Frontiers in Clinical Drug Research: Anti-Cancer Agent

Cover
Title
Copyright
End User License Agreement
Contents
Preface
List of Contributors
Essential Oils and Monoterpenes as Potential Anti-Cancer Agents
Julia Pérez-Ramos1, Nimsi Campos-Xolalpa1, Roberto Serrano1, Cuauhtemoc Pérez1 and Salud Pérez1,*
INTRODUCTION
DISCUSSION
CANCER CELL LINE
ABBREVIATIONS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
A Glance at Drug Delivery Systems and Emerging Immunotherapeutic Strategies for the Treatment of Glioblastoma
Greta Varchi1, Marzia Bruna Gariboldi2 and Claudia Ferroni2,*
INTRODUCTION
GLIOBLASTOMA STANDARD TREATMENT
IMMUNOTHERAPY IN GBM
Immunomodulator Therapy
Passive Immunotherapy: Current State of Immune Checkpoint Inhibitors and Adoptive Therapy
Immune Checkpoint Inhibitors (ICIs)
Adoptive Cell Therapy
Current Vaccine Trials in GBM
Dendritic Cell Vaccine
Peptide Vaccine
Heat Shock Protein-based Vaccine
Combination Strategies
Checkpoint Inhibitors Combination Therapy
Different Combination Strategies Targeting Other Immunotherapeutic Pathways
DRUG DELIVERY-BASED APPROACH
Pre-clinical Studies on Brain-targeted Nanocarriers
Clinical Studies on Brain-targeted Nanocarriers
CONCLUSION AND FUTURE ADVANCES
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
ctDNA in Solid Tumors: Role in Diagnosis, Prognosis and Treatment
Sevgi Akaydin1,*, Ece Miser Salihoğlu1 and Dolunay Merve Fakioğlu1
INTRODUCTION
BREAST CANCER
ctDNA as Diagnostic Biomarker of Breast Cancer
ctDNA as Prognostic Biomarker of Breast Cancer
ctDNA in the Targeted Therapy of Breast Cancer
NON-SMALL CELL LUNG CANCER
ctDNA as Diagnostic Biomarker of Non-Small Cell Lung Cancer
ctDNA as Prognostic Biomarker of Non-Small Cell Lung Cancer
ctDNA in the Targeted Therapy of Non-Small Cell Lung Cancer
COLORECTAL CANCER
Epigenetic Markers as a Diagnostic Biomarker in Colorectal Cancer
ctDNA as a Diagnostic Biomarker in Colorectal Cancer
ctDNA as Prognostic Biomarker in Colorectal Cancer
Predictive ctDNA Markers in Colorectal Cancer
PROSTATE CANCER
ctDNA as Diagnostic Biomarker in Prostate Cancer
ctDNA as Prognostic Biomarker in Prostate Cancer
Predictive ctDNA Markers in Prostate Cancer
OTHER TUMORS
Gastrointestinal Stromal Tumors
Head and Neck Cancer Squamous Cell Carcinoma
Ovarian Cancer
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Pitavastatin and Cancer: Current and Future Prospects
Saeb Aliwaini1,*
INTRODUCTION
PITAVASTATIN: THE CHEMICAL COMPOUND
ANTI-CANCER PROPERTIES OF PITAVASTATIN
Antitumor Effects of Pitavastatin In Vitro
Anti-proliferative Effect of Pitavastatin
Induction of Cell Cycle Arrest
Apoptosis Activation
Activation of Autophagy
Anti-migration Effect
Anti-inflammatory Effect
Antitumor Effects of Pitavastatin In Vivo
Chemical Carcinogenesis Studies
Tumor Xenograft Studies
PITAVASTATIN TARGETS CELLULAR PATHWAYS
LIMITATIONS
CONCLUSION AND FUTURE PERSPECTIVE
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Cholesterol: A Potential Target for Intervention in Anti-Cancer Therapy
Nimai Chand Chandra1,*, Amar Preet Kaur2,#, Ayantika Talukdar3,#, Nimisha Saxena4,# and Shrimanjunath Sankanagoudar5,#
INTRODUCTION
POLYCYCLIC HYDROCARBONS
Potential Carcinogenic Effect
Polycyclic Cholesterol: A Perspective on Cell Proliferation and Carcinogenicity
TRANSMEMBRANE CHOLESTEROL TRANSPORTERS
Plasma Membrane Transporter: LDLR
Mitochondrial Membrane Transporter: StAR and PBR
Nuclear Membrane Transporter: PBR
INTER-CORRELATION BETWEEN CHOLESTEROL TRANSPORTERS AND CELL PROLIFERATION
INTRACELLULAR CHOLESTEROL, CELL CYCLE ACTIVITY AND CELL PROLIFERATION
CHOLESTEROL: A STEER TO CELL CYCLE ACTIVITY AND CELL PROLIFERATION
CHOLESTEROL HOMEOSTASIS IN CANCER TUMOUR CELLS
Cholesterol Homeostasis in Leukemia
Cholesterol Homeostasis in Prostate Carcinoma
Cholesterol Homeostasis in Breast Carcinoma
REPROGRAMMED CHOLESTEROL METABOLISM IN CANCER CELLS
IMMUNE CELL SUPPRESSION BY CARCINOGEN AND CARCINOMA
Does Carcinogen Target Cholesterol to Abrogate Immune Cells?
Effect of Carcinogen on T-Cell Immunity and the Role of Cholesterol
Effect of Carcinogen on B-cell Immunity and the Role of Cholesterol
BIPHASIC ROLE OF CHOLESTEROL IN PROMOTING TUMOR CELL PROLIFERATION AND TUMOR DEFENSIVE IMMUNE CELL DEATH
ANTI-CANCER ANTI-CHOLESTEROL TARGET
ANTI-CANCER DRUG TARGETS: PREVENTION AGAINST INIMICAL DOUBLE-EDGED REPROGRAMMED CHOLESTEROL HOMEOSTASIS
SUMMARY AND CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Subject Index
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