Focusing on all the major cytokine families, this reference book provides coverage of cytokine regulatory processes in the lung and other tissues and comprehensive descriptions of cytokine functions specific to the lung.;Discussing the diverse cytokine-binding proteins and the role of cytokines in tissue injury and repair processes and extracellular matrix regulations, the book supplies information on amino acid structure and gene regulatory sequences, examines the receptor biology of individual cytokines, illustrates cytokine interactions with their cognate receptors and surveys the phenotypic effects of individual cytokines on target cells. With over 2700 literature citations and figures, this book is a resource for pulmonologists, physiologists, immunologists, cell and molecular biologists, environmental toxicologists, oncologists, and graduate-level and medical school students in these disciplines.
Author(s): Jason Kelley
Series: Lung Biology in Health and Disease
Publisher: CRC Press
Year: 1993
Language: English
Pages: 660
City: Boca Raton
Cover
Half Title
Title Page
Copyright Page
Introduction
Preface
Contributors
Table of Contents
Part I: Mitogenic Cytokines
1: Platelet-Derived Growth Factor
I. Introduction
II. Protein Structure
III. Gene Structure, Organization, and Processing
IV. PDGF Receptors
V. Biological Properties of PDGFs
VI. Cellular Sources of PDGF
VII. Regulation of PDGF
VIII. PDGF in Lung Disease
IX. Conclusions
References
2: Fibroblast Growth Factors
I. Introduction
II. History of FGFs
III. Structural Properties
IV. FGF Receptors
V. Interaction with Extracellular Matrix
VI. Biological Properties
VII. The Role of FGFs in Tumor Formation
VIII. FGFs in Lung Biology
References
3: Insulin-Like Growth Factors
I. Introduction
II. IGF Peptides
III. IGF Genes and Transcripts
IV. IGF Receptors
V. IGF-Binding Proteins
VI. Actions of IGFs
VII. Role of IGFs in Fetal Growth
VIII. Role of IGFs in Postnatal Growth
IX. IGFs and Lung
X. Summary
References
4: Transforming Growth Factor-ß
I. Introduction
II. The TGF-ß Family of Proteins
III. Biosynthesis of TGF-ß
IV. Gene Structure of TGF-ßs
V. Control of TGF-ß Gene Expression
VI. Autoinduction of TGF-ß Gene Expression
VII. Activation of TGF-ß Protein
VIII. Receptors for TGF-ß
IX. Signaling Pathways for TGF-ß
X. TGF-ß as a Mitogen
XI. Antiproliferative Effects of TGF-ß
XII. TGF-ß and Extracellular Matrix
XIII. Interactions Between TGF-ß and Other Cytokines
XIV. TGF-ß and the Immune System
XV. TGF-ß in Monocyte-Macrophages, Granulocytes, and Mast Cells
XVI. TGF-ß in Fibroblasts
XVII. Assays for TGF-ß
XVIII. TGF-ß in Lung
XIX. TGF-ß in Remodeling and Fibrosis
XX. Future Directions
References
5: Transforming Growth Factor-a and Epidermal Growth Factor
I. Introduction
II. The Growth Factor Precursor Molecules
III. The Growth Factor Genes
IV. Structure–Function Relationships of the Growth Factors
V. The EGF Receptor
VI. Biological Responses to TGF-a and EGF
VII. The Role of TGF-a and EGF in Lung Development
VIII. The Role of TGF-a and EGF in Pulmonary Neoplasia
IX. The Role of TGF-a and EGF in Lung Repair
X. Conclusion
References
Part II: Proinflammatory Cytokines
6: lnterleukin-1
I. Introduction
II. Historical Perspective
III. Structure
IV. Synthesis
V. IL-l Receptor
VI. Signal Transduction
VII. IL-1 Inhibitors
VIII. IL-1 Effects
IX. Interactions with Other Cytokines
X. IL-1 and the Lung
XI. Summary
References
7: lnterleukin-6 and the Lung
I. Introduction
II. The IL-6 Protein
III. The IL-6 Gene. Structure and Regulation
IV. The IL-6 Receptor
V. Biological Effects of IL-6
VI. IL-6 in Human Homeostasis
VII. IL-6 in the Lung
VIII. Summary
References
8: Interleukin-8
I. Introduction
II. Chemotactic Factors
III. Isolation of IL-8
IV. Structure of IL-8
V. IL-8 Supergene Family
VI. Physicochemical and Biological Effects of IL-8
VII. IL-8 Receptor and Signal Transduction
VIII. Cytokine Networks and the Expression of IL-8
IX. Regulation of IL-8
X. The Potential Role of IL-8 in Pulmonary Disease
References
9: Tumor Necrosis Factor
I. The Tumor Necrosis Factors. Historical Review
II. TNF as a Mediator of Local Inflammation and Septic Shock
III. Pulmonary Sources of TNF Production
IV. Target Cells for TNF within the Lung
V. The Proinflammatory Role of TNF in the Lung In Vivo
VI. Down-Regulation of TNF
VII. Summary and Future Directions
References
10: Enzyme-Releasing Peptide
I. Introduction
II. Neutrophil Granule Enzymes and Their Release
III. The Enzyme-Releasing Peptide
IV. Other Similar Agents
V. Conclusion
References
11: Macrophage Inflammatory Protein-1
I. Introduction
II. Isolation, Cloning, and Preliminary Characterization of MIP-1 Peptides
Ill. Cloning and Characterization of MIP-1a and MIP-1ß cDNAs
IV. Proinflammatory Nature of MIP-1
V. Modulatory Effects of MIP-1 on Hematopoietic Cell Development
VI. Preliminary Receptor Characterization of the MIP-1a and MIP-1ß Receptors
VII. Conclusions
References
Part III: Cytokines in the Lung
12: Myeloid Growth Factors in the Lung
I. Colony-Stimulating Factors
II. Respiratory Cell-Derived CSFs
III. Effects of CSFs on Immature Inflammatory Cells
IV. Effects of CSFs on Mature Inflammatory Cells
V. Implications and Future Directions
References
13: Fibroblast-Pneumonocyte Factor
I. Introduction
II. Epithelial-Mesenchymal Interactions
III. Fibroblast-Pneumonocyte Factor
IV. Conclusion
References
14: Cytokines and Alveolar Type II Cells
I. Introduction
II. Surfactant Synthesis
III. Surfactant Secretion
IV. Surfactant Proteins
V. Type II Cell Proliferation
VI. Production of Cytokines by Alveolar Type II Cells
VII. Other Interactions of Cytokines and Type II Cells
VIII. Conclusions
References
Part IV: Cytokines With Special Effects
15: Cytokine-Binding Proteins
I. Introduction
II. Cytokine-α-Macroglobulin Interactions
III. The Insulin-Like Growth Factor-Binding Proteins
IV. Other Cytokine-Binding Proteins
V. Cytokine-Binding Proteins in Lung Disease
VI. Conclusions
References
16: Cytokine Effects on Extracellular Matrix
I. Introduction
II. Extracellular Matrix in the Normal Lung
Ill. Extracellular Matrix in the Abnormal Lung
IV. Direct Effects of Cytokines on Extracellular Matrix Synthesis
V. Indirect Effects of Cytokines on Extracellular Matrix Production
VI. Summary
VII. Perspectives and Future Directions
References
Author Index
Subject Index
