Tracing the life of a giant in inorganic chemistry and key trends in his science, Boranes and Beyond follows Hawthorne from his mid-American origins to the halls of Harvard and UCLA and back again. It naturally details the accomplishments in his lab. This book is a fascinating mixture of science and autobiography. Prof. Hawthorne won the Priestley Medal, the highest award of the American Chemical Society, for his pioneering work in elucidating the chemistry of boron. He has chronicled in this book the developments in his lab which ultimately led to this achievement.
Not content to rest on his laurels, after retiring from UCLA Prof. Hawthorne explored the use of boron in biomedicine and directed the International Institute of Nano & Molecular Medicine at the University of Missouri-Columbia.
Author(s): M. Frederick Hawthorne
Publisher: Springer
Year: 2023
Language: English
Pages: 259
City: New York
Preface
Addendum to the Preface
Contents
Part IMy Contributions to Inorganic Chemistry
1 Exploratory Chemistry with a Multifunctional Model Borane, B10H14
References
2 Discovery of the Polyhedral Borane Anions [closo-B10H10]2− and [closo-B12H12]2−
References
3 The Genesis and Evolution of Carborane Chemistry: Examples of Heteroatom-Substituted Borane Clusters
3.1 Structure–Reactivity Relationships Revealed with the Icosahedral C2B10H12 Isomers
3.2 The Isomeric [Nido-C2B9H12]– Ions
3.3 The Strategic Syntheses of the Medium-Sized closo-Carboranes: C2B6H8 and C2B9H11
3.4 Structure–Reactivity Studies of the closo-C2Bn−2Hn Carboranes (n = 11–9)
References
4 The Design and Synthesis of Hybrid Borane Clusters: Metallacarboranes and Metallaboranes
4.1 Synthesis, Structure and Some Reactions of the Prototype Icosahedral Metallacarboranes
4.2 The Existence of Non-icosahedral Metallacarboranes
4.3 The Design of New Complementary Routes to Metallacarboranes; Polyhedral Expansion, Contraction and Subrogation
References
5 Probing New Reactions: Oxidative Addition to B-H Bonds, Reactions at Metal Vertices and Catalysis
5.1 Oxidative Addition to Terminal B-H Bonds and Deuterium Exchange
5.2 Oxidative Addition to B-H-B Bonds Accompanied by Cluster Formation
5.3 Reactions at Metal Vertices of Metallacarboranes
5.4 Catalyst Precursors and Catalysis with Rhodacarboranes
References
6 The Search for “Clustered Clusters”
References
7 Unique Main Group, Lanthanide and Alkaline-Earth Metallacarboranes; Sandwiches, Baskets, and Self-Assembled Chains
7.1 Aluminum and Silicon Chemistry
7.2 Lanthanacarboranes
7.3 Alkaline-Earth Derivatives
References
8 Biomedical Applications of Borane Cluster Chemistry
8.1 Boron-10 Neutron Capture Therapy (BNCT)
8.2 Bridged Radiometallacarborane Chelates Functionalized for Conjugation and Tumor Imagine or Therapy
8.3 Borane Clusters in Drug Design
References
9 Carborane-Supported Macrocyclic Lewis Acids: Novel Electrophilic Host Species
9.1 Halide Ion Guest Complexes
9.2 Free Host Molecules
9.3 B-Substituted Host Molecules
9.4 Supramolecular Complexes
9.5 Electrophilic Catalysis by Mercuracarborands
References
10 Molecular Frameworks Based upon Carborane Cages
10.1 Rigid Molecular Rods (“Carborods”)
10.2 Novel Macrocycles (“Carboracycles”)
References
11 Highly Alkylated Carborane Icosahedral [closo-B12H12]2− Derivatives (“Camouflaged Carboranes and Polyhedral Boranes”)
11.1 Alkylation of Icosahedral Carboranes and Related Reactions
11.2 The Synthesis of [closo-B12(CH3)12]2− the First Camouflaged Polyhedral Borane Dianion
11.3 Organic Reactions of the Carborane Hydrocarbon Sheath
References
12 Icosahedral Borane Dianion and Carborane Species with Hydroxylated Surfaces
Reference
13 Advances in [closo-B10H10]2− and Related [B20H18]2−/[B20H18]4− Chemistry
13.1 The Chemistry of [B20H18]2− Species
13.2 Carbon−Hydrogen Bond Activation by [B10H10]2− in Strong Acid: Evidence for a [B10H13]+ Electrophile
References
From the Photo Album
Part IIMy Personal Story
14 Early Life in Kansas and Missouri
15 WWII, High School and Chemistry
16 College Entry and Chemistry Mentor
17 Pomona College and Chemistry Research
18 UCLA Graduate Work with Donald J. Cram & Predoctoral Fellowship
References
19 Ph.D. Thesis
20 Postdoctoral Research with George Hammond at Iowa State
21 Huntsville Research at Start of My Career
22 Life with Explosives & Rockets
23 Creating a New Research Group Based Upon Sparsely Known Borane Chemistry
24 Success in New Fields of Propellant Chemistry
25 Moving on to New Concepts for Solid Propellant Rocket Fuel
26 Energetic Materials
27 Ralph Connor and Rohm and Haas Huntsville
28 Harvard Teaching
29 Laboratory Head at Rohm and Haas in Philadelphia
30 Full Professor at UC Riverside and Flying
31 Metallacarboranes Etc.
32 Flying with Herb Brown
33 Hank Herring
34 Industrial and Military Consulting
35 BNCT
36 UCLA Professor 1969–2006
37 Editorship of Inorganic Chemistry
38 Return to Missouri; the Founding Director of the International Institute of Nano and Molecular Medicine
References
39 Personal Experience with Head and Neck Cancer
40 BNCT Odyssey
Reference
After-Words
Awards, Honors and Lectureships
Bibliography
