This monograph compiles updated information about forskolin, a labdane diterpene that is produced by the Coleus plant. Forskolin has a large number of practical uses and the book delves into the various aspects of this chemical. It includes topics such as the botanical source of forskolin and the cultivation of Coleus forskohlii, source. It also covers the biosynthetic pathways in natural sources and also through different biotechnological applications. Chapters include the potential and products in the Forskolin market. The book also covers the methods for enhanced production of forskolin from natural sources and through tissue culture methods for improvement of the plant for higher content of forskolin. It discusses the role of endophytes in the production of forskolin.
The book is useful for students and researchers in the field of botany, pharmacology and biochemistry. It also serves scientists in various pharmaceutical industries.
Author(s): T. Pullaiah
Publisher: Springer
Year: 2022
Language: English
Pages: 181
City: Singapore
Preface
Contents
About the Author
1: Coleus forskohlii-A Multipurpose Medicinal Plant
1.1 Introduction
References
2: Botany of Coleus forskohlii
2.1 Introduction
2.2 Botany of Coleus forskohlii
2.3 Chromosome Number
2.4 Genetic Improvement
2.5 Mutation Breeding
References
3: Traditional Medicinal Uses and Pharmacognosy of Coleus forskohlii
3.1 Introduction
3.2 Uses in Traditional Systems of Medicine
3.3 Ethnobotanical Uses
3.3.1 Digestive System
3.3.2 Nervous System
3.3.3 Skin
3.3.4 Respiratory System
3.3.5 Pain, Inflammation, and Musculoskeletal Problems
3.3.6 Metabolic and Endocrine System
3.3.7 Cardiovascular System
3.3.8 Sensory
3.3.9 Infection
3.4 Pharmacognosy
3.4.1 Macroscopic Characters of Root
3.4.2 Microscopic Characters
3.4.3 Study of Powder
3.4.4 Phytochemical Studies
3.4.4.1 Powder Analysis of Whole Plant
3.4.4.2 Physicochemical Analysis of Whole Plant of C. forskohlii (Disticraj and Jayaraman 2015)
3.5 Conclusion
References
4: Chemistry of Coleus forskohlii Briq.
4.1 Introduction
4.2 Biogenesis
4.2.1 Forskolin
4.2.2 Molecular Approach
4.2.2.1 Bioengineering Process for Biosynthesis of Forskolin
4.2.2.2 Genkwanin
4.2.3 Extraction and Separation of Forskolin
4.2.4 Protocol for Separation and Preparation of Pure Forskolin
4.3 Phytocompounds Isolated from C. forskohlii
4.4 Prospective of Bioengineering of Forskolin
4.5 Conclusion
References
5: Pharmacology of Coleus forskohlii and Forskolin
5.1 Introduction
5.2 Pharmacological Properties
5.2.1 Antiobesity
5.2.2 Antidiabetic Effect
5.2.3 Antithrombotic Effect
5.2.4 Cardiovascular Effects
5.2.5 Cystic Fibrosis
5.2.6 Glaucoma
5.2.7 Asthma
5.2.8 Anticancer Activity
5.2.9 Antioxidant Activity
5.2.10 Anti-Inflammatory Activity
5.2.11 Antidepressant Effect
5.2.12 Antistress Effect
5.2.13 Antidyspeptic Activity
5.2.14 Anti-Ulcer Activity
5.2.15 Hepatoprotective Activity
5.2.16 Antimicrobial Activity
5.2.17 Hypothyroidism
5.2.18 Skin Problems
5.2.19 Antispasmodic Effect
5.2.20 Protection against Gastric Ulcers
5.2.21 Bone Formation
5.2.22 Nerve Regeneration
5.2.23 Functional Neural Differentiation of Human Adipose Tissue-Derived Stem Cells
5.2.24 Neuronal Acetylcholinesterase Inhibitor
5.2.25 Antipsoriasis Effect
5.2.26 Anticonvulsant Activity
5.2.27 Neurological Disorders
5.2.28 Immunomodulator Activity
5.2.29 Analgesic Activity
5.2.30 Antiprotozoal Activity
5.2.31 Antimalarial Activity
5.2.32 Anthelmintic Activity
5.2.33 Gastroprotective and Anti-Helicobacter pylori Effects
5.2.34 Other Uses
5.3 Nano-Emulsions and Nanoparticles as Vehicles for Topical Delivery of Forskolin
5.4 Intestinal Permeability of Forskolin
5.5 Effects on Pregnancy
5.6 Toxicological Studies
5.7 Antifeedant Activity
5.8 Patents
References
6: Micropropagation of Coleus forskohlii
6.1 Introduction
6.2 Explant
6.3 Media Constituents for Shoot Induction
6.4 Rooting and Acclimatization
6.5 In Vitro Conservation
6.6 Conclusion and Future Prospects
References
7: In Vitro Production of Forskolin
7.1 Introduction
7.2 Organized Cultures
7.2.1 Hairy Root Cultures
7.2.2 Shoot Cultures
7.3 Unorganized Cultures
7.3.1 Callus Cultures
7.3.1.1 Effect of Sucrose on Callus Induction and Forskolin Content
7.3.1.2 Effect of Plant Growth Regulators on Callus Induction and Growth
7.3.1.3 Growth and Forskolin Profile of Callus Cultures and Suspension Cultures
7.3.2 Suspension Cultures
7.3.2.1 Effect of Biotic Elicitors
7.3.2.2 Elicitation of Forskolin Using Elicitors of Fungal Origin
7.3.2.3 Effect of Bacterial Elicitors
7.3.3 Effect of Microbial Derived Elicitors
7.3.4 Effect of Abiotic Elicitors
7.3.5 Effect of Plant-Derived Elicitors
References
8: Assessment of Coleus forskohlii Genetic Diversity Using Molecular Markers
8.1 Introduction
8.2 Molecular Markers
8.3 Molecular Marker Studies in Coleus forskohlii
8.4 Conclusions
References
9: Endophytes for the Enhanced Growth of Coleus forskohlii and Enhanced Production of Forskolin
9.1 Introduction
9.2 Endophytes and Forskolin Production
References
10: Propagation Methods of Coleus forskohlii
10.1 Introduction
10.2 Propagation
10.3 Intercropping
10.4 Diseases
10.4.1 Leaf Spot Disease
10.4.2 Blight Disease
10.4.3 Root Rot/Wilt Disease
10.4.4 Root Knot Disease of C. forskohlii
10.4.5 Complex Disease of C. forskohlii
10.4.6 Stem Blight
10.5 Disease Management
10.5.1 Chemical Control
10.5.1.1 Fusarial/Bacterial Wilt Control
10.5.2 Biological Control
10.5.2.1 Fusarial/Bacterial Control
10.6 Mulching and Weed Control
10.7 Crop Improvement
References
11: Success Stories and Trade and Commerce of Coleus forskohlii
11.1 Introduction
11.2 Success Story-Dr. Muhammed Majeed
11.2.1 Sami-Sabinsa Corporation
11.3 Trade and Commerce of Coleus Forskohlii
References
