‘ENHANZE® drug delivery technology: Advancing subcutaneous drug delivery using recombinant human hyaluronidase PH20’ provides readers with in-depth information on the potential benefits and challenges of subcutaneous (SC) drug delivery, the biology of hyaluronan and hyaluronidases in the SC space, and a comprehensive overview on the history of hyaluronidases and the development of recombinant human hyaluronidase PH20 (rHuPH20). Current applications of rHuPH20 as well as approved biotherapeutics utilizing HuPH20-facilitated SC drug delivery are summarized, and the underlying non-clinical and clinical development approaches are introduced as a basis for future application to biologics in various disease areas.
Author(s): Kang, David W., Tannenbaum, Renee
Publisher: S. Karger Publishing
Year: 2022
Language: English
Pages: 104
City: Oxford
Cover
Enhanze® Drug Delivery Technology
Copyright
Contents
Preface
Acknowledgments
Chapter 1. Introduction to Subcutaneous Drug Delivery
Chapter 2. Biology of Hyaluronan and Hyaluronidases in the Subcutaneous Space
Chapter 3. History of Hyaluronidases and Development of rHuPH20
Chapter 4. The Enhanze® Platform: Clinical Applications of a Subcutaneous Drug Delivery Technology
Chapter 5. Application of Enhanze® Drug Delivery Technology: Development of Currently Marketed Products
Index
Back Cover
