At first glance, the nervous and immune systems appear very different. However, both systems have developed mechanisms for memory formation – though of quite different quality and significance for the organism. One striking example is that both systems form and communicate via synapses armed with similar sets of proteins. This collection of reviews, contributed by internationally recognized immunologists and molecular and cellular neurobiologists, puts side by side cellular communication devices and signaling mechanisms in the immune and nervous systems and discusses mechanisms of interaction between the two systems, the significance of which has only recently been fully appreciated.
Author(s): Eunjoon Kim, Jaewon Ko (auth.), Eckart D. Gundelfinger, Constanze I. Seidenbecher, Burkhart Schraven (eds.)
Series: Results and Problems in Cell Differentiation 43
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2006
Language: English
Commentary: +OCR
Pages: 313
City: Berlin; New York
Tags: Neurobiology; Cell Biology; Immunology
Molecular Organization and Assembly of the Postsynaptic Density of Excitatory Brain Synapses....Pages 1-23
Molecular Organization and Assembly of the Central Inhibitory Postsynapse....Pages 25-47
Molecular Organization and Assembly of the Presynaptic Active Zone of Neurotransmitter Release....Pages 49-68
Extracellular Matrix and Synaptic Functions....Pages 69-97
Electrical Synapses – Gap Junctions in the Brain....Pages 99-128
Neuron-Glia Interactions at the Node of Ranvier....Pages 129-149
Cognate Interaction Between Endothelial Cells and T Cells....Pages 151-173
Impact of the Immunological Synapse on T Cell Signaling....Pages 175-198
The Biophysics of T Lymphocyte Activation In Vitro and In Vivo....Pages 199-218
Molecular Regulation of Cytoskeletal Rearrangements During T Cell Signalling....Pages 219-244
Membrane-Proximal Signaling Events in Beta-2 Integrin Activation....Pages 245-257
Regulation of Immune Cell Entry into the Central Nervous System....Pages 259-280
Cell–cell communication by Endocannabinoids during Immune Surveillance of the Central Nervous System....Pages 281-305
