Biologically Active Small Molecules: Modern Applications and Therapeutic Perspectives

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Biologically Active Small Molecules: Modern Applications and Therapeutic Perspectives focuses on small molecules as active pharmacological agents, their pharmacotherapeutically active properties, new approaches in drug discovery using small molecules, and biopharmaceutic approaches for low molecular weight ligands.

Molecules of low mass play a pivotal role in pharmacology because they exhibit multifarious pharmacological effects. Small molecules have become universally popular due to their simple chemistry, easy separation techniques, versatile acceptance for computational studies, large number of places for the substitution of active chemical moieties by well-established synthetic routes with less effort, better quality attributes, and ability to demonstrate numerous biological activities.

This book provides a multidisciplinary approach that delivers the most updated knowledge and advances of some newly developed therapeutically active low molecular weight compounds. It includes chapters that present up-to-date and concise content on the classification, structures, chemical syntheses, medicinal chemistry, pharmacology, biochemical pathways, mechanism of actions, side effects, and adverse effects of small molecule drug discovery. The book covers a broad area by highlighting the advances of inter- and multidisciplinary fields of medicine, chemical sciences, and pharmaceuticals. The flowcharts, figures, illustrations, and diagrams provide important information and will be of great interest for readers.

Author(s): Debarshi Kar Mahapatra, Sanjay Kumar Bharti
Publisher: CRC Press/Apple Academic Press
Year: 2023

Language: English
Pages: 389
City: Palm Bay

Cover
Half Title
Title Page
Copyright Page
About the Editors
Table of Contents
Contributors
Abbreviations
Foreword
Preface
Part I: Small Molecules as Active Pharmacological Agents
Chapter 1: Bedaquiline: The New Antituberculosis Drug on the Horizon
Chapter 2: Plant-Derived Natural Products as Antiglycating Agents
Chapter 3: Perspectives of Chalcone-Based Nf-Κβ Inhibitors as Anti-Inflammatory Agents
Chapter 4: Coronaviruses: Molecular Modeling and Docking Studies of Potential Drug Candidates Showing Anti-Covid-19 Activity
Part II: Pharmacotherapeutically Active Classes
Chapter 5: Perspectives on Local Anesthetics in Medicine
Chapter 6: Pharmacotherapeutic Perspectives on Adrenergic Agonists
Chapter 7: Therapeutic Perspectives of Adrenergic Antagonists
Chapter 8: Skeletal Muscle Relaxants: Concepts and Developments
Chapter 9: Nonsteroidal Anti-Inflammatory Drugs: Concepts and Innovations
Part III: Modern Approaches in Small Molecule Drug Discovery
Chapter 10: Biological Databases: Tool for Low Molecular Weight Ligand Discovery Process
Chapter 11: High-Throughput Screening Technique: Role in the Drug Discovery of Low Molecular Weight Ligands
Chapter 12: Homology Modeling: Applications in the Low Molecular Weight Ligand Designing
Part IV: Biopharmaceutics Approaches for Low Molecular Weight Ligands
Chapter 13: Drug Metabolism: Detoxification and Xenobiotic Biotransformation
Chapter 14: Drug Interactions: Highlights of Adverse Effects of Low Molecular Weight Ligands
Part V: Evaluation Methods for Small Molecules
Chapter 15: Low Molecular Weight Antioxidant Agents and Model for Their Evaluation
Index