This concise but comprehensive textbook sets out the essentials of the science and clinical application of radibiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer. New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect. A variety of new authors have contributed to this revision, who, together with the new Editorial team, have used their significant international teaching experience to ensure the content remains clear and comprehensive, and as valuable to the trainee as it is to the established radiation oncologist.
Author(s): Albert Van der Kogel, Michael Joiner
Edition: 4th
Year: 2009
Language: English
Pages: 375
Book title......Page 2
Contents......Page 4
Colour plates......Page 226
List of contributors......Page 6
Preface......Page 8
1 Introduction: the significance of radiobiology and radiotherapy for cancer treatment......Page 10
2 Irradiation-induced damage and the DNA damage response......Page 20
3 Cell death after irradiation: how, when and why cells die......Page 36
4 Quantifying cell kill and cell survival......Page 50
5 Dose–response relationships in radiotherapy......Page 65
6 Linear energy transfer and relative biological effectiveness......Page 77
7 Tumour growth and response to radiation......Page 87
8 Fractionation: the linear-quadratic approach......Page 111
9 The linear-quadratic approach in clinical practice......Page 129
10 Modified fractionation......Page 144
11 Time factors in normal-tissue responses to irradiation......Page 158
12 The dose-rate effect......Page 167
13 Pathogenesis of normal-tissue side-effects......Page 178
14 The volume effect in radiotherapy......Page 200
15 The oxygen effect and fractionated radiotherapy......Page 216
16 The tumour microenvironment and cellular hypoxia responses......Page 233
17 Therapeutic approaches to tumour hypoxia......Page 249
18 Combined radiotherapy and chemotherapy......Page 262
19 Retreatment tolerance of normal tissues......Page 275
20 Molecular image-guided radiotherapy with positron emission tomography......Page 287
21 Molecular-targeted agents for enhancing tumour response......Page 303
22 Biological response modifiers: normal tissues......Page 317
23 Molecular targeting and patient individualization......Page 332
24 Protons and other ions in radiotherapy......Page 348
25 Second cancers after radiotherapy......Page 355
B......Page 369
D......Page 370
G......Page 371
L......Page 372
P......Page 373
S......Page 374
X......Page 375
B......Page 377
C......Page 378
D......Page 380
F......Page 381
G......Page 382
I......Page 383
L......Page 384
N......Page 385
P......Page 386
R......Page 387
S......Page 388
T......Page 389
V......Page 390
Z......Page 391
