Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions

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Genomic and Epigenomic Biomarkers of Toxicology and Disease

The latest developments in biomarker research applicable to toxicology and medicine

Research on genomic and epigenomic biomarkers is developing rapidly with cutting-edge studies scattered throughout the academic literature, making the status of ongoing scientific activity in this area difficult to ascertain.

Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions delivers a comprehensive and authoritative compilation of up-to-date developments in the application of genomic and epigenomic biomarkers to toxicology, disease prevention, cancer detection, therapeutics, gene therapy, and other areas. With contributions from a collection of internationally recognized investigators, this edited volume offers unique insights into current trends and future directions of research in the discussed areas.

Combining state-of-the-art information on genomic and epigenomic biomarkers from a range of specialists from around the world, this monograph includes:

  • A thorough introduction to microRNAs as non-invasive biomarkers of toxicity and chemical hazard
  • Comprehensive explorations of extracellular vesicle-associated miRNAs as toxic biomarkers, as well as transcriptomic applications in toxicology and medicine
  • Practical discussions of circulating miRNAs as biomarkers of metal exposure, as well as microRNAs biomarkers of malignant mesothelioma
  • In-depth examinations of the role of noncoding RNAs in innate immune responses perturbed by environmental arsenic with a focus on microRNAs

Perfect for researchers, toxicologists, risk assessors, and regulators, Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions will also earn a place in the libraries of graduate students with an interest in biomarkers, toxicology, agriculture, or the environment.

Author(s): Saura C. Sahu
Publisher: Wiley
Year: 2022

Language: English
Pages: 504
City: Hoboken

Genomic and Epigenomic Biomarkers of Toxicology and Disease
Contents
Dedication
Preface
Acknowledgements
List of Contributors
1 Genomic and Epigenomic Biomarkers for Predictive Toxicity
and Disease
2 MicroRNAs as Non-invasive Biomarkers of Toxicity and Chemical Hazard:
Genomic and Epigenomic Biomarkers of Toxicology and Disease
3 EV (Extracellular Vesicle)-associated miRNAs as Biomarkers of Toxicity
4 Circulating miRNAs as Biomarkers of Toxic Heavy Metal Exposure
5 MicroRNA Biomarkers of Malignant Mesothelioma
6 Role of Non-coding RNAs in Innate Immune Responses Perturbed by
Environmental Arsenic Exposure
7 Transcriptomics: Applications in Toxicology and Medicine
8 Network Biology for Biomarker Discovery and Therapy in Cancer
9 Epigenetic Biomarkers: Link to Maternal Exposure and Offspring Health
Outcomes
10 The Role of Dynamic Epigenetic Changes in Modulating Homeostasis after
Exposure to Low-dose Environmental Chemicals
11 Emerging Non-invasive Molecular Biomarkers for Early Cancer
Detection
12 Aberrant DNA Methylation of Tumor Suppressor Genes and Oncogenes as
Cancer Biomarkers
13 SMYD Protein Family as Promising Biomarkers for Cancer Diagnosis and
Prognosis
14 Toward Precision Medicine: Epigenetic Alterations in Human
Melanoma
15 Currents Trends and Future Perspectives in Our Epigenetic Signatures:
What a Diet Can Trigger
16 Genetic and Epigenetic Biomarkers of Organophosphate Compounds,
Dialkyl Phosphate Exposure, and Their Relation to Biological Effects
17 Genetic, Epigenetic, and Anatomical Factors in Agenesis and Development
of Female Reproductive Tract
18 Cause or Consequence: Epigenomic DNA Methylation Changes in Arsenic-
Mediated in Vitro Transformation of Human Prostate Cells
19 Epigenetic Regulation of Sex Determination and Toxicity in Nonmammalian
Vertebrates
20 Characterization of Genomic and Epigenomic Biomarkers of Nanoparticle
Toxicity Using the Zebrafish Model System
Index
EULA