Juan Jose Badimon, Borja Ibanez, Valentin Fuster, and Lina Badimon
34.Coronary Blood Flow and Myocardial
Ischemia893
K. Lance Gould, Henry Gewirtz, and Jagat Narula
35.Nonobstructive Atherosclerotic and Nonatherosclerotic Coronary
Heart Disease923
David E. Winchester and Carl J. Pepine
36.Definitions of Acute Coronary Syndromes946
Usman Baber, David Holmes, Jonathan Halperin, and Valentin Fuster
37.Pathology of Myocardial Infarction
and Sudden Death954
Maria E. Romero, Rodrigo Fernandez-Jimenez, Elena Ladich, Valentin Fuster, Borja Ibanez, and Renu Virmani
38.Molecular and Cellular Mechanisms
of Myocardial Ischemia/Reperfusion Injury977
Borja Ibanez, Gerd Heusch, David García-Dorado, Valentin Fuster, and Derek Yellon
39.Evaluation and Management of Non–ST-Segment Elevation
Myocardial Infarction995
David J. Moliterno and James L. Januzzi, Jr.
40.ST-Segment Elevation Myocardial Infarction ... 1017
Manesh R. Patel, Mandeep Singh, Bernard J. Gersh, and William O’Neill
41.Antiplatelet and Anticoagulant Therapy
in Acute Coronary Syndromes1055
Dominick J. Angiolillo, Gregory R. Giugliano, Daniel I. Simon, and Roxana Mehran
42.Percutaneous Coronary Interventions in Acute Myocardial Infarction
and Acute Coronary Syndromes1109
William O’Neill, Cindy Grines, and George Dangas
43.The Evaluation and Management
of Stable Ischemic Heart Disease1132
Bradley A. Maron, Bernard J. Gersh, and Patrick T. O’Gara
44.Coronary Artery Bypass Grafting
and Percutaneous Interventions in Stable
Ischemic Heart Disease1160
Michael E. Farkouh, Samin K. Sharma, Matthew I. Tomey, John Puskas,
and Valentin Fuster
45.Rehabilitation of the Patient with Coronary
Heart Disease1173
Mary Ann McLaughlin
Contentsvii
SECTION 8
Valvular Heart Disease
46.Acute Rheumatic Fever1187
Liesl Zühlke, Jagat Narula, and Jonathan R. Carapetis
47.Aortic Valve Disease1196
Blase A. Carabello and Rebecca T. Hahn
48.Degenerative Mitral Valve Disease1215
Javier G. Castillo, David H. Adams, Blasé A. Carabello, and Partho P. Sengupta
49.Ischemic Mitral Regurgitation1238
John D. Groarke, Blasé A. Carabello, and Patrick T. O’Gara
50.Mitral Stenosis1248
Vinay K. Bahl, Ravi S. Math, and Blasé A. Carabello
51.Tricuspid and Pulmonary Valve Disease1260
Joanna Y. Chikwe and Javier G. Castillo
52.Prosthetic Heart Valves1277
Joanna Chikwe and Javier G. Castillo
53.Antithrombotic Therapy for Valvular
Heart Disease1300
Vinay K. Bahl and Ravi S. Math
54.Management of Mixed Valvular
Heart Disease1310
Blasé A. Carabello
Volume Two
SECTION 9
Congenital Heart Disease
55.Mendelian Basis of Congenital and Other Cardiovascular Diseases1319
Ali J. Marian, Ramon Brugada, and Robert Roberts
56.Congenital Heart Disease in Adolescents
and Adults1363
Jeannette P. Lin, Jamil A. Aboulhosn, and John S. Child
SECTION 10
Myocardial, Pericardial, and Endocardial Diseases
57.Classification of Cardiomyopathies1397
Jagat Narula, Barry J. Maron, Navneet Narula, and Eloisa Arbustini
58.Dilated Cardiomyopathy1408
Eloisa Arbustini, Alessandra Serio, Valentina Favalli,
G.William Dec, and Jagat Narula
59.Hypertrophic Cardiomyopathies1443
Luís R. Lopes and Perry M. Elliott
60.Left Ventricular Noncompaction1465
Eloisa Arbustini, Alessandra Serio, Valentina Favalli, Nupoor Narula, and Maurizia Grasso
61.Restrictive Heart Diseases1482
Eloisa Arbustini, Alessandra Serio, Valentina Favalli,
