"Cadherins are adhesion molecules which mediate homophilic Ca2+-dependent intercellular adhesion. They play a crucial role in tissue morphogenesis during embryonic development and in the maintenance of tissue architecture in adults. In this compilation, the authors review and discuss the structure of the cadherin-mediated junctions in seminiferous tubules and their functions in male fertility. Additionally, role of E-cadh in uterine and mammary gland homeostasis is reviewed, and the disruptive patterns of E-cadh expression in neoplastic conditions of the uterus and mammary glands in humans and domestic dogs and cats are described"--
Author(s): Jonathan McWilliam
Series: Cell Biology Research Progress
Publisher: Nova Science Publishers
Year: 2020
Language: English
Pages: 181
City: New York
Contents
Preface
Chapter 1
Standing Out from the Crowd: Functions of T-Cadherin in Health and Disease
Abstract
Abbreviations
1. Introduction
1.1. Cadherin Superfamily of Intercellular Adhesion Molecules
1.2. Distinguishing T-Cadherin from Other Cadherin Family Members: Structural Features
1.3. Distinguishing T-Cadherin from Other Cadherin Family Members: Signaling Partners and Heterophilic Ligands
2. The Nervous System
2.1. Axon Guidance
2.2. Neuropsychiatric Disorders
3. The Cardiovascular System
3.1. Endothelial Cells and Angiogenesis
3.2. Smooth Muscle Cells and Atherosclerosis
3.3. Vascular Insulin Resistance
3.4. Cardiomyocytes
4. Lung
5. Pancreas
6. Liver
7. Kidney
8. Bone and Cartilage
9. The Cochlea
10. Cancer
10.1. Cutaneous Cancer and Other Proliferative Conditions of the Skin
10.2. Breast Cancer
10.3. Prostate Cancer
10.4. Lung Cancer
10.5. Gastrointestinal Cancers
10.6. Liver Cancer
10.7. Pancreatic Cancer
10.8. Bladder Cancer
10.9. Gallblader Cancer
10.10. Gynaecologic Cancers
10.11. Head and Neck Cancer
10.12. Tumors of the Nervous System
10.13. Blood Cancers
10.14. Osteosarcoma
10.15. Pituitary Gland Tumors
10.16. Retinoblastoma
Conclusion
Acknowledgments
References
Chapter 2
Cadherin-Mediated Cell Adhesion within the Seminiferous Tubules
Abstract
Introduction
Junctional Complexes in the Seminiferous Tubules
Cadherins
Cadherin in the Junctional Complexes of the Seminiferous Tubules
Cadherins Presence in the Seminiferous Tubules
Cadherin Adaptors and Scaffold Proteins
Alternative Adaptors and Scaffolds for N-Cadherin in the Seminiferous Tubules
Junction Dynamics and Spermatogenesis
Conclusion
References
Biographical Sketch
Chapter 3
Disruption of E-Cadherin Pattern in Uterine and Mammary Tumours
Abstract
Introduction
E-Cadherin at the Core of Epithelial Adherens Junctions
E-Cadherin as a Key Modulator during Development and Neoplastic Progression
E-Cadherin Expression in Uterine Cancer
E-Cadherin in the Normal Endometrium
E-Cadherin in Endometrial Carcinomas
E-Cadherin Expression in Mammary Cancer
E-Cadherin Expression in Normal Mammary Tissues
E-Cadherin Expression in Mammary Cancer
Conclusion
References
Index
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