DNA Repair and Cancer: From Bench to Clinic

Content: Overview of DNA repair pathways / Deborah L. Croteau and Vilhelm A. Bohr --
Longevity assurance by genome maintenance / Paul Hasty, Yousin Suh and Jan Vijg --
Genetic instability of cancer : biological predictions and clinical implications / Robert A. Beckman --
Radiation induced DNA damage, repair, and therapeutics / Lynn Harrison --
Chemotherapeutic alkylating agents in cancer treatment / Tracey D. Bradshaw --
O⁶-methylguanine-DNA methyltransferase (MGMT) in cancer protection and therapy / Markus Christmann and Bernd Kaina --
DNA mismatch repair : it's role in human carcinogenesis and as a predictive and/or prognostic biomarker for cancer therapy / Timothy J. Kinsella --
DNA base excision repair therapeutics : summary of targets with a focus on APE1 / Melissa L. Fishel, Carlo Vascotto and Mark R. Kelley --
Nucleotide excision repair : DNA repair capacity variability and cancer susceptibility / Li-E Wang and Qingyi Wei --
Fanconi anemia, interstrand cross-link repair, and cancer / Taraswi Banerjee, Sanjay Kumar Bharti and Robert M. Brosh, Jr --
Functions of translesion DNA polymerases : implications for cancer risk and opportunities as therapeutic targets / Kinrin Yamanaka and R. Stephen Lloyd --
p53 in DNA damage, repair and cancer therapeutics / Aditi Gurkar, Kiki Chu and Sam W. Lee --
ATM/ATR cell cycle checkpoints : mechanisms and manipulation in cancer therapy / Marie Fernet, Sara Chiker and Janet Hall --
The BRCA1-BRCA2 pathway of homologous recombination and the opportunity for synthetic lethal approaches to cancer therapy / Laura J. Eccles ... [et al.] --
PARP and PARP inhibitor therapeutics / Nicola J. Curtin --
Tumor genetics and personalized medicine / Mary Ellen Urick and Daphne W. Bell --
The tumor microenvironment and DNA repair : implications for cancer progression and treatment / Norman Chan, Shaqil Kassam and Robert G. Bristow --
Early phase clinical trials using DNA repair inhibitors : lessons learnt / Miranda Payne and Mark Middleton.