G.William Dec, Giovanni Palladini, and Jagat Narula
62.Arrhythmogenic Cardiomyopathy1509
Srinivas R. Dukkipati, Peter J. Mohler, Lorenzo Paolo Giuliani, Valentina Favalli, Jagat Narula, and Eloisa Arbustini
63.Myocarditis1528
Eloisa Arbustini, Manuela Agozzino, Valentina Favalli, and Jagat Narula
64.The Athlete and the Cardiovascular
System1561
N. A. Mark Estes III, Mark S. Link, and Barry J. Maron
65.Cardiovascular Disease in the Elderly: Pathophysiology and Clinical
Implications1571
Joshua M. Stolker, Dae H. Kim, and Michael W. Rich
66.Pericardial Diseases1594
William R. Miranda, Massimo Imazio, Kevin L. Greason, John M. Stulak, and Jae K. Oh
67. Infective Endocarditis ....................... 1621
Joseph S. Alpert and Stephen A. Klotz
SECTION 11
Heart Failure
68.Pathophysiology of Heart Failure.............. 1651
Hanna K. Gaggin and G. William Dec
69.The Epidemiology of Heart Failure ............ 1674
Deepak K. Gupta, Charlotte Andersson, Ramachandran S. Vasan, and Thomas J. Wang
70.The Diagnosis and Management of
Chronic Heart Failure ....................... 1690
Tariq Ahmad, Javed Butler, and Barry Borlaug
71.Evaluation and Management of Acute
Heart Failure ............................... 1726
Michelle Weisfelner Bloom, Robert T. Cole, and Javed Butler
viiiContents
72. Cardiac Transplantation ..................... 1746
Michelle M. Kittleson, Jignesh K. Patel, and Jon A. Kobashigawa
73. Mechanically Assisted Circulation. . . . . . . . . . . . . 1768
Joseph G. Rogers, Chetan B. Patel, and Carmelo A. Milano
SECTION 12
Cardiopulmonary Disease
74. Pulmonary Hypertension .................... 1785
Lewis J. Rubin
75. Pulmonary Embolism ....................... 1809
Rodrigo Fernandez-Jimenez, Victor Tapson, Valentin Fuster, and Borja Ibanez
76.Cor Pulmonale: The Heart in Parenchymal
Lung Disease............................... 1835
Ori Ben-Yehuda
77.Sleep-Disordered Breathing and Cardiac
Disease .................................... 1841
Martin R. Cowie
SECTION 13
Rhythm and Conduction Disorders
78.Electrophysiologic Anatomy ................. 1865
Jonathan P. Piccini, Siew Yen Ho, and Anton E. Becker
79.Mechanisms of Cardiac Arrhythmias
and Conduction Disturbances ................ 1881
Peng-Sheng Chen and Charles Antzelevitch
80.Genetics of Channelopathies and Clinical Implications ............................... 1910
Silvia G. Priori and Carlo Napolitano
81.Approach to the Patient with
Cardiac Arrhythmias........................ 1923
Sanjiv M. Narayan and David E. Krummen
82.Invasive Diagnostic Electrophysiology ......... 1938
Dinesh Sharma and Srinivas R. Dukkipati
83.Atrial Fibrillation, Atrial Flutter,
and Atrial Tachycardia....................... 1950
Eric N. Prystowsky, Jonathan Halperin, and Peter Kowey
84.Supraventricular Tachycardia: Atrial Tachycardia, Atrioventricular Nodal Reentry,
and Wolff-Parkinson-White Syndrome ........ 1967
Hugh Calkins
85. Ventricular Arrhythmias..................... 1983
Jason S. Bradfield, Noel G. Boyle, and Kalyanam Shivkumar
86. Bradyarrhythmias .......................... 2006
Pugazhendhi Vijayaraman and Kenneth A. Ellenbogen
87. Antiarrhythmic Drugs....................... 2029
Joshua M. Arkin, Colleen Hanley, Gan-Xin Yan, and Peter R. Kowey
88.Catheter-Ablative Techniques ................ 2047
Amit Noheria, Abhishek J. Deshmukh, Christopher McLeod, and Samuel J. Asirvatham
