Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology entirely focuses on eosinophils and their functional roles in inflammation, host defense, and normal homeostatic activities. The book explores the ultrastructure of human eosinophils, highlighting biological processes observed under normal, experimental, and pathological conditions.
Created to fill a void in the eosinophil literature, the book includes an extensive array of electron microscopic images that illustrate the diversity of eosinophil morphology. While the atlas is a learning and teaching tool, it is mainly a helpful resource for researchers to identify distinguishing features and structural changes that arise during studies of human eosinophils.
The book also covers the ultrastructure of mouse eosinophils under normal and activation conditions and in the context of representative diseases.
Author(s): Rossana C.N. Melo, Ann M. Dvorak, Peter F. Weller
Publisher: Academic Press
Year: 2022
Language: English
Pages: 518
City: London
Front Cover
Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology
Copyright
Contents
About the authors
Preface
Acknowledgments
Abbreviations
Section A: The cell biology of human eosinophils
Chapter 1 Introduction
Chapter 2 Mature eosinophils: General morphology
2.1 Overview
2.2 Nucleus
2.3 Secretory granules
2.4 Lipid bodies (LBs)
2.5 Eosinophil sombrero vesicles (EoSVs)
2.6 Other organelles and structures
2.6.1 Endoplasmic reticulum (ER)
2.6.2 Golgi complex
2.6.3 Endosomes
2.6.4 Mitochondria
2.6.5 Glycogen particles
Chapter 3 Eosinophils as secretory cells
3.1 Overview
3.2 Classical and compound exocytosis
3.3 Piecemeal degranulation
3.4 Cytolysis
3.5 Extracellular vesicle production
Chapter 4 Eosinophil activation
4.1 Overview
4.2 Ultrastructural changes of secretory granules
4.3 EoSV formation
4.4 Lipid body formation
4.5 Shape changes
4.6 Release of extracellular vesicles (EVs)
Chapter 5 Subcellular localization of immune mediators and other proteins
5.1 Overview
5.2 Major basic protein (MBP)
5.3 Cytokines
5.4 Receptors
5.5 Tetraspanins
5.6 Galectin-10 (Gal-10)
5.7 Enzymes involved in the formation of leukotrienes
Chapter 6 Eosinophil cell death
6.1 Overview
6.2 Cytolytic morphology: General aspects
6.3 Cytolytic morphology: ETosis
6.4 Apoptotic morphology: General aspects
Chapter 7 Immature eosinophils
7.1 Overview
7.2 About immature and mature eosinophil granules
7.3 Maturation stages of human eosinophils characterized by TEM
7.3.1 Early stage of eosinophil development
7.3.2 Middle stage of eosinophil development
7.3.3 Late stage of eosinophil development
Section B: Eosinophils in human diseases
Chapter 8 Eosinophil-associated diseases (EADs)
8.1 Overview
8.2 Allergic airway diseases
8.3 Skin disorders
8.3.1 Atopic dermatitis
8.3.2 Bullous pemphigoid
8.4 Hypereosinophilic syndromes (HESs)
8.5 Eosinophilic granulomatosis with polyangiitis (EGPA)
8.6 Gastrointestinal disorders
8.6.1 Inflammatory bowel disease
8.6.2 Eosinophilic esophagitis
8.7 Infectious diseases
8.7.1 Parasitic infections
8.7.2 Fungal infections
8.7.3 Viral infections
8.7.4 Bacterial infections
8.8 Tumors
8.9 Ultrastructure of CLCs in eosinophilic diseases
Sectiion C: The cell biology of mouse eosinophils
Chapter 9 Ultrastructure of mouse eosinophils
Overview
Mature mouse eosinophils: General morphology
Nucleus
Specific granules
Other organelles and vesicular system
Immature mouse eosinophils
Activation and degranulation of mouse eosinophils
Mice in the context of EADs
Asthma
Schistosomiasis mansoni
References
Figure credits
Index
Back Cover