89.Pacemakers and Defibrillators ................ 2066
Gaurav A. Upadhyay and Jagmeet P. Singh
90.Diagnosis and Management of Syncope ........ 2098
Blair P. Grubb
91. Sudden Cardiac Death....................... 2113
Jonathan W. Waks and Mark E. Josephson
92. Cardiopulmonary and Cardiocerebral
Resuscitation .............................. 2144
Eyal Herzog, Lee Herzog, and Emad Aziz
SECTION 14
Diseases of the Great Vessels and Peripheral Vessels
93. Diseases of the Aorta ........................ 2157
John A. Elefteriades, Jeffrey W. Olin, Jonathan L. Halperin, and Bulat A. Ziganshin
94. Cerebrovascular Disease and Neurologic Manifestations of Heart Disease............... 2195
Megan C. Leary, Jeffrey S. Veluz, and Louis R. Caplan
95. Carotid Artery Stenting...................... 2222
Sriram Iyer, Gary Roubin, and Jeffrey W. Olin
96.Diagnosis and Management of Diseases of the Peripheral Arteries.......................... 2248
Kevin P. Cohoon, Paul W. Wennberg, and Thom W. Rooke
97.Diagnosis and Management of Diseases of the Peripheral Venous System.................... 2261
Daniella Kadian-Dodov and Jeffrey W. Olin
SECTION 15
Miscellaneous Conditions and Cardiovascular Disease
98.Perioperative Evaluation for
Noncardiac Surgery ......................... 2275
Daniel Alyesh and Kim Eagle
Contentsix
99.Anesthesia and the Patient with
Cardiovascular Disease . . . . . . . . . . . . . . . . . . . . . . 2284
David L. Reich, Alexander J. C. Mittnacht, and Joel A. Kaplan
100.Rheumatologic Diseases and the
Cardiovascular System . . . . . . . . . . . . . . . . . . . . . . 2293
Parisa Azizad-Pinto and Victor F. Tapson
101.The Diagnosis and Management of Cardiovascular Diseases in Patients
with Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2308
Gagan Sahni, Tiziano Scarabelli, and Edward T. H. Yeh
102.HIV/AIDS and the Cardiovascular
System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2328
William Lewis and Peter F. Currie
103. Heart Disease in Pregnancy . . . . . . . . . . . . . . . . . . 2345
Dan G. Halpern, Amy Sarma, Katherine E. Economy, and Anne Marie Valente
104. Traumatic Heart Disease . . . . . . . . . . . . . . . . . . . . . 2364
T. Bruce Ferguson, Jr.
105. The Kidney in Heart Disease . . . . . . . . . . . . . . . . . 2369
Bjorn Redfors, Rushad Dordi, and Ori Ben-Yehuda
106.Exercise in Health and Cardiovascular
Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2388
Gerald F. Fletcher, Thomas R. Flipse, and Robert E. Safford
SECTION 16
Populations and Social Determinants of Cardiovascular Disease
107.Social Determinants of Cardiovascular
Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2401
Holly G. Atkinson
108.Women and Ischemic Heart Disease:
An Evolving Saga . . . . . . . . . . . . . . . . . . . . . . . . . . . 2414
Leslee J. Shaw, Pamela Charney, and Nanette K. Wenger
109.Race, Ethnicity, and Cardiovascular Disease . . . . 2434
George A. Mensah and Patrice Desvigne-Nickens
110. Environment and Heart Disease . . . . . . . . . . . . . . 2449
Philip J. Landrigan and Kimberly Morland
111.Behavioral Cardiology: Epidemiology, Pathophysiology, and Clinical Management . . . . 2459
Alan Rozanski
112.Economics and Cost-Effectiveness
in Cardiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2472
Daniel B. Mark
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I1–I78
